Multidisciplinary Collaborative Clinical Research, Core Facilities and Other Clinical Services in NIDDK Program Area Diseases

NIDDK 项目领域疾病的多学科合作临床研究、核心设施和其他临床服务

基本信息

批准号：
9356270
负责人：
James Balow
金额：
$ 56.98万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9356270
关键词：
Antineutrophil Cytoplasmic Antibodies Area Biometry Biopsy Blood Glucose Chronic Granulomatous Disease Clinical Clinical Investigator Clinical Research Clinical Research Protocols Clinical Services Collection Consultations Core Facility Cystic Fibrosis Cystinosis Databases Development Diabetes Mellitus Diagnosis Disease Endocrine Endocrinology Endoscopy Endothelial Cells Erdheim-Chester Disease Functional disorder Gastroenterology Gastrointestinal Endoscopy HIV Hematology Hemodialysis Hemofiltration Hepatology Hermanski-Pudlak Syndrome Human Immunotherapy Institutes Institutional Review Boards Insulin Insulin Resistance Intramural Research Program Kidney Laboratory Research Lead Liver Medical Membranous Glomerulonephritis Metastatic Melanoma Mission Monitor National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Allergy and Infectious Disease National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Diabetes and Digestive and Kidney Diseases Natural History Nephrology Obesity Pathogenesis Patient Care Patients Pharmacotherapy Process Protocols documentation Renal function Renal glomerular disease Research Research Project Grants Sampling Services Sickle Cell Anemia Stem cell transplant Testing Therapeutic procedure United States National Institutes of Health Vasculitis Venous Von Hippel-Lindau Syndrome antitumor agent biobank capsule cell injury chemotherapy clinical investigation disease natural history gastrointestinal graft vs host disease human subject indexing liver biopsy medical specialties member methylmalonic aciduria multidisciplinary novel novel strategies programs protocol development

Antineutrophil Cytoplasmic Antibodies Area Biometry Biopsy Blood Glucose Chronic Granulomatous Disease Clinical Clinical Investigator Clinical Research Clinical Research Protocols Clinical Services Collection Consultations Core Facility Cystic Fibrosis Cystinosis Databases Development Diabetes Mellitus Diagnosis Disease Endocrine Endocrinology Endoscopy Endothelial Cells Erdheim-Chester Disease Functional disorder Gastroenterology Gastrointestinal Endoscopy HIV Hematology Hemodialysis Hemofiltration Hepatology Hermanski-Pudlak Syndrome Human Immunotherapy Institutes Institutional Review Boards Insulin Insulin Resistance Intramural Research Program Kidney Laboratory Research Lead Liver Medical Membranous Glomerulonephritis Metastatic Melanoma Mission Monitor National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Allergy and Infectious Disease National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Diabetes and Digestive and Kidney Diseases Natural History Nephrology Obesity Pathogenesis Patient Care Patients Pharmacotherapy Process Protocols documentation Renal function Renal glomerular disease Research Research Project Grants Sampling Services Sickle Cell Anemia Stem cell transplant Testing Therapeutic procedure United States National Institutes of Health Vasculitis Venous Von Hippel-Lindau Syndrome antitumor agent biobank capsule cell injury chemotherapy clinical investigation disease natural history gastrointestinal graft vs host disease human subject indexing liver biopsy medical specialties member methylmalonic aciduria multidisciplinary novel novel strategies programs protocol development

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项目摘要

Credentialed NIDDK clinical staff members have relevant expertise necessary to support patient care needs of human subjects involved in clinical research conducted by all institutes and centers in the intramural research program. Consultative interactions provided by NIDDK clinicians with expertise in the fields of diabetes, endocrinology, metabolism, gastroenterology, hepatology, nephrology and hematology are required for delivery of specialized medical services to patients throughout the Clinical Research Center at NIH. Beyond patient support services, these consultative interactions lead to collaborative clinical investigations to advance the study of natural history of disease, new approaches to diagnosis and treatment, as well as advancing the understanding of disease pathogenesis and pathophysiology. Clinical services include: 1. Blood Glucose Management Service involves comprehensive management of patients with insulin deficient or insulin resistant diabetes mellitus. 2. Consultation services in endocrinology, gastroenterology, hepatology, nephrology, cystic fibrosis and hematology. 3. Gastrointestinal endoscopy, including capsule endoscopy, gut biopsies and therapeutic procedures 4. Liver biopsies and liver fibroscanning 5. Renal biopsies, hemodialysis, continuous veno-venous hemofiltration, specialized research renal function tests 6. Biorepository: collection, barcoding, indexing, storing, and retrieving human samples 7. Biostatistical support for developing, monitoring, analyzing clinical research protocols Examples of completed and ongoing collaborative clinical research projects emerging from consultation services and clinical core services include: 1. Endocrine, gastrointestinal, liver and kidney complications of immunotherapy of metastatic melanoma, stem cell transplantation, chemotherapy and novel biologic anti-tumor agents (NCI, NHLBI, NIAID); 2. Gastrointestinal and renal complications of graft versus host disease (NHLBI, NCI, NIAID); 3. Liver and kidney complications of chronic granulomatous disease (NIAID), Hermansky-Pudlak syndrome, methylmalonic acidemia, Erdheim-Chester disease and cystinosis(NHGRI); 4. Natural history and management of kidney and liver complications of sickle cell anemia (NHLBI); 5. Renal complications of HIV disease and HIV drug therapies (NCI, NIAID); 6. Kidney complications of von Hippel-Lindau disease (NCI); 7. Membranous nephropathy in patients with non-myeloablative stem cell transplants (NHLBI, NCI); 8. Glomerular disease in ANCA-associated vasculitis (NIAMS); 9. Glomerular endothelial cell injury and thrombotic microangiopathy in stem cell transplants (NHLBI, NCI, NIAID, NIDDK)

凭证的NIDDK临床工作人员具有相关的专业知识，以支持所有研究所和中心在壁内研究计划中进行的临床研究的患者护理需求。 NIDDK临床医生提供的咨询相互作用在糖尿病，内分泌学，代谢，胃肠病学，肝病学，肾脏病和血液学领域具有专业知识是为了向NIH临床研究中心的整个临床研究中心提供专业医疗服务所必需的。除了患者支持服务之外，这些咨询相互作用还会进行协作临床研究，以推动对疾病自然史的研究，诊断和治疗的新方法以及对疾病发病机理和病理生理学的理解。临床服务包括： 1。血糖管理服务涉及胰岛素缺乏或胰岛素抗性糖尿病患者的全面管理。 2。内分泌学，胃肠病学，肝病学，肾脏病，囊性纤维化和血液学的咨询服务。 3。胃肠道内窥镜检查，包括胶囊内窥镜检查，肠活检和治疗方法 4。肝活检和肝纤维固定 5。肾脏活检，血液透析，连续静脉血液滤过，专业研究肾功能测试 6。生物座席：收集，条形码，索引，存储和检索人类样品 7。生物统计支持，用于开发，监测，分析临床研究方案咨询服务和临床核心服务中出现的完整和正在进行的合作临床研究项目的示例包括： 1。内分泌，胃肠道，肝脏和肾脏并发症的转移性黑色素瘤，干细胞移植，化学疗法和新型生物学抗肿瘤剂（NCI，NCI，NHLBI，NIAID）的免疫疗法； 2。移植物与宿主疾病的胃肠道和肾脏并发症（NHLBI，NCI，NIAID）； 3。慢性肉芽肿性疾病（NIAID），Hermansky-Pudlak综合征，甲基乳酸酸血症，Erdheim-Chester疾病和囊肿性疾病（NHGRI）的肝脏和肾脏并发症（NHGRI）； 4。镰状细胞贫血（NHLBI）的肾脏和肝脏并发症的自然史和管理； 5。HIV疾病和HIV药物疗法的肾脏并发症（NCI，NIAID）； 6。von Hippel-Lindau病（NCI）的肾脏并发症； 7。非毛囊干细胞移植患者（NHLBI，NCI）患者的膜性肾病； 8。与ANCA相关血管炎（NIAMS）中的肾小球疾病； 9。干细胞移植中的肾小球内皮细胞损伤和血栓形成微型病变（NHLBI，NCI，NIAID，NIDDK）