Impacts of Human Movement on Regional Strain Distribution of Diarrheagenic E.coli

人体运动对腹泻性大肠杆菌区域菌株分布的影响

• 批准号: 9066073
• 负责人: Karen Levy
• 金额: $ 13.1万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9066073
• 关键词: Address; Affect; Area; Biological; Blood Circulation; Case-Control Studies; Cessation of life; Childhood; Clinic; Collaborations; Collection; Communicable Diseases; Country; Data; Diarrhea; Diarrheagenic E. coli; Disease; Ecology; Ecuador; Ecuadorian; Enrollment; Enteral; Environmental Health; Epidemiologic Studies; Epidemiology; Escherichia coli; Genetic; Genetic screening method; Genomics; Genotype; Geographic Locations; Goals; Health; Hospitals; Human; Infection; Infectious Disease Epidemiology; International; K-Series Research Career Programs; Knowledge; Learning; Libraries; Location; Manuscripts; Mentors; Michigan; Modeling; Molecular; Molecular Epidemiology; Movement; Pattern; Phylogenetic Analysis; Play; Population; Price; Principal Investigator; Process; Province; Public Health Schools; Publications; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Risk Factors; Role; Running; Rural; Series; Signal Transduction; Site; System; Techniques; Time; Training; Training Activity; Training Programs; Travel; Universities; Urban Population; Washington; Water; bacterial genetics; base; career; career development; case control; design; disease transmission; experience; genome sequencing; insight; lens; microbial; pathogen; pathogenic Escherichia coli; professor; rural area; senior faculty; skills; social; transmission process; urban area; whole genome

DESCRIPTION (provided by applicant): This proposal describes a career development and training plan for Dr. Karen Levy, Assistant Professor in the Department of Environmental Health at Emory University's Rollins School of Public Health. Dr. Levy's career goal is to become an independent investigator in the epidemiology and ecology of infectious diseases with a focus on enteric diseases. The K01 mentored career development award will allow her to build on ongoing collaborations, develop relationships with new mentors, and have protected time to produce scientific manuscripts that will bolster her already strong publication record. Dr. Levy will receive training in molecular epidemiology and bacterial genetics by (1) participating in a series of short courses; (2) gaining experience and training in microbial genomics; and (3) receiving mentoring from an exceptional team of senior faculty. Through this training program, Dr. Levy will increase her capacity to integrate social, epidemiological, and molecular data towards understanding mechanisms of infectious disease transmission and spread. Her mentoring team includes experts in infectious disease epidemiology: Drs. Uriel Kitron and Les Real at Emory University and Dr. Betsy Foxman at University of Michigan. ENVIRONMENT: Emory University provides an excellent venue for Dr. Levy to develop a career as an independent investigator and the university has signaled its commitment to Dr. Levy's career development. Emory's strengths in water and health studies and disease ecology make it especially suited to incubation of a career in the epidemiology of enteric diseases. RESEARCH: The proposed research project will use fine-scale genetic data to understand transmission processes at multiple spatial scales, from local to country-wide, affecting the distribution of diarrheagenic E. coli strains in the Borbon region of the Ecuadorian province of Esmeraldas. The goal of the research is to investigate the role that human travel between urban and rural regions plays in determining the distribution of circulating strains of pathogenic E. coli. This is important because the strains in circulation affect the occurrence of diarrheal illness in na¿ve populations. The research approach combines a classic epidemiological case-control study design with whole genome sequencing, phylogenetic analysis, and data on human movement to address the following Specific Aims: (1) Investigate travel as a risk factor for enteric diseases, specifically diarrheagenic E. coli; (2) Examine the role of a regional population center as a common hub of diarrheagenic E. coli strains circulating in outlying rural villages; (3) Investigate parallels between genetic similarity of pathogenic E. coli strains and human movement patterns on a country-wide scale. This research will widen the lens by which to view and design optimal control strategies for the control of enteric diseases. The results will provide insights into whether investing in infrastructure to control pathogens in dense population centers could also affect conditions in outlying rural areas by limiting regional circulation of diverse strains of diarrheagenic E. coli.

描述（由应用程序提供）：该提案描述了埃默里大学Rollins公共卫生学院环境卫生系助理教授Karen Levy博士的职业发展和培训计划。 Levy博士的职业目标是成为传染病流行病学和生态学的独立研究者，重点是进入疾病。 K01修订的职业发展奖将使她能够建立持续的合作，与新导师建立关系，并保护时间来制作科学手稿，从而增强她本来已经有很强的出版记录。 Levy博士将通过（1）参加一系列短期课程接受分子流行病学和细菌遗传学的培训； （2）获得微生物基因组学的经验和培训； （3）从一支高级教师团队中接受心理。通过此培训计划，Levy博士将提高她将社会，流行病学和分子数据整合到了解传染病传播和传播机制方面的能力。她的心理团队包括传染病流行病学专家：博士。埃默里大学（Emory University）的Uriel Kitron和Les Real和密歇根大学的Betsy Foxman博士。环境：埃默里大学（Emory University）为利维（Levy）博士提供了一个绝佳的场所，以发展独立调查员的职业，该大学已签署了对Levy博士的职业发展的承诺。埃默里（Emory）在水，健康研究和疾病生态学方面的优势使其特别适合孵化肠道疾病流行病学的职业。研究：拟议的研究项目将使用精细的遗传数据来了解从本地到全国各个空间尺度的传输过程，从而影响厄瓜多尔省Esmeraldas北极地区的腹泻大肠杆菌菌株的分布。该研究的目的是研究人类在城市和农村地区之间行进在确定致病大肠杆菌循环菌株分布中所发挥的作用。这是 重要的是因为循环中的菌株会影响NA的人群中腹泻病的发生。该研究方法将经典的流行病学病例对照研究设计与整个基因组测序，系统发育分析和人类运动的数据结合在一起，以解决以下特定目的：（1）将旅行作为肠性疾病的风险因素，特别是腹泻性大肠杆菌的风险因素； （2）研究区域人口中心作为在偏远农村村庄中循环的腹泻大肠杆菌菌株的常见枢纽； （3）调查 在全国范围内，致病性大肠杆菌菌株的遗传相似性与人类运动模式之间的相似之处。这项研究将扩大查看和设计控制肠道疾病的最佳控制策略的镜头。结果将提供有关在密集人群中控制病原体的基础设施投资是否也会通过限制腹泻大肠杆菌的潜水员菌株的区域循环来影响状况的洞察力。