Impacts of Human Movement on Regional Strain Distribution of Diarrheagenic E.coli

人体运动对腹泻性大肠杆菌区域菌株分布的影响

• 批准号: 8581366
• 负责人: Karen Levy
• 金额: $ 13.1万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8581366
• 关键词: Address; Affect; Area; Biological; Blood Circulation; Case-Control Studies; Cessation of life; Childhood; Clinic; Collaborations; Collection; Communicable Diseases; Country; Data; Diarrhea; Disease; Ecology; Ecuador; Enrollment; Enteral; Environmental Health; Epidemiologic Studies; Epidemiology; Escherichia coli; Faculty; Genetic; Genetic screening method; Genomics; Genotype; Geographic Locations; Goals; Health; Hospitals; Human; Infection; Infectious Disease Epidemiology; International; K-Series Research Career Programs; Knowledge; Learning; Libraries; Location; Manuscripts; Mentors; Michigan; Modeling; Molecular; Molecular Epidemiology; Movement; Pattern; Phylogenetic Analysis; Play; Population; Price; Principal Investigator; Process; Province; Public Health Schools; Publications; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Risk Factors; Role; Running; Rural; Series; Signal Transduction; Site; System; Techniques; Time; Training; Training Activity; Training Programs; Travel; Universities; Urban Population; Washington; Water; bacterial genetics; base; career; career development; case control; design; disease transmission; experience; genome sequencing; insight; lens; microbial; pathogen; pathogenic Escherichia coli; professor; rural area; skills; social; transmission process; urban area

DESCRIPTION (provided by applicant): This proposal describes a career development and training plan for Dr. Karen Levy, Assistant Professor in the Department of Environmental Health at Emory University's Rollins School of Public Health. Dr. Levy's career goal is to become an independent investigator in the epidemiology and ecology of infectious diseases with a focus on enteric diseases. The K01 mentored career development award will allow her to build on ongoing collaborations, develop relationships with new mentors, and have protected time to produce scientific manuscripts that will bolster her already strong publication record. Dr. Levy will receive training in molecular epidemiology and bacterial genetics by (1) participating in a series of short courses; (2) gaining experience and training in microbial genomics; and (3) receiving mentoring from an exceptional team of senior faculty. Through this training program, Dr. Levy will increase her capacity to integrate social, epidemiological, and molecular data towards understanding mechanisms of infectious disease transmission and spread. Her mentoring team includes experts in infectious disease epidemiology: Drs. Uriel Kitron and Les Real at Emory University and Dr. Betsy Foxman at University of Michigan. ENVIRONMENT: Emory University provides an excellent venue for Dr. Levy to develop a career as an independent investigator and the university has signaled its commitment to Dr. Levy's career development. Emory's strengths in water and health studies and disease ecology make it especially suited to incubation of a career in the epidemiology of enteric diseases. RESEARCH: The proposed research project will use fine-scale genetic data to understand transmission processes at multiple spatial scales, from local to country-wide, affecting the distribution of diarrheagenic E. coli strains in the Borbon region of the Ecuadorian province of Esmeraldas. The goal of the research is to investigate the role that human travel between urban and rural regions plays in determining the distribution of circulating strains of pathogenic E. coli. This is important because the strains in circulation affect the occurrence of diarrheal illness in na¿ve populations. The research approach combines a classic epidemiological case-control study design with whole genome sequencing, phylogenetic analysis, and data on human movement to address the following Specific Aims: (1) Investigate travel as a risk factor for enteric diseases, specifically diarrheagenic E. coli; (2) Examine the role of a regional population center as a common hub of diarrheagenic E. coli strains circulating in outlying rural villages; (3) Investigate parallels between genetic similarity of pathogenic E. coli strains and human movement patterns on a country-wide scale. This research will widen the lens by which to view and design optimal control strategies for the control of enteric diseases. The results will provide insights into whether investing in infrastructure to control pathogens in dense population centers could also affect conditions in outlying rural areas by limiting regional circulation of diverse strains of diarrheagenic E. coli.

描述（由申请人提供）：本提案描述了埃默里大学罗林斯公共卫生学院环境健康系助理教授 Karen Levy 博士的职业发展和培训计划。 Levy 博士的职业目标是成为一名独立调查员。 K01 指导的职业发展奖将使她能够在传染病的流行病学和生态学方面取得进展，并与新导师建立关系，并有足够的时间来进行科学研究。 Levy 博士将通过以下方式接受分子流行病学和细菌遗传学方面的培训：(1) 参加一系列短期课程；(2) 获得微生物基因组学方面的经验和培训；通过这个培训项目，利维博士将提高她整合社会、流行病学和分子数据以了解传染病传播和传播机制的能力。她的指导团队包括传染病流行病学专家：埃默里大学的 Uriel Kitron 博士和 Les Real 博士以及密歇根大学的 Betsy Foxman 博士 环境：埃默里大学为 Levy 博士发展作为独立研究者的职业生涯提供了绝佳的场所，并且该大学已表明了对 Levy 博士的承诺。埃默里大学在水和健康研究以及疾病生态学方面的优势使其特别适合孵化肠道疾病流行病学研究领域的职业发展。使用精细的遗传数据来了解从地方到全国范围内多个空间尺度的传播过程，影响厄瓜多尔埃斯梅拉达斯省博尔本地区的致腹泻大肠杆菌菌株的分布。该研究的目标是调查。人类在城市和农村之间的旅行在确定致病性大肠杆菌的传播菌株分布方面所起的作用。 很重要，因为循环中的菌株会影响腹泻疾病的发生。该研究方法将经典的流行病学病例对照研究设计与全基因组测序、系统发育分析和人类活动数据相结合，以实现以下具体目标：（1）调查旅行作为肠道疾病（特别是腹泻性疾病）的危险因素。大肠杆菌； (2) 检查区域人口中心作为边远乡村流行的腹泻大肠杆菌菌株的作用； (3) 调查 这项研究将拓宽观察和设计控制肠道疾病的最佳控制策略的视角。投资基础设施来控制人口稠密中心的病原体也可能通过限制不同致泻性大肠杆菌菌株的区域传播来影响边远农村地区的情况。