Expansion and modification of animal housing and support spaces to increase production of the NIH U42 supported pigtailed macaque colony at Johns Hopkins University

扩大和改造动物饲养和支持空间，以增加约翰·霍普金斯大学 NIH U42 支持的猪尾猕猴群的产量

• 批准号: 10592753
• 负责人: Eric Kenneth Hutchinson
• 金额: $ 550.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592753
• 关键词: AIDS/HIV problem; Animal Housing; Animal Model; Animals; Area; Behavioral; Biomedical Research; Breeding; COVID-19; Communities; Farm; Fiber Optics; Funding; Health behavior; Human Resources; Institution; Internet; Macaca nemestrina; Modeling; Modification; Network Infrastructure; Operating Rooms; Primates; Production; Productivity; Radiology Specialty; Records; Research; Research Personnel; Resources; Sales; Security; Speed; United States National Institutes of Health; Universities; design; improved; innovation; nonhuman primate; novel

Project Summary In the face of well-documented ongoing shortages of nonhuman primates for biomedical research and evidence that they may be a unique model for COVID-19, it is no surprise that the demand for pigtail macaques remains strong and continues to climb. Since the onset of NIH- support in 2006, the JHU pigtail macaque colony has provided 313 animals for biomedical research, the vast majority of which was HIV/AIDS related. With 172 of those animals (55%) going to NIH funded investigators at institutions outside of JHU, we have established our colony as an important national resource of this valuable animal model. To meet the growing need for pigtail macaques in biomedical research, we have developed a plan to significantly increase the number of animals that we can house at the JHU Research Farm and further refine our behavioral management of this breeding colony to improve productivity. First, we propose to construct an addition to the existing Building 12, significantly expanding animal housing and support spaces. This new construction will include animal housing space and innovative caging for 120 additional animals across 6 harems. This addition will also house dedicated support spaces, including an operating room, radiology room, flex holding space for convalescing or pre- sale animals, and a cage washing area, along with personnel spaces such as a staff locker room with connected showers, bathroom, laundry, and PPE donning/doffing area. Second, we propose to install underground fiber optic cable and other network infrastructure to connect the JHU Research Farm facilities to high-speed internet. This project will allow us to fully leverage the soon-to-be-installed JHU-funded upgrades to 1) security and 2) electronic animal health and behavior records. If this proposal is successful, we will better serve the NIH-funded research community that relies on primate models in two key ways: 1) we will increase the number of animals available to researchers and 2) we will evaluate the novel husbandry and behavioral management features designed into the new building and share our findings with NIH-funded nonhuman primate researchers and other national breeding centers.

项目概要 面对有据可查的生物医学非人类灵长类动物持续短缺的情况 研究和证据表明它们可能是 COVID-19 的独特模型，因此毫不奇怪 对猪尾猕猴的需求依然强劲，并持续攀升。自从 NIH 开始以来 2006年，JHU猪尾猴群为生物医学提供了313只动物 研究，其中绝大多数与艾滋病毒/艾滋病有关。其中 172 只动物 (55%) 去约翰霍普金斯大学以外的机构接受 NIH 资助的研究人员，我们已经建立了我们的殖民地 作为国家重要资源的这种宝贵的动物模型。为了满足日益增长的需求 猪尾猕猴在生物医学研究中，我们制定了一项计划，大幅增加 我们可以在 JHU 研究农场饲养的动物数量，并进一步完善我们的研究 对该繁殖群体进行行为管理以提高生产力。首先，我们建议 在现有 12 号楼的基础上增建，显着扩大动物饲养场和 支持空间。这个新建筑将包括动物饲养空间和创新的笼舍 6 个后宫的 120 只额外动物。此次新增还将提供专门的支持 空间，包括手术室、放射室、用于康复或预治疗的灵活保留空间 出售动物、笼子清洗区以及员工储物柜等人员空间 房间配有连通淋浴、浴室、洗衣房和个人防护装备穿脱区。第二，我们 建议安装地下光缆和其他网络基础设施来连接 JHU 研究农场设施配备高速互联网。这个项目将使我们能够充分利用 即将安装的 JHU 资助的升级项目包括 1) 安全性和 2) 电子动物健康和 行为记录。如果这个提案成功，我们将更好地服务于NIH资助的研究 社区以两种主要方式依赖灵长类动物模型：1）我们将增加 可供研究人员使用的动物，2）我们将评估新颖的饲养方式和行为 新大楼设计的管理功能，并与 NIH 资助的机构分享我们的发现 非人类灵长类动物研究人员和其他国家育种中心。