Statistical Analysis Core

统计分析核心

• 批准号: 9094516
• 负责人: Marilyn E. Carroll
• 金额: $ 30.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9094516
• 关键词: Behavior; Behavior Therapy; Clinical Sciences; Clinical Trials Data Monitoring Committees; Cocaine; Cocaine Abuse; Cocaine Dependence; Collaborations; Collection; Communities; Data; Data Analyses; Data Collection; Development; Effectiveness; Enrollment; Ensure; Foundations; Funding Opportunities; Human; Human Resources; Impulsivity; Individual; Information Dissemination; Information Systems; Institutes; Intervention; Investigation; Leadership; Link; Logistics; Mentors; Mentorship; Methodology; Minnesota; Mission; Monitor; Nicotine; Nicotine Dependence; Participant; Pharmaceutical Preparations; Progesterone; Randomized; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Retrieval; Rodent Model; Role; Science; Services; Sex Characteristics; Smoking; Specialized Center; Statistical Data Interpretation; Statistical Methods; Sum; System; Training; Translational Research; Universities; Work; addiction; base; behavioral impairment; cost effective; data management; design; dissemination research; follow-up; innovation; insight; novel; translational study

The Statistical Analysis Core will provide high quality, integrated collaboration in and support of the proposed Center on the role of sex differences on progesterone and impulsivity in cocaine and nicotine addiction. As a foundation for all three proposed projects, this Core will provide: personnel with the appropriate breadth and depth of expertise; services in study design, study logistics planning, data management, and statistical analysis; training and mentoring; and other resources as needed. Core personnel will actively participate with project teams before study initiation, during study execution, and as part of novel cross-project initiatives that will integrate the projects to provide innovative insight into sex differences, progesterone, impulsivity, and addiction. This Core will in particular interact closely and extensively with the Science and Training Core (Core B) and the Administrative Core (Core A) on scientific and management oversight of each project as it is carried out, on the prioritization of SAC work across the needs of the projects, on the ongoing training and mentoring of junior investigators and trainees, and on supporting future research and funding opportunities on sex differences in addiction which are motivated by this proposed Center. Our continuity of involvement, from initial study planning through study completion and into dissemination, will provide a common connection among the projects spanning the entire proposed period. Lastly, we will provide resources for additional exploratory analyses that come to light as the research progresses, taking full advantage of the Center's careful data collection and management, thereby also facilitating the development of innovative hypotheses for future research.

统计分析核心将在拟议中心提供高质量的，综合的协作和支持性别差异对孕激素和冲动性的作用，在可卡因和尼古丁成瘾中的作用。作为所有三个拟议项目的基础，该核心将提供：具有适当广度和深度知识的人员；研究设计，研究物流规划，数据管理和统计分析中的服务；培训和指导；和其他资源。核心人员将在研究启动之前，在研究执行期间以及作为新颖的跨项目计划的一部分之前积极与项目团队一起参与，这些计划将整合项目，以提供对性别差异，孕酮，冲动和成瘾的创新见解。该核心将尤其将与科学和培训核心（核心B）以及对每个项目进行的科学和管理监督的行政核心（核心A）进行紧密相互互动，从而在项目的需求跨项目的优先级排序，在持续的培训和指导初级研究人员和受训者的培训和指导下，以及支持未来的研究和融资，以使性别差异融为一体。我们的参与连续性，从最初的研究计划到研究完成到传播，将在整个拟议时期的项目之间提供共同的联系。最后，我们将提供资源，以进行其他探索性分析，随着研究的进行而揭示，充分利用了该中心的仔细数据收集和管理，从而促进了创新假设的发展，以供未来的研究。