Sex Differences and Progesterone Effects on Impulsivity and Smoking Cessation

性别差异和黄体酮对冲动和戒烟的影响

• 批准号: 8366480
• 负责人: Marilyn E. Carroll
• 金额: $ 13.9万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366480
• 关键词: Addictive Behavior; Address; Animals; Behavior; Behavior Therapy; Centers for Disease Control and Prevention (U.S.); Cigarette Smoker; Clinical; Clinical Data; Cocaine; Cocaine Abuse; Cocaine Dependence; Data; Disease; Double-Blind Method; Effectiveness; Estrogens; Female; Gonadal Steroid Hormones; Hormones; Impulsive Behavior; Impulsivity; Instruction; Intervention; Investigation; Knowledge; Literature; Luteal Phase; Menstrual cycle; Morbidity - disease rate; Nicotine; Nicotine Dependence; Outcome; Pharmaceutical Preparations; Placebos; Play; Principal Investigator; Process; Progesterone; Randomized; Randomized Controlled Trials; Relapse; Relative (related person); Research; Risk; Role; Sampling; Serum; Sex Characteristics; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Tobacco use; United States Dept. of Health and Human Services; Woman; Work; addiction; animal data; behavioral impairment; cigarette smoking; design; disorder prevention; high risk; improved; innovation; male; men; mortality; non-smoker; programs; proliferative phase Menstrual cycle; sex; smoking cessation; smoking relapse; theories

Compared to men, women are at an increased risk of smoking-related morbidity and mortality. Sex hormones have been implicated in both the animal and clinical literature as having an effect on addictive behaviors. In clinical literature on tobacco use, our work along with others has demonstrated that the luteal phase (high progesterone) is associated with decreased smoking-related symtomatology and improved smoking cessation outcomes. These data suggest that progesterone (PRO) may enhance smoking cessation. Impulsivity is another factor that may impact smoking behavior as smokers are typically more impulsive than non-smokers. Further, among those who attempt to quit smoking, those who relapse have higher levels of impulsivity. Interestingly, clinical data indicates the association between impulsivity and smoking behavior may vary by sex. Further, data from the animal literature suggest that PRO may reduce impulsive behavior. Therefore, the objective of this project is to examine the interplay of PRO, impulsivity and sex differences in smoking cessation. Specifically, our primary aim is to investigate sex differences in the effect of exogenous PRO compared to placebo on impulsivity and smoking cessation. We will address this specific aim by conducting a double-blind randomized smoking cessation trial including female and male smokers randomized into one to either active or placebo PRO. The design (paralleling Project II) provides a unique opportunity to delineate sex differences and PRO effects in smoking cessation. If our hypotheses are confirmed, the results of this study could directiy advance the literature on the role of sex hormones in addictive behaviors. Further, this study has the potential to inform new and innovative smoking cessation intervention treatments via the delivery of exogenous hormones. RELEVANCE (See instructions): Despite much effort, there are not yet highly effective approved medications for the direct treatment of cocaine and nicotine dependence. This SCOR will carry out interdisciplinary and translational investigations to identify pharmacological interventions targeting behaviors impaired in nicotine and cocaine dependent subjects to enhance the effectiveness of existing behavioral treatments for addiction.

与男性相比，女性吸烟相关发病率和死亡率的风险更高。性别 动物和临床文献都表明激素对成瘾有影响 行为。在有关烟草使用的临床文献中，我们与其他人一起的工作表明，黄体 阶段（高孕酮）与吸烟相关症状的减少和改善有关 戒烟结果。这些数据表明黄体酮 (PRO) 可能会促进吸烟 停止。冲动是可能影响吸烟行为的另一个因素，因为吸烟者通常更容易冲动。 比不吸烟的人更冲动。此外，在那些试图戒烟的人中，那些复吸的人 更高程度的冲动。有趣的是，临床数据表明冲动和冲动之间存在关联。 吸烟行为可能因性别而异。此外，来自动物文献的数据表明 PRO 可能会减少 冲动行为。因此，该项目的目标是研究 PRO、冲动性之间的相互作用 以及戒烟方面的性别差异。具体来说，我们的主要目标是调查性别差异 与安慰剂相比，外源性 PRO 对冲动和戒烟的影响。我们将解决 通过开展一项包括女性和男性在内的双盲随机戒烟试验来实现这一具体目标 吸烟者被随机分为一组，要么服用活性药物，要么服用安慰剂 PRO。该设计（与项目 II 并行）提供了 这是描述性别差异和戒烟 PRO 效应的独特机会。如果我们的假设是 经证实，这项研究的结果可以直接推进有关性激素在 成瘾行为。此外，这项研究有可能为新的和创新的戒烟提供信息 通过输送外源激素进行干预治疗。 相关性（参见说明）： 尽管付出了很多努力，但尚未有高效的批准药物用于直接治疗 可卡因和尼古丁依赖。该 SCOR 将开展跨学科和转化研究 确定针对尼古丁和可卡因依赖者行为受损的药物干预措施 旨在提高现有成瘾行为治疗的有效性。