A preschool biomarker for literacy

学前识字生物标志物

基本信息

批准号：
9032506
负责人：
NINA KRAUS
金额：
$ 37.37万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2018-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9032506
关键词：
4 year old 8 year old Acoustics Affect Age Attention Auditory Auditory Brainstem Responses Biological Biological Markers Brain Stem Cerebral Dominance Child Code Cognitive Communication Data Development Developmental reading disorder Disease Dyslexia Early Intervention Early identification Electrodes Electrophysiology (science)Elements Employee Strikes Exhibits Failure Financial cost Future Genetic Transcription Goals Head Human Impairment Individual Instruction Intention Intervention Language Lead Learning Life Linguistics Link Literature Longitudinal Studies Machine Learning Measures Memory Modeling Nature Nervous system structure Neurologic Nursery Schools Outcome Pattern Physiological Physiological Processes Physiology Plant Roots Primary Schools Probability Process Publishing Reader Reading Reading Disorder Recording of previous events Research Research Personnel Resources Risk Role Scalp structure School-Age Population Schools Sensory Sensory Process Shapes Signal Transduction Speech Speech Sound Staging Stimulus Synapses Technology Testing Time Transcription Process Work abstracting age group auditory pathway base cognitive function cognitive skill cohort contextual factors corticofugal fiber experience falls intervention program literacy literate neurophysiology peer phonology reading ability reading difficulties relating to nervous system remediation response skills social sound spelling stimulus processing

项目摘要

DESCRIPTION (provided by applicant): As many as one in ten children have the poor reading and spelling skills that comprise developmental dyslexia. It is widely accepted that there is a neurological basis; however, the nature of that basis is hotly debated. Nevertheless, one consistent view is that poor phonological processing-the ability to access and manipulate the sound units of language-is involved in dyslexia. Indeed, a majority of children with reading deficits exhibit difficulties on an array of phonological processing tasks. A growing body of research has discovered that speech-sound transcription, as measured by electrophysiology, shows striking relationships with phonological processing skills and reading ability in school-age children. As such, we have developed a suite of subcortical and cortical physiological tests that probe some of the core deficits that researchers have postulated as the root elements of poor phonological processing. We will target the subcortical processing of time-varying signals and stimulus regularities, and cortical hemispheric specialization to both fast and slow signals. In a longitudinal cohort of four- to eight-year-olds, we will model the normal neurological speech transcription process, quantify its development, and examine its relationship with the development of literacy-related skills. Our intention is that by leveraging these electrophysiological probes to a pre-reading age group, a biomarker, in preschoolers, may be found that predicts a child's eventual reading skill as he/she progresses through the primary grades. If such a biomarker is found, it would pave the way for earlier and more effectively targeted intervention.

描述（由申请人提供）：多达十分之一的孩子的阅读和拼写技巧包括发育障碍。人们普遍认为有神经系统基础。但是，该基础的性质是激烈的辩论。然而，一种一致的看法是，语音处理差 - 能够访问和操纵语言单位的能力 - 涉及阅读障碍的语言单位。实际上，大多数阅读缺陷的儿童在一系列语音处理任务上表现出困难。越来越多的研究发现，通过电生理学来衡量的语音转录表明，与学校时代儿童的语音处理能力和阅读能力的关系显着。因此，我们开发了一套皮层和皮质生理测试的套件，这些测试探测了研究人员认为是语音处理不良的根部元素的一些核心缺陷。我们将靶向时变信号和刺激规律性的皮层下处理，以及皮质半球专业化的快速和缓慢信号。在四到八岁的纵向队列中，我们将对正常的神经学语音转录过程进行建模，量化其发展，并检查其与扫盲相关技能的发展的关系。我们的目的是，通过利用这些电生理探测器到预读年龄段，可以发现在学龄前儿童中的生物标志物，可以预测孩子/她通过初级成绩的最终阅读技能。如果发现这样的生物标志物，它将为更早，更有效的靶向干预铺平道路。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Auditory-neurophysiological responses to speech during early childhood: Effects of background noise.

DOI：
10.1016/j.heares.2015.06.009
发表时间：
2015-10
期刊：
Hearing research
影响因子：
2.8
作者：
White-Schwoch T;Davies EC;Thompson EC;Woodruff Carr K;Nicol T;Bradlow AR;Kraus N
通讯作者：
Kraus N

Hemispheric Asymmetry of Endogenous Neural Oscillations in Young Children: Implications for Hearing Speech In Noise.

幼儿内源性神经振荡的半球不对称：对噪声中听力言语的影响。

DOI：
10.1038/srep19737
发表时间：
2016
期刊：
Scientific reports
影响因子：
4.6
作者：
Thompson,ElaineC;WoodruffCarr,Kali;White-Schwoch,Travis;Tierney,Adam;Nicol,Trent;Kraus,Nina
通讯作者：
Kraus,Nina

Sex differences in subcortical auditory processing only partially explain higher prevalence of language disorders in males.

DOI：
10.1016/j.heares.2020.108075
发表时间：
2020-12
期刊：
Hearing research
影响因子：
2.8
作者：
Krizman J;Bonacina S;Kraus N
通讯作者：
Kraus N

Continued maturation of the click-evoked auditory brainstem response in preschoolers.

DOI：
10.3766/jaaa.26.1.4
发表时间：
2015-01
期刊：
Journal of the American Academy of Audiology
影响因子：
1.2
作者：
Spitzer E;White-Schwoch T;Carr KW;Skoe E;Kraus N
通讯作者：
Kraus N

Multiple Cases of Auditory Neuropathy Illuminate the Importance of Subcortical Neural Synchrony for Speech-in-noise Recognition and the Frequency-following Response.

多个听觉神经病变病例阐明了皮质下神经同步对于噪声中语音识别和频率跟随响应的重要性。

DOI：
10.1097/aud.0000000000001122
发表时间：
2022
期刊：
Ear and hearing
影响因子：
3.7
作者：
White-Schwoch,Travis;Anderson,Samira;Krizman,Jennifer;Bonacina,Silvia;Nicol,Trent;Bradlow,AnnR;Kraus,Nina
通讯作者：
Kraus,Nina