SPEECH EVOKED CORTICAL ERPS IN COCHLEAR IMPLANTS USERS

人工耳蜗使用者的言语诱发皮质 ERPS

• 批准号: 2126953
• 负责人: NINA KRAUS
• 金额: $ 15.42万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2126953
• 关键词: auditory discrimination; auditory stimulus; behavior test; cochlear implants; discrimination learning; evoked potentials; human subject; human therapy evaluation; longitudinal human study; perception; psychoacoustics; sound frequency; speech; speech synthesizers

DESCRIPTION: (Adapted From The Applicant's Abstract.) The degree of success and satisfaction experienced by cochlear-implant recipients varies greatly and is influenced significantly by the individual's ability to understand speech. It is hypothesized that the wide range of speech perception skills exhibited by cochlear-implant patients may be attributed, in part, to differences in central auditory processing abilities or in the capacity of the central auditory system to adapt to electrical stimulation. It is proposed to characterize speech-evoked cortical potentials in order to develop an objective measure of central auditory function in implant users. The long-term aim of this research is to develop a clinically feasible battery of speech--evoked electrophysiologic measures that can be used to evaluate the function of cochlear implants in deaf individuals. Optimally, that non-invasive test battery will be useful in assessing implant performance in patients who cannot undergo conventional behavioral testing (e.g. young children) and in providing a neurophysiologic basis for the design of rehabilitation programs and future implant signal-processing strategies. Specifically, the mismatch negativity (MMN)- a passively elicited evoked potential that reflects the cortical processing of fine acoustic stimulus differences - and the P300 cognitive potential will be investigated. Synthesized pairs of speech stimuli with well-defined acoustic parameters will be used to elicit the MMN and P300 in normal-hearing listeners and cochlear-implant patients to characterize the central neurophysiologic processes underlying normal and cochlear-implant-mediated speech perception. Those responses will be correlated with behavioral speech discrimination and related to clinical measures of speech perception and implant success. A subset of newly implanted adults and children will undergo the same battery of tests periodically for 12 months immediately after implantation to assess short-term longitudinal changes in electrophysiologic responses, auditory discrimination, and speech perception.

描述：（改编自申请人的摘要。） 人工耳蜗植入者所经历的成功和满意度各不相同 很大程度上取决于个人的能力 听懂言语。 据推测，言语的范围很广 人工耳蜗患者表现出的感知能力可能归因于， 部分原因是中枢听觉处理能力或听觉能力的差异 中枢听觉系统适应电刺激的能力。 建议表征语音诱发的皮层电位，以便 开发植入物中枢听觉功能的客观测量方法 用户。 本研究的长期目标是开发一种临床 可行的言语电池——诱发电生理测量 用于评估聋人人工耳蜗的功能。 最理想的是，非侵入性测试电池将有助于评估 无法接受常规行为的患者的种植体性能 测试（例如幼儿）并提供神经生理学基础 康复计划和未来植入物信号处理的设计 策略。 具体来说，失配负性（MMN）——一种被动诱发的诱发因素 反映精细声刺激的皮层处理的电位 差异 - 并且将调查 P300 认知潜力。 具有明确定义的声学参数的合成语音刺激对 将用于在正常听力听众中引出 MMN 和 P300， 人工耳蜗植入患者的中枢神经生理学特征 正常和人工耳蜗介导的言语的基础过程 洞察力。 这些反应将与行为言语相关 歧视和与言语感知的临床测量有关的 植入成功。 新植入的成人和儿童的一部分将 立即在 12 个月内定期进行相同的一系列测试 植入后评估短期纵向变化 电生理反应、听觉辨别和言语 洞察力。