Development of Sensitivity to Acoustic Modulation in Infants who use Cochlear Implants

使用人工耳蜗的婴儿对声学调制的敏感性的发展

• 批准号: 10606617
• 负责人: David Louis Horn
• 金额: $ 69.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606617
• 关键词: 10 year old; 4 year old; 8 year old; Acoustics; Address; Adult; Age; Auditory; Auditory Perception; Child; Chronology; Clinical; Clinical Management; Cochlear Implants; Communication; Development; Devices; Early Intervention; Early identification; Early treatment; Frequencies; Goals; Habilitation; Hearing; Implant; Individual; Infant; Intervention; Lead; Longitudinal Studies; Measures; Methods; Modification; Noise; Outcome; Patients; Pattern; Perception; Peripheral; Procedures; Psychoacoustics; Research; Resolution; Signal Transduction; Speech; Speech Perception; Speech Sound; Testing; Time; Work; auditory deprivation; behavior test; clinical care; congenital hearing loss; deaf; experience; experimental study; hearing impairment; implantation; infancy; normal hearing; oral communication; postnatal; programs; skills; temporal measurement

PROJECT SUMMARY/ABSTRACT The ability of patients with cochlear-implants (CI) to discriminate speech sounds is the fundamental measure of efficacy that clinicians use to create personalized clinical interventions. Given the universal importance of early identification and treatment for children born with hearing loss, the most appropriate clinical intervention for children with CIs should be initiated at the earliest possible age. Despite the routine implantation of prelingually-deaf infants as young as 9-months-old, there are currently no established clinical measures of CI efficacy for children younger than approximately 4-years-old. The long-term goal of the proposed research is to develop new measures of device efficacy in cochlear-implanted infants that can be used to drive clinical decisions at a much earlier age than is currently possible. The ability to perceive patterns of temporal or spectral intensity modulation in a noise, or “acoustic modulation perception”, is known to predict speech understanding in adult CI users. In previous work, the PI adapted tests of acoustic modulation perception for testing infants and young children. The next step, proposed in this application, will be to investigate how acoustic modulation perception develops, and relates to speech perception, in implanted infants. This will involve examining the development of two independent factors with markedly different trajectories: the ability to resolve the spectral place or timing of modulation, and sensitivity to intensity modulation across frequency or time. The central hypothesis is that both normal hearing and implanted infants will show an asymmetry in development of these factors. Frequency and temporal resolution is expected to mature by 6-months postnatal hearing-age whereas sensitivity to intensity modulation is expected to remain immature through 7-10 years old. The basis for this hypothesis is that frequency and temporal resolution reflect early-developing peripheral auditory mechanisms whereas sensitivity to intensity modulation reflects later-developing central auditory mechanisms. There are 3 specific aims to this proposal. The first is to characterize the developmental trajectory for frequency and temporal resolution in implanted and normal hearing infants during the first 6 months of post- natal hearing experience. The second is to compare the developmental trajectory of spectral and temporal modulation sensitivity in children implanted during infancy with that of normal hearing children through 10- years-of-age. The third is to determine if frequency and temporal resolution independently predict speech perception outcomes in implanted children. This work is a necessary step toward the goal of developing age- appropriate, nonlinguistic measures of acoustic modulation perception that reflect CI efficacy in implanted infants. If the long-term goal of the proposed research is realized, the positive impact will be to enable earlier, more effective, clinical interventions for young patients who use CIs.

项目摘要/摘要 人工耳蜗（CI）歧视语音的患者的能力是基本 临床医生用来创建个性化临床干预措施的效率的度量。给定通用 早期识别和治疗对听力损失的儿童的重要性，这是最合适的临床 对带有独联体的儿童的干预应尽早开始。尽管有例行 植入年仅9个月大的初中婴儿的植入，目前尚无临床 大约4岁以下的儿童的CI效率度量。长期目标 拟议的研究是在人工耳蜗植入婴儿中开发新的设备效率措施，可以是 用于在比目前可能更早的时间内提出临床决策。 在噪声中感知临时或光谱强度调制模式的能力，或者“声学” 众所周知，调制感知”可以预测成人CI使用者的语音理解。在先前的工作中，PI 对婴儿和幼儿测试的声学调节感知的适应测试。下一步， 在本应用程序中提出的是，将研究声学调制感知的发展和与 植入婴儿的语音感知。这将涉及研究两个独立的发展 具有明显不同轨迹的因素：解决调制的光谱位置或时机的能力，以及 对频率或时间的强度调制的敏感性。中心假设是正常听力 植入的婴儿将在这些因素的发展中显示出不对称性。频率和临时 预计分辨率将在产后听力年龄6个月成熟，而对强度调节的敏感性 预计将在7-10岁之前保持不成熟。该假设的基础是频率和 临时分辨率反映了早期开发的外围听觉机制，而对强度的敏感性 调制反映了后来发展的中央听觉机制。 该提案有3个具体目标。首先是表征 植入和正常听力婴儿的频率和临时分辨率 出生的听力经验。第二个是比较光谱和临时的发展轨迹 在婴儿期植入的儿童的调节敏感性与正常听力儿童通过10- 年龄。第三是确定频率和临时分辨率是否独立预测语音 植入儿童的感知结果。这项工作是朝着发展年龄的目标的必要步骤 - 反映植入的CI效率的声学感知的适当的非语言测量 婴儿。如果实现了拟议研究的长期目标，那么积极的影响将是早些时候启用， 对于使用CI的年轻患者，更有效的临床干预措施。