Non-medical use of prescription stimulants for weight loss in adolescents

处方兴奋剂在青少年减肥中的非医疗用途

• 批准号: 9068658
• 负责人: Amy June Jeffers
• 金额: $ 2.58万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-07 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9068658
• 关键词: 12 year old; Adderall; Address; Adolescence; Adolescent; Adverse effects; Alcohol or Other Drugs use; Analysis of Covariance; Appearance; Attention deficit hyperactivity disorder; Attitude; Awareness; Behavior; Blood Pressure; Body Weight decreased; Categories; Cognition; Data; Desire for food; Development; Disease; Drug Prescriptions; Drug Use Disorder; Drug usage; Eating; Eating Behavior; Eating Disorders; Emergency department visit; Empirical Research; Foundations; Future; Goals; Health; Health behavior; Individual; Intervention; Interview; Knowledge; Literature; Malnutrition; Marijuana; Medical; Methodology; Motivation; Multivariate Analysis; Normalcy; Outcome; Participant; Perception; Pharmaceutical Preparations; Planning Theory; Population; Prevalence; Prevention; Prevention program; Preventive Intervention; Psychopathology; Public Health; Qualitative Methods; Reporting; Research; Research Personnel; Risk; Ritalin; Role; Sampling; Solid; Staging; Substance Use Disorder; Suggestion; Survey Methodology; Surveys; Testing; Time; Training; Weight; Weight maintenance regimen; Youth; age group; behavioral construct; career; depressive symptoms; drug misuse; experience; health data; high risk; illicit drug use; insight; non-drug; novel; psychosocial; public health relevance; recreational drug use; self esteem; social norm; stimulant misuse; young adult

 DESCRIPTION (provided by applicant): There has been a dramatic increase in the non-medical use of prescription drugs (NMUPD; i.e., without a doctor's prescription) among young adults and adolescents. In 2011, NMUPD was the second most prevalent category of illicit drug use in these age groups, following marijuana. Indeed, NMUPD is involved in more emergency room (ER) visits than use of all illicit substances combined. The recent rise in the non-medical use of prescription stimulants (NMUPS), medications used to treat Attention Deficit Hyperactivity Disorder (ADHD), such as Adderall and Ritalin, is particularly concerning. ER visits related to misuse of these drugs has more than tripled between 2005 and 2010. One relevant concern regarding stimulant misuse, especially with adolescents, is their role in appetite suppression. Given the increasing number of adolescents who report engaging in weight loss behaviors, misuse of stimulants for weight control might appeal to some youth. However, there has been minimal empirical research on this topic, and the majority has exclusively included young adults. NMUPS for weight loss is associated with other substance use, disordered eating behaviors, and psychopathology. Because adolescents are the second largest age group to engage in NMUPS, and they are at high risk for disordered eating behaviors, research is warranted to examine this phenomenon in this age group. Thus, the proposed research will examine this behavior in a sample of adolescents using both survey and qualitative methods. Constructs assessed will include: NMUPS and motivations, consequences associated with NMUPS, medication knowledge, other recreational drug use, disordered eating, psychopathology, and Theory of Planned Behavior (TPB) constructs: attitudes, subjective norms, and perceived control related to NMUPS for weight loss. Key hypotheses are as follows: 1) at least some participants will report NMUPS for weight loss; 2) individuals who engage in NMUPS for weight loss will also engage in more problematic health behaviors and have poorer psychosocial health compared to those who are trying to lose weight without engaging in NMUPS, and those who are not trying to lose weight; 3) these individuals will demonstrate maladaptive cognitions, including higher perceived normality of the behavior and less knowledge about the dangers of such misuse. A multivariate analysis of covariance, correlations, regressions, chi-squares, and thematic analysis of qualitative data will be used to test these hypotheses. Results will provide insight into which modifiable factors are most strongly associated with NMUPS for weight loss, informing awareness, prevention, and intervention efforts. This project will also provide a solid foundation for my research career and facilitate my transition to research independence.

 描述（由适用提供）：年轻人和青少年在非医学使用处方药（nmupd;即没有医生处方）的非医学使用急剧增加。在2011年，NMUPD是这些年龄段的非法药物使用的第二大普遍类别，继大麻之后。确实，NMUPD参与了急诊室（ER）的访问，而不是使用所有非法物质的使用。在非医学使用处方刺激剂（NMUP）中，最近用于治疗注意力缺陷多动障碍（ADHD）（例如Adderall和Ritalin）的药物尤为关注。在2005年至2010年之间，与这些药物有关的急诊就诊的访问量增加了两倍以上。关于兴奋的小姐，尤其是与青少年的相关关注点是它们在食欲抑制中的作用。鉴于越来越多的青少年报告从事减肥行为，因此某些年轻人可能会出现对体重控制的兴奋剂。但是，关于该主题的实证研究最少，大多数人仅包括年轻人。减肥的NMUP与其他药物使用，饮食行为无序和心理病理学有关。由于青少年是参与NMUP的第二大年龄段，并且他们的饮食行为无序风险很高，因此有必要进行研究以检查该年龄段的这种现象。这是拟议的研究将使用调查和定性方法在青少年样本中检查这种行为。评估的结构将包括：NMUP和动机，与NMUP相关的后果，药物知识，其他娱乐性药物使用，饮食不足，精神病理学和计划行为的理论（TPB）结构：吸引人，主观规范以及与NMUP有关体重减轻的感知控制。关键假设如下：1）至少有些参与者将报告减肥的NMUP； 2）与那些试图减肥而不参与NMUP的人，以及那些没有尝试减肥的人相比，从事减肥的个人也将进行更多问题的健康行为，并具有较差的社会心理健康。 3）这些人将表现出适应不良的认知，包括对行为的更高的正常性以及对这种滥用危险的了解。对协方差，相关性，回归，卡方和定性数据的主题分析的多元分析将用于检验这些假设。结果将提供有关哪些可修改因素与减肥的NMUP最密切相关的因素，以告知意识，预防和干预工作。该项目还将为我的研究职业提供坚实的基础，并促进我向研究独立性的过渡。