2022 Membrane Transport Proteins GRC/GRS

2022 膜转运蛋白 GRC/GRS

基本信息

批准号：
9991402
负责人：
AURELIO GALLI
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9991402
关键词：
Academia Academy Adderall Address Advocacy Animal Model Anniversary Area Attention deficit hyperactivity disorder Australia Basic Science Biochemical Biogenesis Biological Biophysics Brain Canada Carrier Proteins Cells Cessation of life Christianson syndrome Climate Clinical Collaborations Communities Cystic Fibrosis Data Defect Development Diabetes Mellitus Discipline Disease Diuretics Ensure Environment Europe Fluoxetine Fostering Functional disorder Future Genes Genetic Genetic Diseases Goals Government Hour Human Genome Industry International Invertebrates Ion Channel Ion Pumps Ions Knowledge Lead Leadership Life Link Malignant Neoplasms Medical Medicine Membrane Potentials Membrane Transport Proteins Mental Depression Mentors Metabolic Migraine Mind Minority Molecular Nerve Degeneration Neurologic Neurons Neurotransmitters Nuclear Pore Nutrient Omeprazole Organism Participant Patients Perception Pharmaceutical Preparations Pharmacology Pharmacotherapy Physiological Physiology Policies Postdoctoral Fellow Process Protein translocation Proteins Proton Pump Publishing Rare Diseases Regulation Reporting Research Research Personnel Ritalin SK-Furosemide Science Science, Technology, Engineering and Mathematics Scientist Secondary Schools Secure Selective Serotonin Reuptake Inhibitor Sodium Chloride System Techniques Therapeutic Time Transcranial magnetic stimulation Translating Transmembrane Transport Ulcer Underrepresented Minority Woman Work autism spectrum disorder base career clinically relevant design disease phenotype diversity and inclusion dopamine transporter drug discovery equity diversity and inclusion gender equity genetic variant graduate student improved inhibitor/antagonist innovation insight lectures member neurotransmitter release next generation notch protein novel outreach peer peptide hormone posters prevent programs rare genetic disorder recruit serotonin transporter single-molecule FRET skills success supportive environment symporter symposium therapeutic target trafficking

项目摘要

PROJECT SUMMARY The 2020 Gordon Research Conference on Membrane Transporter Proteins titled “Biomedical Transporters: Physiology, Dysfunction and Targets of Pharmacotherapy” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and thought contribute to a gamut of highly prevalent (autism, depression, diabetes) as well as orphan and rare diseases (Christianson syndrome, mucoviscidosis), membrane transporters remain largely unexplored in their potential as therapeutic targets, and in their association to specific diseases. The impetus in organizing this conference is to link genetic, molecular and mechanistic insights on clinically important membrane transporters, including carriers, ion channels and pumps, to physiological function and disease-related malfunction. The intent is to offer and discuss opportunities for the development of pharmacotherapies targeting transporter dysfunctions in disease states. N ine highly interdisciplinary scientific sessions are bringing together topics, approaches and novel ideas that are not conventionally related. These range from genetics of transporter and ion channels in disease states, to unconventional animal models to study transporter, or particular approaches such as single-molecule fluorescence resonance energy transfer and transcranial magnetic stimulation. This prevents the perception of a particular approach or topic dominating the conference and amplifies opportunities for discussion of new ideas. New topics have been introduced (e.g. peptides, hormones, and neurotransmitter release: the importance of transporters in the gut and brain; invertebrates as animal models to study transporter functions, etc.) that have never been covered in this conference. Ample discussion time after each talk, daily posters, and afternoon free time allow for informal discussion, networking and forming new collaborations. Other special features of the 2020 conference include the Gordon Research Seminar for young investigators, and the Power Hour for the promotion of women scientists. Notably, we secured Dr. Imogen Coe as the Discussion Leader of the Power Hour. Dr. Coe is internationally recognized as a Canadian thought leader in the area of equity, diversity and inclusion (EDI) in science, technology, engineering and math (STEM). She has advised academia, government and industry on the best practices and approaches to improve EDI in STEM, particularly in the Canadian post-secondary education (PSE) sector. She has written and spoken about these issues extensively for platforms such as the Globe and Mail, iPolitics and the CBC. In 2016, she was recognized as one of Canada's Top 100 Women for her advocacy work promoting equity in STEM. We feel that this conference will offer plenty of scientific opportunities fostering an environment centered on EDI.

项目摘要 2020年戈登膜转运蛋白蛋白的研究会议名为“生物医学转运蛋白：生理学，功能障碍和药物疗法的靶标”将迫切需要翻译重点研究临床相关且高度可吸毒的膜转运蛋白。尽管他们占10％人类的基因组和思想也有助于高度普遍（自闭症，抑郁症，糖尿病）由于孤儿和罕见疾病（克里斯蒂安森综合症，粘膜粘膜病），膜转运蛋白仍然很大出乎意料的是，它们作为治疗靶标的潜力以及与特定疾病的关联。推动力组织这次会议是将临床上重要膜上的遗传，分子和机械见解联系起来转运蛋白，包括载体，离子通道和泵，与身体机能和疾病有关故障。目的是提供和讨论针对药物治疗的开发机会疾病状态中的转运蛋白功能障碍。 n 在高度跨学科的科学会议中主题，方法和新思想在常规上无关。这些范围从转运蛋白的遗传学疾病状态中的离子通道，非常规动物模型研究转运蛋白或特定的动物模型诸如单分子荧光共振能量转移和经颅磁的方法刺激。这阻止了对会议主导的特定方法或主题的看法，并且放大器讨论新想法的机会。已经引入了新主题（例如肽，激素，和神经递质释放：转运蛋白在肠道和大脑中的重要性；无脊椎动物作为动物模型研究转运蛋白功能等）在这次会议上从未涵盖过。充足的讨论时间每次谈话后，每日海报和下午的空闲时间都可以进行非正式的讨论，网络和形成新的协作。 2020年会议的其他特殊功能包括戈登的年轻研究研讨会调查人员以及促进女科学家的力量时光。值得注意的是，我们确保了Imogen Coe博士作为权力时光的讨论负责人。 Coe博士在国际上被公认为是加拿大思想领袖在科学，技术，工程和数学（STEM）中的公平，多样性和包容性（EDI）领域。她已向学术界，政府和工业提供了有关改善STEM EDI的最佳实践和方法的建议，特别是在加拿大大专教育（PSE）部门。她已经写了这些对于地球和邮件，iPolitics和CBC等平台的广泛问题。 2016年，她被认可作为加拿大前100名女性之一，她的倡导工作促进了STEM的股权。我们觉得这个会议将为以EDI为中心的环境提供许多科学机会。