Strengthening the ISMMS research and response capabilities for pathogens of pandemic potential

加强 ISMMS 对大流行病原体的研究和应对能力

基本信息

批准号：
10611770
负责人：
Randy A. Albrecht
金额：
$ 231.45万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10611770
关键词：
Address Air Animals Antiviral Agents Area Basic Science Biological Biology Biomedical Research Bunyavirales COVID-19 pandemic Cell Culture Techniques Chemicals Communicable Diseases Communities Contracts Coronavirus Decontamination Department of Defense Development Devices Engineering Ensure Faculty Family Family Picornaviridae Filovirus Flaviviridae Funding Grant Health system Hospitals Image Immunoassay Industry Infectious Diseases Research Influenza Infrastructure Institution International Investigation Laboratories Lead Medical Microbiology Modernization New York City Paramyxovirus Pathogenesis Pathogenicity Patient Care Peer Review Protocols documentation Public Health Publications RNA RNA Viruses Reader Research Research Personnel Research Project Grants Resource Sharing Resources Safety System Togaviridae Training Translational Research Travel U-Series Cooperative Agreements United States National Institutes of Health Virulent Virus Virus Diseases Vision Work animal model development authority biocontainment facility biosecurity drug discovery emerging pathogen exhaust improved influenzavirus instrument medical countermeasure medical schools member metropolitan novel operation pandemic disease pandemic preparedness pathogen pathogenic virus pre-clinical programs recombinant virus research and development response vector-borne

项目摘要

The Icahn School of Medicine at Mount Sinai (ISMMS) is an international leader in medical and scientific training, biomedical research, and patient care. The ISMMS is the medical school for the Mount Sinai Health System (MSHS), which includes eight hospital campuses within the New York City metropolitan area that is a major focal point of international travel. The MSHS leveraged its large metropolitan footprint by establishing pathogen discovery and pandemic surveillance activities. The Department of Microbiology maintains robust research programs that are focused on investigating the biology of new and emerging RNA viruses with pandemic potential and developing novel medical countermeasures against these RNA that are focus of the NIH Antiviral Program for Pandemics (APP). These research programs include pandemic preparedness efforts focused seven RNA virus families or orders of greatest pandemic concern, i.e., Bunyavirales, Coronaviridae, Filoviridae, Flaviviridae, Paramyxoviridae, Picornaviridae, and Togaviridae. Since 2017, faculty members of the Department of Microbiology have co-authored over 250 peer-reviewed publications on these viral pathogens of public health concern. The Department of Microbiology is internationally recognized for its influenza research programs, including investigation of highly pathogenic influenza viruses that require enhanced biocontainment facilities and safety protocols. The BSL-3/ABSL-3 biocontainment facilities are essential shared resources that ensure biosafety and biosecurity of RNA viruses of significant public health concern and to safely conduct research investigating the biology of viral pathogens with pandemic potential. Our application is focused on infrastructure improvements to modernize three biocontainment facilities to improve biosafety, improve efficiency of operations, and expand research capabilities. The first aim of the infrastructure improvements focus on upgrades of the HVAC, autoclaves, biological safety cabinets, and ventilated animal caging systems to modernize and improve the efficiency of operations of the biocontainment facilities. The second aim of the infrastructure improvements to improve biocontainment research workflow on pathogens with pandemic potential focus, including BioTek multimode microplate readers, imaging stations, and a Luminex platform for multiplex immunoassays.

西奈山伊坎医学院 (ISMMS) 是医学和科学领域的国际领先者培训、生物医学研究和患者护理。 ISMMS 是西奈山健康中心的医学院系统 (MSHS)，包括纽约市大都市区内的八个医院院区，是一个国际旅行的主要焦点。 MSHS 通过建立病原体发现和流行病监测活动。微生物学系保持强劲专注于研究新兴 RNA 病毒生物学的研究项目大流行的潜力并针对这些 RNA 开发新的医疗对策，这是人们关注的焦点 NIH 流行病抗病毒计划 (APP)。这些研究计划包括大流行病防备工作重点关注了最受大流行关注的七个 RNA 病毒家族或目，即布尼亚病毒目、冠状病毒科、丝状病毒科、黄病毒科、副粘病毒科、小核糖核酸病毒科和披膜病毒科。 2017年以来，学院教师微生物学系与人合着了 250 多篇关于这些病毒病原体的同行评审出版物公共卫生问题。微生物学系因其流感研究而获得国际认可计划，包括调查需要加强生物防护的高致病性流感病毒设施和安全协议。 BSL-3/ABSL-3 生物防护设施是重要的共享资源，确保具有重大公共卫生问题的 RNA 病毒的生物安全和生物安保，并安全地进行研究调查具有大流行潜力的病毒病原体的生物学。我们的应用程序专注于改善基础设施，对三个生物防护设施进行现代化改造，以提高生物安全、改善运营效率，并扩大研究能力。基础设施改善的首要目标重点升级暖通空调、高压灭菌器、生物安全柜和通风动物笼养系统实现生物防护设施现代化并提高其运营效率。第二个目标是改善基础设施以改善大流行病原体的生物防护研究工作流程潜在的焦点，包括 BioTek 多模式酶标仪、成像站和 Luminex 平台多重免疫分析。