HIV Persistence: Pathogenesis and Eradication

HIV 持续存在：发病机制和根除

• 批准号: 9065042
• 负责人: DAVID L. WOODLAND
• 金额: $ 1.86万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9065042
• 关键词: AIDS prevention; AIDS/HIV problem; Academia; Address; Affect; Antiviral Agents; Area; Attention; Biological Models; Biology; California; Cells; Clinical; Clinical Trials; Collaborations; Communities; Development; Disease remission; Educational workshop; Fostering; Gap Junctions; Genetic Transcription; HIV; HIV Infections; HIV resistance; HIV vaccine; Health; Human; Immune; Immune response; Immunology; Individual; Industry; Infection; Inflammatory Response; International; Intervention; Joints; Knowledge; Lead; Light; Link; Measurable; Methodology; Outcome; Pathogenesis; Pathologic; Pathology; Patients; Pharmaceutical Preparations; Physicians; Primary Infection; Research; Research Personnel; Scientist; Students; Therapeutic; Therapeutic Intervention; Viral; Viral Genome; Virus; Virus Latency; antiretroviral therapy; clinical practice; improved; in vivo; industry partner; insight; interest; latent infection; meetings; memory CD4 T lymphocyte; next generation; novel; novel therapeutic intervention; novel therapeutics; particle; posters; programs; public health relevance; success; symposium; viral RNA; virology

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled HIV Persistence: Pathogenesis and Eradication, organized by David M. Margolis, Satya Dandekar and Susana T. Valente. The meeting will be held in Olympic Valley, California from March 20-24, 2016. Despite the clinical success of antiretroviral therapy (ART), every day there are more people newly infected with HIV than those initiating ART. The complexities of dispensing lifelong ART for HIV-infected individuals make it imperative to develop strategies for HIV eradication, or at least to strictly control the virus without daily therapy. The clearance of a retroviral infection is a herculean task and requires unraveling the mechanisms of viral persistence and host immune interactions. Further, ART does not appear to completely mitigate the impact of HIV infection on human health, and a better understanding of the overt and subtle immune pathologies induced by HIV infection is needed. Recent studies of early therapeutic interventions and HIV-resistant cellular therapies have provided new insights into the development of HIV eradication strategies. This meeting will focus on all aspects of HIV persistence and eradication that include: 1) The understanding of persistent HIV infection; 2) Innate defenses against retroviral infection; 3) The interplay of the host inflammatory response and HIV pathogenesis; and 4) Novel concepts for viral eradication. Special attention will be paid to progress in the development of model systems to study latent infection as well as strategies to eradicate it. Emphasis will be placed on new, unpublished findings that will highlight novel insights and creative strategies to develop effective control an eradication of HIV infection. Opportunities for interdisciplinary interactions will be significantl enhanced by the concurrent meeting on HIV Vaccines, which will share Keynote addresses and two plenary sessions with this meeting.

 描述（应用程序提供）：请求支持Keystone研讨会的支持，标题为“ HIV持久性：发病机理和消除”，由David M. Margolis，Satya Dandekar和Susana T. Valente组织。该会议将于2016年3月20日至24日在加利福尼亚州的奥林匹克谷举行。尽管抗逆转录病毒疗法（ART）的临床成功，但每天都有新近感染HIV的人比那些发起的艺术更多的人更多。为艾滋病毒感染的个体分配终身艺术的复杂性使得必须制定消除艾滋病毒的策略，或者至少在没有日常治疗的情况下严格控制病毒。逆转录病毒感染的清除是一项艰巨的任务，需要阐明病毒持久性和宿主免疫学相互作用的机制。此外，ART似乎并没有完全减轻HIV感染对人类健康的影响，并且需要更好地了解HIV感染引起的明显和微妙的免疫学。关于早期治疗干预措施和耐HIV的细胞疗法的最新研究已提供 对艾滋病毒辐射策略发展的新见解。这次会议将重点关注艾滋病毒持久性和辐射的各个方面，其中包括：1）对持续性艾滋病毒感染的理解； 2）对逆转录病毒感染的先天防御； 3）宿主炎症反应和HIV发病机理的相互作用； 4）病毒辐射的新概念。将特别关注模型系统开发的进步，以研究潜在感染以及对其进行放疗的策略。重点将放在新的未发表的发现上，这些发现将重点介绍新的见解和创造性策略，以开发有效控制艾滋病毒感染。艾滋病毒疫苗的并发会议将大大增加跨学科互动的机会，艾滋病毒疫苗将在本次会议上共享主题演讲和两次全体会议。