Heart Failure: Genetics, Genomics and Epigenetics

心力衰竭：遗传学、基因组学和表观遗传学

• 批准号: 9049783
• 负责人: DAVID L. WOODLAND
• 金额: $ 1.2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2016-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9049783
• 关键词: Address; Architecture; Bioinformatics; Biological Markers; Biological Models; Biology; Biotechnology; Cardiac development; Cells; Clinical; Collaborations; Communities; Data Set; Diagnosis; Diastolic heart failure; Disease; Disease Progression; Disease model; Epidemic; Epigenetic Process; Etiology; Genes; Genetic; Genomics; Heart failure; Human; Industry; Investments; Joints; Knowledge; Methodology; MicroRNAs; Molecular; Muscle Cells; Natural regeneration; Outcome; Participant; Pathogenesis; Pharmacologic Substance; Predisposition; Research; Research Personnel; Role; Scientist; Signal Pathway; Therapeutic; Time; Training Programs; Translations; Treatment Cost; Utah; Work; base; catalyst; clinical practice; cooking; human disease; induced pluripotent stem cell; innovation; insight; meetings; novel strategies; posters; prevent; programs; repaired; stem cell therapy; symposium

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Heart Failure: Genetics, Genomics and Epigenetics, organized by Stuart A. Cook, Christine E. Seidman and Yigal M. Pinto. The meeting will be held in Snowbird, Utah from April 3-7, 2016. Heart failure (HF) is a worldwide epidemic with treatments costing tens of billions of dollars every year. Despite this investment, HF therapies have limited efficacy in reducing disease progression. Recent insights in fundamental myocyte biology, HF etiologies and pathogenic mechanisms are propelling new strategies to treat and prevent HF. This meeting will explore biologic and technical advances that inform the genetic architecture, molecular pathogenesis and innovative approaches to treat HF. This comes at a time when very large human HF datasets are available and can be interrogated using advanced computational and bioinformatic approaches. Specific aims are to: 1) Consider genes, molecules, signaling pathways and biomarkers involved in systolic and diastolic HF in humans; 2) Explore disease mechanisms underlying HF in model systems; 3) Understand the role of epigenetics, miRNAs and lncRNAs in HF pathogenesis; and 4) Review translational programs in genomic, pharmacologic and cell-based therapeutics to treat HF. The outcomes of this meeting should be far-reaching for basic, translational and clinical communities. The meeting should also provide an excellent training program for junior scientists and serve as a catalyst for collaboration among research, clinical and industrial participants. This meeting is being held in conjunction with the Cardiac Development, Regeneration and Repair meeting that provides an outstanding opportunity for joint sessions in genetics, iPSC disease modeling, stem cell therapeutics and epigenetics.

 描述（由申请人提供）：请求支持题为“心力衰竭：遗传学、基因组学和表观遗传学”的 Keystone 研讨会，由 Stuart A. Cook、Christine E. Seidman 和 Yigal M. Pinto 组织。该会议将在 Snowbird 举行。犹他州，2016 年 4 月 3 日至 7 日。心力衰竭 (HF) 是一种全球性流行病，每年的治疗费用高达数百亿美元，尽管有这样的投资，但心力衰竭疗法在减少疾病方面的功效有限。关于基本肌细胞生物学进展、心力衰竭病因和致病机制的最新见解正在推动治疗和预防心力衰竭的新策略。本次会议将探讨为心力衰竭治疗的遗传结构、分子发病机制和创新方法提供信息的生物学和技术进展。当非常大的人类心力衰竭数据集可用并且可以使用先进的计算和生物信息学方法进行查询时，具体目标是：1）考虑涉及收缩和舒张的基因、分子、信号通路和生物标志物。人类心力衰竭；2) 探索模型系统中心力衰竭的疾病机制；3) 了解表观遗传学、miRNA 和 lncRNA 在心力衰竭发病机制中的作用；4) 审查治疗心力衰竭结果的基因组、药理学和细胞疗法的转化方案。这次会议应该对基础、转化和临床界产生深远的影响。会议还应该为初级科学家提供优秀的培训计划，并成为研究、临床和工业参与者之间合作的催化剂。该会议与心脏发育、再生和修复会议同时举行，为遗传学、iPSC 疾病模型、干细胞治疗和表观遗传学方面的联合会议提供了绝佳的机会。