Chromatin and Epigenetics

染色质和表观遗传学

基本信息

批准号：
9106870
负责人：
DAVID L. WOODLAND
金额：
$ 0.4万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2016-11-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9106870
关键词：
Animal Model Attention Canada Chromatin Chromatin Fiber Chromatin Modeling Chromatin Structure Chromosome Structures Collaborations DNA Discipline Educational workshop Epigenetic Process Eukaryotic Cell Feedback Fostering Gene Expression Regulation Genetic Transcription Genomic approach Health Human Inherited International Knowledge Learning Literature Malignant Neoplasms Methodology Mission National Human Genome Research Institute Nucleosomes Outcome Process RNA Regulation Research Research Personnel Role Scientist Signal Transduction Stem cells The Cancer Genome Atlas Time Transcriptional Regulation Work Yang abstracting base clinical practice enzyme activity epigenetic drug epigenomics histone modification human disease inter-institutional meetings next generation novel posters public health relevance response stem cell biology stem cell fate symposium

Animal Model Attention Canada Chromatin Chromatin Fiber Chromatin Modeling Chromatin Structure Chromosome Structures Collaborations DNA Discipline Educational workshop Epigenetic Process Eukaryotic Cell Feedback Fostering Gene Expression Regulation Genetic Transcription Genomic approach Health Human Inherited International Knowledge Learning Literature Malignant Neoplasms Methodology Mission National Human Genome Research Institute Nucleosomes Outcome Process RNA Regulation Research Research Personnel Role Scientist Signal Transduction Stem cells The Cancer Genome Atlas Time Transcriptional Regulation Work Yang abstracting base clinical practice enzyme activity epigenetic drug epigenomics histone modification human disease inter-institutional meetings next generation novel posters public health relevance response stem cell biology stem cell fate symposium

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项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Chromatin and Epigenetics, organized by Luciano Di Croce and Yang Shi. The meeting will be held in Whistler, BC, Canada from March 20-24, 2016. The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Junior scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking. This meeting is relevant to the NCI mission because of its focus on chromatin and next generation epigenetic drugs. Indeed, The Cancer Genome Atlas, which is jointly administered by NCI and NHGRI, includes an epigenomics component.

描述（由适用提供）：请求支持由Luciano di Croce和Yang Shi组织的Keystone研讨会会议标题为“染色质和表观遗传学”。这次会议将于2016年3月20日至24日在加拿大卑诗省惠斯勒举行。真核细胞的DNA被组织成染色质纤维，其中核小体是基本的重复单元。因此，染色质是基因调节，干细胞脂肪测定和癌症等基本过程的核心。总的来说，这些主题传统上被分开的会议所涵盖。但是，最近的文献表明，这些各个学科之间的界限变得越来越清楚。这次会议将汇集研究染色质结构，表观遗传学，干细胞生物学和癌症的科学家。谈判将涵盖广泛的主题，包括染色体组织，远距离相互作用，染色质组装，干细胞调节/分化，基于RNA的机制和转录调控。已选择说话者从多种模型生物和实验方法中汲取的经验教训。初级科学家将能够通过从提交的摘要以及海报演示中选择的大量简短演讲来介绍他们的作品。在每个会议结束时，还将有足够的时间交换想法并讨论新的假设，以及非正式互动和网络的时间。这次会议与NCI任务有关，因为它专注于染色质和下一代表观遗传药物。实际上，由NCI和NHGRI共同管理的癌症基因组图集包括表观基因组学成分。