2023 Physiology, Biology and Pathology of Phosphate GRC

2023年磷酸盐GRC的生理学、生物学和病理学

• 批准号: 10608802
• 负责人: Sharon M Moe
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-10 至 2024-02-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608802
• 关键词: Advanced Development; Aging; Area; Attention; Basic Science; Biological Process; Biology; Cell physiology; Cells; Clinical Sciences; Collaborations; Communication; Complex; Discipline; Disease; Endocrine; Ensure; Environment; Equilibrium; Evaluation; Feedback; Fostering; Friends; Functional disorder; Future; Goals; Growth; Health; Homeostasis; Hour; Interdisciplinary Study; Intestines; Kidney; Kidney Diseases; Measurement; Mentors; Metabolism; Methods; Minerals; Modeling; Molecular; Oral; Organ; Parathyroid gland; Participant; Pathologic; Pathology; Pathway interactions; Physiology; Postdoctoral Fellow; Recording of previous events; Regulation; Research; Research Personnel; Science; Scientist; Senior Scientist; Signal Transduction; Social Interaction; Societies; System; Systems Biology; Translational Research; Woman; absorption; bone; career; career development; clinical care; design; disadvantaged background; falls; improved; innovation; inorganic phosphate; interdisciplinary collaboration; meetings; new therapeutic target; next generation; novel therapeutic intervention; nutrition; posters; pre-doctoral; programs; senior faculty; success; symposium; tool; translational pipeline; uptake

Project Summary/Abstract The 2023 Gordon Research Conference (GRC) “Physiology, Biology and Pathology of Phosphate” will provide cutting edge science and stimulate inter-disciplinary collaborations to facilitate a better understanding of the complexity of normal and pathologic phosphate regulation. This integration, or full understanding, or the systems biology that control this mineral is needed if we are to understand both normal physiology and regulation in different disease states. Investigators that study intestine, kidney, parathyroid glands and bone, each with both unique and common pathways for sensing, signaling, and responding to changes in phosphate concentrations will come together to share new discoveries. These scientists do not normally interact given the diversity of organs involved, and thus this GRC will provide a forum that facilitates scientific exchange among diverse scientists from around the world, working across the translational spectrum and from all career stages. The number of overall participants will be capped at 200 to ensure an environment conducive to friendly exchange, social interactions that facilitate collaborations, and conversations that propel the field forward. The program will have 25 talks organized into nine morning and evening sessions entitled 1) Overview of Phosphate in Health and Disease, 2) Organs Contributing to Phosphate Homeostasis and Endocrine Regulators, 3) Disorders of Phosphate Homeostasis, 4) Organ Crosstalk in the Regulation of Phosphate Balance, 5) Phosphate Sensing, Uptake, Signaling and Effects in cells, 6) Pathologic Effects of Phosphate on Cells, 7) Biology of Phosphate Containing Complexes 8) Measurements and Models, 9) The Intestinal Environment and Regulation of Phosphate Absorption. In each session, selected posters will be presented orally and there will be a facilitated discussion. Poster sessions will be held each day and purposely place investigators from different fields adjacent to each other to facilitate conversation and exchange of methods and ideas to build collaborations. The meeting will also have a “power hour” to focus on the challenges facing women in science, moderated by Co-Chairs and GRC staff. Additional small group opportunities that engage pre and post docs with senior faculty will be organized to provide career advice, identify potential mentors or sponsors, and facilitate collaborations. In summary, this inaugural GRC focusing on the cellular effects and regulation of phosphate homeostasis will facilitate cross-disciplinary collaborations and encourage trainees that the future of this field is exciting.

项目概要/摘要 2023年戈登研究会议（GRC）“磷酸盐的生理学、生物学和病理学”将提供 尖端科学和促进跨学科合作，以促进更好地理解 正常和病理性磷酸盐调节的复杂性，或充分理解，或系统。 如果我们要了解正常的生理学和调节，就需要控制这种矿物质的生物学 研究肠道、肾脏、甲状旁腺和骨骼的不同疾病状态。 用于传感、信号传导和响应磷酸盐浓度变化的独特且常见的途径 鉴于多样性，这些科学家通常不会互动。 因此，GRC 将提供一个论坛，促进不同领域之间的科​​学交流 来自世界各地的科学家，从事跨翻译领域和各个职业阶段的工作。 与会人数上限为200人，以确保有利于友好交流的环境， 促进合作的社交互动以及推动该领域向前发展的对话。 举办了 25 场讲座，分为 9 个早间和晚间会议，题为 1) 磷酸盐与健康概述 和疾病，2) 有助于磷酸盐稳态和内分泌调节的器官，3) 疾病 磷酸盐稳态，4) 磷酸盐平衡调节中的器官串扰，5) 磷酸盐传感， 细胞中的摄取、信号传导和作用，6) 磷酸盐对细胞的病理影响，7) 磷酸盐的生物学 含有复合物 8) 测量和模型，9) 肠道环境和调节 磷酸盐吸收 在每次会议中，将口头展示选定的海报，并将有一个便利的会议。 每天都会举行海报会议，并特意将来自不同领域的研究人员安排在相邻的位置。 互相促进对话和交流方法和想法，以建立合作。 还将有一个“权力时刻”，重点讨论女性在科学领域面临的挑战，由联合主席和 GRC 工作人员将提供与高级教师一起参与博士前和博士后的额外小组机会。 组织提供职业建议，寻找潜在的导师或赞助商，并促进合作。 总之，首次 GRC 重点关注磷酸盐稳态的细胞效应和调节 促进跨学科合作，并鼓励学员相信该领域的未来是令人兴奋的。