Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

基本信息

批准号：
9146632
负责人：
Ying Yuan
金额：
$ 18.93万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9146632
关键词：
Address Algorithms Animal Model Bioconductor Bioinformatics Biological Markers Biometry Biostatistics Core Cancer Center Cell Line Clinical Clinical Data Clinical Research Clinical Trials Code Computer software Data Data Analyses Databases Development Endometrial Endometrial Carcinoma Ensure Environment Epidemiology Experimental Designs Funding Gene Expression Profiling Genomics Gynecologic Human Resources Laboratories Laboratory Study Libraries Manuscripts Measures Methodology Methods Online Systems Pathology Phase Protein Array Proteomics Publications Publishing Quality Control Reporting Research Research Personnel Research Project Grants Resources Sample Size Services Staging Statistical Data Interpretation Statistical Methods System Testing Uterine Cancer Work Writing base career career development data management design electronic data experience genome analysis genomic data laboratory experiment meetings member next generation sequencing novel open source pre-clinical preclinical study programs research study sound tool web-accessible

项目摘要

Biostatistics and Bioinformatics Core SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core for the Endometrial Cancer SPORE program will support the Projects, and assist the other Cores, in the design and interpretation of clinical and preclinical experiments, and the acquisition and management of data. Core services will be critical for the clinical trials of the Projects, and their use of high-dimensional methodologies of gene expression profiling (GEP), next-generation sequencing (NGS) and Reverse Phase Protein Arrays (RPPAs). The Core will incorporate sound experimental design principles within each Project, specific to the scientific issues being addressed. Each Project will be provided with tailored analyses, accompanied by appropriate and sometimes novel biostatistical or bioinformatics methods. Core leaders will work with Project investigators to identify quantitative measures that can be used to test study hypotheses, including determining sample sizes to ensure sufficient power for the studies. The leaders of the Core will confer regularly with Project investigators to discuss the design and conduct of research projects, evaluate results of analyses, discuss potential new research initiatives and directions within the SPORE, and promote publication of findings. Interactions between the Core and Projects, as well as other integration, will be facilitated by a web-accessible database of relevant information generated by each Project, to be developed and maintained by the Core. The main objectives of the Biostatistics and Bioinformatics Core are to: 1. Provide biostatistics and bioinformatics expertise in the design and conduct of laboratory experiments and clinical trials arising from the research proposed in this application. 2. Provide biostatistics and bioinformatics analysis and interpretation of all data collected under the SPORE Projects, Career Enhancement Program Projects, Developmental Projects, and other Cores. 3. Collaborate and assist all project investigators with the publication of scientific results. 4. Develop and maintain a web-accessible, SPORE-specific database of relevant information for all Projects.

生物统计学和生物信息学核心摘要/摘要子宫内膜癌 SPORE 计划的生物统计学和生物信息学核心将支持项目并协助其他核心设计和解释临床和临床前实验，以及数据的获取和管理。核心服务对于项目的临床试验至关重要，以及他们对基因表达谱（GEP）的高维方法的使用，下一代测序 (NGS) 和反相蛋白阵列 (RPPA)。核心将包含声音实验每个项目中的设计原则，具体针对正在解决的科学问题。每个项目将提供量身定制的分析，并附有适当的、有时是新颖的生物统计或生物信息学方法。核心领导者将与项目调查人员合作，确定量化措施，可用于测试研究假设，包括确定样本大小以确保有足够的功效研究。核心领导者将定期与项目研究人员会面，讨论设计和开展研究项目，评估分析结果，讨论潜在的新研究计划以及 SPORE 内的指导，并促进研究结果的发表。核心和项目之间的相互作用，以及其他整合，将通过可通过网络访问的相关信息数据库来促进由每个项目，由核心开发和维护。生物统计学和生物信息学核心的主要目标是： 1. 提供设计和进行实验室实验的生物统计学和生物信息学专业知识由本申请中提出的研究产生的临床试验。 2. 对 SPORE 下收集的所有数据进行生物统计学和生物信息学分析和解释项目、职业提升计划项目、发展项目和其他核心。 3. 协作并协助所有项目研究者发表科学成果。 4. 开发和维护一个可通过网络访问的 SPORE 特定数据库，其中包含所有项目的相关信息。