Alcohol use, physical activity, and neurophysiological indicators of behavioral adaptability

饮酒、体力活动和行为适应性的神经生理学指标

• 批准号: 10609697
• 负责人: Andrew Antonio Ude
• 金额: $ 4.77万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609697
• 关键词: Acute; Address; Adult; Affect; Age; Alcohol abuse; Alcohol consumption; Alcohols; Back; Baroreflex; Behavior; Behavior Control; Behavior assessment; Behavioral; Biological; Blood Pressure; Brain; Cardiovascular system; Chronic; Communication; Cross-Sectional Studies; Development; Electrocardiogram; Electroencephalography; Event-Related Potentials; Exercise; Exhibits; Foundations; Future; Goals; Health; Health behavior; Heart; Heart Rate; Incentives; Individual; Individual Differences; Informal Social Control; Intervention; Interview; Intoxication; Knowledge; Longevity; Measures; Methodology; Monitor; Motivation; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Neurosciences; Parents; Patient Self-Report; Pattern; Periodicity; Persons; Physical activity; Process; Regulation; Research; Resources; Rest; Science; Stimulus; Strategic Planning; Testing; Training; United States National Institutes of Health; Withdrawal; actigraphy; addiction; alcohol cue; alcohol effect; alcohol measurement; alcohol research; alcohol use disorder; binge drinker; binge drinking; chronic alcohol ingestion; college; critical period; cue reactivity; design; drinking; emerging adult; emerging adulthood; experimental study; hazardous drinking; heart rate variability; high risk; high risk drinking; improved; incentive salience; neural; neuromechanism; neurophysiology; population health; programs; recruit; skills; social determinants; timeline; young adult

Project Summary and Abstract Health behaviors established during emerging adulthood often portend life-long behavior patterns. During this developmental stage, high-risk alcohol use behavior (binge-drinking) increases, while levels of physical activity begin to decrease. When considered individually, alcohol use and physical activity have marked and opposing influences on neurophysiological indicators of health and self-regulation. Acute and chronic alcohol negatively impact the cardiovascular system, resulting in decreased heart rate variability (HRV) and baroreflex sensitivity. High-risk drinking is also associated with greater incentive salience of alcohol cues, resulting in an enhanced P3 event-related potential to alcohol related stimuli (ACR-P3). Increased physical activity improves HRV, baroreflex sensitivity, and neural processes central to P3 amplitude reduction, although ACR-P3 has not been examined. Paradoxically, greater alcohol consumption consistently has been associated with more frequent physical activity across the adult lifespan. This raises the question of how the effects of this antagonistic clustering of co-occurring health-related behaviors accrue on the cardiovascular and neural processes that underlie their regulation. Further, a few recent studies suggest that this between-person association observed between alcohol use and physical activity may not reflect within-person drinking-activity relations, and most studies have relied on self-reports of physical activity. The goal of this study is to measure covariation in alcohol use and physical activity, assessed retrospectively, as well as objectively over a 7-10 day period to test the cumulative effects of drinking and activity behaviors on HRV, baroreflex sensitivity, and ACR-P3. The proposed research and training plan leverages the resources of a NIAAA-supported experiment (R21AA029604) examining whether a brief behavioral manipulation of the baroreflex loop can alter neural reactivity to alcohol cues in emerging adult binge drinkers. The proposed study will use simultaneously collected cardiovascular (ECG) and neural (EEG) measures recorded at rest and during an alcohol-cue reactivity paradigm from two sessions of the parent study, separated by 7-10 days. It will add on objective monitoring of physical activity during the intersession interval, combined with a time-line follow back interview of alcohol use and physical activity during the interval. Aim 1 is to examine covariation of alcohol use and physical activity behaviors assessed by self-report and actigraphy. Aim 2 is to examine the total effects of alcohol use and physical activity behaviors between sessions on HRV and baroreflex sensitivity (0.1Hz HRV). Aim 3 is to examine the cumulative effects of alcohol use and physical activity between sessions on incentive motivation towards alcohol cues, indicated by the ACR-P3. The proposed research and training plan are designed to address current gaps in understanding between drinking and activity behaviors to neurophysiological indicators of self-regulation, while providing the applicant with deeper knowledge and skills in alcohol research to support a developing research program on integrated cardiovascular and neural mechanisms in alcohol and co-occurring health behaviors.

项目概要和摘要 成年初期建立的健康行为通常预示着终生的行为模式。在此期间 发育阶段，高风险饮酒行为（酗酒）增加，而体力活动水平 开始减少。单独考虑时，饮酒和体力活动具有显着且相反的作用。 对健康和自我调节的神经生理指标的影响。急性和慢性酒精的负面影响 影响心血管系统，导致心率变异性 (HRV) 和压力反射敏感性降低。 高风险饮酒还与酒精暗示的更大激励显着性相关，从而导致 P3 增强 酒精相关刺激的事件相关电位（ACR-P3）。增加体力活动可改善 HRV、压力反射 尽管尚未检查 ACR-P3，但敏感性和对 P3 振幅降低至关重要的神经过程。 矛盾的是，更多的饮酒量始终与更频繁的体力活动有关 贯穿成人的一生。这就提出了这样一个问题：这种同时发生的对抗性集群的影响如何？ 与健康相关的行为会影响心血管和神经过程，而这些过程是其调节的基础。更远， 最近的一些研究表明，在饮酒和身体健康之间观察到这种人与人之间的关联 活动可能无法反映人体内饮酒与活动的关系，大多数研究都依赖于自我报告 体力活动。本研究的目的是测量饮酒和体力活动的协变，并评估 回顾性地、客观地在 7-10 天内测试饮酒和活动的累积影响 HRV、压力反射敏感性和 ACR-P3 的行为。拟议的研究和培训计划利用 NIAAA 支持的实验 (R21AA029604) 的资源，该实验检查是否存在短暂的行为操纵 压力反射环路的变化可以改变成年酗酒者对酒精信号的神经反应。拟议的 研究将使用同时收集的心血管 (ECG) 和神经 (EEG) 测量值（在休息和休息时记录） 在两次父母研究中的酒精提示反应范式中，间隔 7-10 天。它将 添加对休会期间身体活动的客观监测，并结合时间线跟踪 间隔期间饮酒和体力活动的回访。目标 1 是检查酒精的协变 通过自我报告和体动记录仪评估使用和身体活动行为。目标 2 是检查总体效果 会话之间的饮酒和体力活动行为对 HRV 和压力反射敏感性 (0.1Hz HRV) 的影响。 目标 3 是检查两次训练之间饮酒和体力活动对激励的累积影响 ACR-P3 表明了对酒精线索的动机。设计了拟议的研究和培训计划 解决当前饮酒和活动行为与神经生理学指标之间的理解差距 自我监管，同时为申请人提供更深入的酒精研究知识和技能，以支持 制定关于酒精和共发生的综合心血管和神经机制的研究计划 健康行为。