Exploration, conservation, & development of marine biodiversity in Fiji and the S

探索、保护、

基本信息

批准号：
9122517
负责人：
MARK E HAY
金额：
$ 97.72万
依托单位：
GEORGIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-29 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9122517
关键词：
Address Algae Analytical Chemistry Animals Antineoplastic Agents Aquaculture Area Awareness Bacteria Bacterial Infections Base Sequence Biodiversity Bioinformatics Biological Biological Assay Central Nervous System Diseases Chemicals Collaborations Communicable Diseases Communities Complex Country Coupled Data Detection Developing Countries Development Disease Drug resistance Drug resistance in tuberculosis Ecology Ecosystem Education Effectiveness Fiji Fishes Funding Future Genomics Goals Government Government Officials Habitats Health Hookworms Interdisciplinary Study International Invertebrates Investigation Island Larva Link Location Maintenance Malignant Neoplasms Marines Materials Testing Mediation Methodology Methods Microbe Microbiology Molecular Natural Product Drug Natural Products Natural Products Chemistry Nematoda Nerve Degeneration Organism Parasites Pharmaceutical Preparations Pharmacologic Substance Process Production Psychological Transfer Research Research Activity Resources Role Seaweed Services Solomon Islands Source Structure Surface Surveys System Taxon Techniques Technology Transfer Testing Therapeutic Tissues Transcend Transcription Factor AP-1 Transcription Factor AP-2 Alpha United States Universities Work analytical tool antimicrobial base bioactive natural products coral design drug development drug discovery genome sequencing guided inquiry improved innovation insight land use low and middle-income countries marine organism meetings microbial microbiome neglect neglected tropical diseases novel novel strategies novel therapeutics operation pathogen pre-clinical programs public health relevance rapid technique research clinical testing research study restoration screening small molecule targeted treatment technology training tool

项目摘要

DESCRIPTION (provided by applicant): This renewal International Cooperative Biodiversity Group (ICBG) application aims to discover and develop small molecule drug leads from cultured marine microbes and diverse coral reef organisms collected from Fiji and the Solomon Islands. Drug discovery efforts will focus on four major disease areas of relevance to the United States and low and middle income countries: infectious disease including tuberculosis and drug- resistant pathogens; neglected tropical diseases including hookworms and roundworms; cancer; and neurodegenerative and central nervous system disorders. Screening in these therapeutic areas will be performed in collaboration with two major pharmaceutical companies, two highly respected academic groups, and various testing centers and government resources that are available to facilitate drug discovery and development. The acquisition of source material for this program will be linked to biotic surveys, informed by ecological investigations addressing the chemical mediation of biotic interactions, and enriched using ecology- based strategies designed to maximize secondary metabolite production and detection. The program is heavily invested in microbial genomics, chemical ecology, the application of innovative cultivation methods and bioassays, sequence-based methodologies, and modern molecular and analytical tools as methods to improve the efficiency with which new natural products are discovered. The structures of all new compounds will be solved using modern techniques in analytical chemistry and produced in sufficient quantities for pre-clinical evaluation. The research activities of the four associate programs (AP1-4) are highly synergetic and emphasize training and technology transfer to the host country. The research maximizes the expertise of the program leaders to generate collaborative and highly interdisciplinary research objectives that transcend traditional natural product drug discovery paradigms. These activities are coordinated through the Central Operations Core and facilitated by the South Pacific Center for Drug Discovery and Conservation. The CDDC will work with marine ecologists to develop more effective strategies for reef conservation and to expand the Locally-Managed Marine Area (LMMA) program, which has proven to be a highly effective method to bring village-level awareness to the importance of conservation and the maintenance of healthy coral reefs.

描述（由申请人提供）：这种更新的国际合作生物多样性小组（ICBG）的应用旨在发现和开发从培养的海洋微生物和从斐济和所罗门群岛收集的各种珊瑚礁生物体中发现和开发小分子药物铅。药物发现工作将集中在与美国和低收入国家相关的四个主要疾病领域：传染病，包括结核病和耐药病原体；被忽视的热带疾病，包括钩虫和round虫；癌症;以及神经退行性和中枢神经系统疾病。在这些治疗领域进行筛查将与两家主要的制药公司合作进行，两个备受推崇的学术团体以及可用于促进药物发现和开发的各种测试中心和政府资源。为此获得原始资料程序将与生物调查有关，并通过针对生物相互作用的化学中介化的生态研究得知，并使用基于生态学的策略富含旨在最大化次级代谢物生产和检测的策略。该计划大量投资于微生物基因组学，化学生态学，创新培养方法和生物测定，基于序列的方法以及现代分子和分析工具作为提高发现新天然产品的效率的方法。所有新化合物的结构将使用分析化学中的现代技术来解决，并以足够数量的临床前评估产生。四个副计划（AP1-4）的研究活动具有高度的协同作用，并强调培训和技术转移到东道国。这项研究最大程度地提高了计划负责人的专业知识，以产生超越传统天然产品药物发现范式的协作和高度跨学科的研究目标。这些活动通过中央运营核心协调，并由南太平洋药物发现与保护中心促进。 CDDC将与海洋生态学家合作，制定更有效的珊瑚礁保护策略，并扩大本地管理的海洋地区（LMMA）计划，该计划被证明是将乡村级别的认识带入保护和维持健康珊瑚礁的重要方法。