2023 Cilia, Mucus and Mucociliary Interactions GRC & GRS

2023 纤毛、粘液和粘液纤毛相互作用 GRC

基本信息

批准号：
10601200
负责人：
BRIAN M BUTTON
金额：
$ 0.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10601200
关键词：
Address Adult Area Asthma Automobile Driving Biochemical Biochemistry Biological Biological Models Biology Biomedical Engineering Biophysics COVID-19 pandemic Cellular biology Child Chronic Bronchitis Chronic Disease Chronic Obstructive Pulmonary Disease Cilia Clinical Collaborations Cystic Fibrosis Data Development Developmental Biology Diagnosis Diagnostic Discipline Disease Education Elements Emerging Technologies Environment Epithelial Cells Etiology Faculty Female Fostering Foundations Functional disorder Genetic Genetic Diseases Genetic Research Genomics Glycoproteins Goals Growth Hair Image Infection Inhalation Italy Knowledge Leadership Link Lung diseases Mechanics Medicine Mentors Mentorship Methods Minority Mission Molecular Mucins Mucociliary Clearance Mucous body substance Oral Participant Pathologic Physiology Polymers Postdoctoral Fellow Primary Ciliary Dyskinesias Production Regulator Genes Research Research Personnel Respiratory System Respiratory Tract Diseases Scientist Senior Scientist Structure Surface Talents Technology Translational Research Underrepresented Minority United States National Institutes of Health Veins Woman Work airway epithelium burden of illness career cilium motility empowerment human disease idiopathic pulmonary fibrosis innovation knowledge integration lectures meetings minority scientist molecular scale multidisciplinary multiple omics nanoscale novel pathogen posters programs public health relevance research and development respiratory health stem success symposium translational scientist

项目摘要

PROJECT SUMMARY This application seeks support for a Gordon Research Conference (GRC) and corresponding Gordon Research Seminar (GRS) on Cilia, Mucus and Mucociliary Interactions from February 18-24, 2023 in Barga, Italy. This is a highly integrated and unique meeting that unites basic scientists, bioengineers, translational investigators, and clinicians who study the components and fundamentals of cilia and mucus biology, their interface as a mucociliary apparatus, and human diseases related mucociliary dysfunction. Mucociliary clearance (MCC) is essential for respiratory tract defense against inhaled pathogens. MCC dysfunction leads to infections and to complications in asthma, rhinosinusitus, chronic obstructive lung disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Advancing technologies have led to growing knowledge of the assembly and function of cilia, the production and secretion of mucin glycoproteins, and the cilia-mucus interactions required for MCC. These innovations stem from the on-going work of established teams and new entrants, including young investigators. Thus, an important element of this meeting is promoting trainees and young investigators and involving women and minorities in alignment with missions of the GRC and the NIH. This GRS/GRC meeting will lay foundations and provide new ideas for current and emerging leaders in the mucociliary biology. A cohesive program is proposed to enhance the interplay between specialized disciplines that seek to integrate knowledge and impact advances in biochemistry, biophysics, cell biology, development, genetics, and translational research of common respiratory tract diseases. To enhance the educational strength of the meeting, trainees will be invited to participate in a GRS, to present oral summaries of their posters during morning lecture blocks, and in some cases give 10 min talks during the GRC meeting. The GRS and GRC leadership teams have the shared goal of fostering an innovative, informative, and integrated forum for discussing novel research and current challenges in mucociliary biology. The conference will emphasize the following scientific themes: a) genetic and gene regulatory mechanisms of mucociliary components, b) structure and function of mucin glycoprotein polymers and motile cilia, c) secretion of mucins and mechanics of ciliary activity, d) the effects of mucociliary function and dysfunction on host physiology and pathophysiology, and e) the on-going application of cilia and mucus biology to develop promote respiratory health and reduce the burden of disease. With this approach, we seek to achieve three Specific Aims: 1) To disseminate, discuss, and integrate the latest, unpublished, cutting-edge data on cilia, mucus and mucociliary interactions in a forum of world experts and early career scientists; 2) to provide a platform that links fundamental scientific knowledge related to cilia, mucus, and mucociliary interactions to human disease and avenues for diagnosis and therapies; and 3) to facilitate and promote the involvement and advancement of underrepresented minorities, women, and trainees in the study of cilia, mucus and mucociliary interactions.

项目概要此申请寻求对戈登研究会议（GRC）和相应戈登研究的支持关于纤毛、粘液和粘膜纤毛相互作用的研讨会 (GRS) 将于 2023 年 2 月 18 日至 24 日在意大利巴尔加举行。这是一次高度综合且独特的会议，将基础科学家、生物工程师、转化研究人员和研究纤毛和粘液生物学的组成和基础的临床医生，它们的界面作为粘膜纤毛装置和人类疾病相关的粘膜纤毛功能障碍。粘液纤毛清除率 (MCC) 是对于呼吸道防御吸入病原体至关重要。 MCC 功能障碍会导致感染并哮喘、鼻窦炎、慢性阻塞性肺病 (COPD)、特发性肺纤维化的并发症（IPF）、囊性纤维化（CF）和原发性纤毛运动障碍（PCD）。技术的进步带来了不断增长的了解纤毛的组装和功能、粘蛋白糖蛋白的产生和分泌以及 MCC 所需的纤毛-粘液相互作用。这些创新源于现有团队的持续工作以及新进入者，包括年轻的研究人员。因此，本次会议的一个重要内容就是推动受训人员和年轻调查员的参与，并让妇女和少数族裔参与进来，以符合 GRC 的使命和美国国立卫生研究院。这次 GRS/GRC 会议将为现任和新兴领导人奠定基础并提供新想法在粘液纤毛生物学中。提出了一项有凝聚力的计划，以加强专业之间的相互作用寻求整合知识并影响生物化学、生物物理学、细胞生物学、常见呼吸道疾病的发生、遗传学和转化研究。为了增强会议的教育强度，学员将被邀请参加GRS，进行口头总结在上午的演讲时段展示他们的海报，有时还会在 GRC 会议期间进行 10 分钟的演讲。 GRS 和 GRC 领导团队的共同目标是培养创新、信息丰富和综合性的组织讨论粘液纤毛生物学的新颖研究和当前挑战的论坛。会议将强调以下科学主题：a) 粘膜纤毛的遗传和基因调控机制成分，b) 粘蛋白糖蛋白聚合物和运动纤毛的结构和功能，c) 粘蛋白的分泌和纤毛活动机制，d) 粘液纤毛功能和功能障碍对宿主生理的影响和病理生理学，以及 e) 纤毛和粘液生物学的持续应用，以促进呼吸系统健康并减轻疾病负担。通过这种方法，我们力求实现三个具体目标：1) 传播、讨论和整合有关纤毛、粘液和粘液纤毛的最新、未发表的前沿数据在世界专家和早期职业科学家论坛中的互动； 2）提供一个链接基础的平台与纤毛、粘液和粘液纤毛相互作用与人类疾病相关的科学知识以及治疗途径诊断和治疗； 3) 促进和促进代表性不足的人的参与和进步少数族裔、妇女和受训者参与纤毛、粘液和粘液纤毛相互作用的研究。