EXERCISE DELAYS DIABETIC HEART DISEASE BY REDUCING ADIPOSE-RELATED INFLAMMATION

运动通过减少脂肪相关炎症来延缓糖尿病心脏病

基本信息

批准号：
7615877
负责人：
Lisa Delores VanHoose
金额：
$ 2.81万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-04 至 2011-02-03
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7615877
关键词：
Address Adipocytes Adipose tissue Adult Aerobic Exercise African American Animal Model Attenuated Cardiac Cardiomyopathies Cardiovascular Diseases Cardiovascular system Cause of Death Cessation of life Characteristics Child Chronic Control Groups Coupled Development Diabetes Mellitus Disease Dyslipidemias Epidemic Equilibrium Evaluation Exercise Eye Functional disorder Gene Expression Health Heart Diseases Hispanic Americans Human Hyperglycemia Hyperlipidemia Hyperplasia Hypertrophy Incidence Indirect Calorimetry Infiltration Inflammation Inflammatory Institution Insulin Resistance Intake Integral Membrane Protein Integumentary system Interleukin-6 Intervention Left Ventricular Function Life Style Lipolysis Metabolic Metabolism Methods Microscopy Mission Modeling Molecular Monitor Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Study Overweight Pathology Performance Persons Population Prevention Process Prostate Proteins Rattus Recommendation Research Risk Factors Role Sampling Sensory Serum Skeletal Muscle Stroke Techniques Testing Time Training Tumor Necrosis Factor-alpha United States United States National Institutes of Health Very Light Exercise cytokine diabetes management diabetic diabetic rat early onset gastrointestinal heart disease risk hemodynamics inflammatory marker lipid biosynthesis lipoprotein lipase macrophage meetings programs research study sedentary sterol esterase

项目摘要

DESCRIPTION (provided by applicant): As obesity explodes in the United States, the incidence of type 2 diabetes escalates within many populations, particularly in African and Hispanic American groups. Type 2 diabetes presents with devastating complications of the cardiovascular, eye, gastrointestinal, sensory, and integumentary systems. Two out of three diabetic deaths are due to heart disease and stroke. The risk for heart disease is 2-4 times higher for persons with diabetes. The numbers will only grow as research shows earlier onset of diabetes and large increases in the number of obese persons. Obesity causes low-grade systemic inflammation which becomes the primary factor for cardiovascular disease. Several institutions and organizations have documented the benefits of aerobic exercise for adults and children in the management of diabetes. However, the majority of research has focused on skeletal muscle and insulin resistance. The purpose of the proposed study is to evaluate the impact of aerobic exercise on lessening diabetic cardiovascular effects through decreased adipose-related inflammation. The Zucker Diabetic Fatty rat, a model of type 2 diabetes, will be used to investigate our hypothesis. Evaluation of changes in the size, number, metabolism, and cytokines of adipose tissue in exercise and sedentary groups will allow for a greater understanding of the inflammatory process. The examination of six-transmembrane protein of prostate 2, STAMP 2, will provide evidence towards its role as a possible target in adipose-related inflammation. Finally, the demonstration of the positive effects of aerobic exercise on decreasing diabetic cardiac dysfunction will be shown through hemodynamic monitoring and serum analysis. The long-term objective is to provide strong support for the mission of the National Institute of Health in the prevention of Type 2 diabetes through educational programming, lifestyle recommendations, and possible pharmacological interventions. Relevance: Persons with type 2 diabetes present with a substantial increased risk for heart disease. The proposed research will evaluate the benefits of aerobic exercise on reducing inflammation in adipose tissue, possible regulators of adipose tissue, and the promotion of cardiovascular health in a type 2 diabetes animal model.

描述（由申请人提供）：随着肥胖症在美国的爆发，2型糖尿病的发生率在许多人群中升级，尤其是在非洲和西班牙裔美国人群体中。 2型糖尿病呈现出心血管，眼睛，胃肠道，感觉和外皮系统的毁灭性并发症。三分之二的糖尿病死亡是由于心脏病和中风引起的。糖尿病患者的心脏病风险高2-4倍。这些数字只会随着研究表明糖尿病的早期发作和肥胖人数的大量增加而增长。肥胖会引起低度的全身性炎症，这成为心血管疾病的主要因素。几个机构和组织已经记录了有氧运动对成人和儿童在糖尿病管理中的好处。但是，大多数研究都集中在骨骼肌和胰岛素抵抗上。拟议的研究的目的是评估有氧运动对减少脂肪相关炎症减少糖尿病心血管效应的影响。扎克糖尿病脂肪大鼠是一种2型糖尿病模型，将用于研究我们的假设。评估运动和久坐组中脂肪组织的大小，数量，代谢和细胞因子的变化将使人们对炎症过程有更多了解。对前列腺2，邮票2的六跨膜蛋白的检查将提供证据，以作为其作为脂肪相关炎症的可能目标的作用。最后，有氧运动对减少糖尿病心脏功能障碍的积极作用的证明将通过血液动力学监测和血清分析显示。长期目标是通过教育计划，生活方式建议和可能的药理干预措施，为美国卫生研究院预防2型糖尿病的使命提供大力支持。相关性：患有2型糖尿病患者患心脏病的风险大大增加。拟议的研究将评估有氧运动对减少脂肪组织炎症的益处，脂肪组织的可能调节剂以及促进2型糖尿病动物模型中心血管健康的促进。