Behavioral and Neural Outcomes of a New Executive Function Treatment for Transition-Age Youth with ASD

新的执行功能治疗对患有自闭症谱系障碍的过渡年龄青少年的行为和神经结果

基本信息

批准号：
9164397
负责人：
Cara Pugliese
金额：
$ 14.81万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-11 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9164397
关键词：
Accounting Adult Affect Aftercare Age Anterior Anxiety Attention deficit hyperactivity disorder Autistic Disorder Award Behavior Behavioral Benchmarking Binding Biological Markers Biological Neural Networks Brain Caring Child Clinic Cognitive Collaborations Communities Control Groups Data Development Developmental Disabilities Disease Effectiveness Evidence based treatment Executive Dysfunction Expert Opinion Failure Feedback Fellowship Foundations Functional Magnetic Resonance Imaging Future Goals High School Student Home environment Individual Intellectual functioning disability Intervention Intervention Studies Investigation K-Series Research Career Programs Laboratories Learning Skill Life Link Manuals Measurement Measures Mental Retardation and Developmental Disabilities Research Centers Mental disorders Mentors Mentorship Methodology Methods Modeling National Institute of Mental Health Outcome Outcome Measure Outcomes Research Participant Phenotype Pilot Projects Population Prefrontal Cortex Problem Solving Problem behavior Process Research Research Domain Criteria Research Personnel Rest Risk Running Schools Science Solid Structure Students Subgroup Symptoms Testing Training Treatment outcome United States Work Youth aged attentional control autism spectrum disorder base career causal model cingulate cortex college community intervention cost design developmental disease effectiveness trial elementary school executive function experience flexibility follow-up health care availability high school implementation science improved innovation insight multidisciplinary neural correlate neuroimaging neuropsychological novel patient oriented personalized intervention post intervention productivity loss psychologic relating to nervous system segregation skills skills training social skills therapy development trial comparing university student

项目摘要

PROJECT SUMMARY Autism Spectrum Disorders (ASD) affect 1 in 88 children in the United States. Individuals without intellectual disabilities comprise the fastest-growing subgroup of ASD and account for two-thirds of the total population. Impaired executive functions (EF) occur as a result of abnormal prefrontal cortex function and are related to poor adult outcome. EF problems are pivotal targets for intervention because they are common, linked to independence, and responsive to treatment. The proposed study will test the effectiveness of a school-based cognitive behavioral EF intervention, called Flexible Futures (FF), for college-bound youth with ASD and evaluate the neural correlates of treatment outcome. FF is a targeted, phenotype-specific intervention focused on the domains of EF that are most impaired in ASD – flexibility and planning skills. This K23 Mentored Patient-Oriented Career Development Award application is to request support for the candidate's development as an independent investigator specializing in the development and implementation of innovative interventions personalized for specific cognitive profiles that are transportable for mass usage in school-settings. This K23 Mentored Patient-Oriented Career Development Award will provide focused research experience and theoretical training in the development of evidence-based treatments that support transition to adulthood in ASD. The award will also provide training and experience in the investigation of neural predictors and correlates of treatment outcome using neuroimaging methods. In accordance with these goals, the training aims of this proposal are to: 1) develop an understanding of causal models of developmental disabilities and expertise in measurement of key outcomes at the behavioral, cognitive, and neural levels; 2) acquire expertise in the development of treatments for transition-age youth within the school setting; and 3) gain competencies in the methodology, design, and implementation science of pragmatic community-partnered effectiveness trials. The proposed research aims for this project are to: 1) refine the treatment manual for Flexible Futures and test its acceptability, feasibility, and effectiveness in a school setting, 2) identify neural correlates of treatment change using fMRI, and 3) identify biomarkers of EF outcomes at the behavioral, cognitive, and neural level. The treatment manual will be iteratively refined with input from experts in the field of ASD research and tested for effectiveness against a social skills intervention within an educational setting. Flexible Futures is anticipated to result in changes at the behavioral, cognitive, and neural level. Specifically, it is hypothesized that participants in Flexible Futures will demonstrate greater gains in flexibility and planning compared to those in social skills treatment. Significant changes in behavior and brain activity as a result of Flexible Futures could have profound implications for the development and refinement of psychological treatments for ASD.

项目摘要自闭症谱系障碍（ASD）影响了美国88名儿童中的1个。没有智力的人残疾包括ASD增长最快的亚组，占总人口的三分之二。行政功能受损（EF）是由于前额叶皮层功能异常而发生的，并且与成人不良结果。 EF问题是干预的关键目标，因为它们很常见，与独立，对治疗的反应。拟议的研究将测试基于学校的有效性与ASD和评估治疗结果的神经相关性。 FF是针对特定表型的针对性的干预措施在ASD中最受损害的EF领域 - 灵活性和计划技能。这个K23指导了面向患者的职业发展奖的申请是为候选人的发展提供支持作为专门研究创新干预措施开发和实施的独立研究者个性化的特定认知概况，可以在学校安装中进行大规模使用。这项K23指导的以患者为导向的职业发展奖将提供重点的研究经验和在发展基于证据的治疗的理论培训，以支持过渡到成年 ASD。该奖项还将在调查神经预测因子和使用神经影像学方法的治疗结果相关。根据这些目标，培训该提案的目的是：1）对发育障碍的因果模型建立了解在行为，认知和神经水平的关键结果测量方面的专业知识； 2）获得专业知识在学校环境中的过渡年龄青年治疗方面； 3）获得能力实用社区有效性试验的方法，设计和实施科学。拟议的研究目的是：1）完善灵活未来的治疗手册并进行测试它在学校环境中的可接受性，可行性和有效性，2）确定治疗的神经相关性使用fMRI和3）在行为，认知和神经层面上确定EF结局的生物标志物。该治疗手册将通过ASD研究领域的专家的意见进行迭代完善并进行了测试在教育环境中反对社交技能干预的有效性。预计灵活的期货将会在行为，认知和神经水平上导致变化。具体来说，假设与之相比社交技能治疗。由于灵活的未来，行为和大脑活动的重大变化可能对ASD的心理疗法的发展和完善具有深远的影响。