Prostate Cancer Assessment Via Integrated 3D ARFI Elasticity Imaging and Multi-Parametric MRI

通过集成 3D ARFI 弹性成像和多参数 MRI 进行前列腺癌评估

• 批准号: 8905274
• 负责人: Matthew McCormick
• 金额: $ 15万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8905274
• 关键词: Acoustics; American; Award; Biological Markers; Biopsy; Biopsy Specimen; Businesses; Cancer Etiology; Cessation of life; Collection; Computer software; Consult; Data; Data Analyses; Data Collection; Data Set; Detection; Development; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Elasticity; Funding; Goals; Hemorrhage; Heterogeneity; Histology; Image; Imaging Techniques; Impotence; Incontinence; Indolent; Infection; Lead; Machine Learning; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Measures; Methods; Modeling; Operative Surgical Procedures; Organ; PSA level; Phase; Probability; Radiation; Radical Prostatectomy; Resolution; Retrospective Studies; Risk; Sampling; Second Primary Cancers; System; Systems Development; Testing; Time; Tissues; Ultrasonics; Ultrasonography; United States; United States National Institutes of Health; Universities; Urinary Incontinence; Work; cancer diagnosis; commercialization; design; high risk; image guided; image registration; imaging modality; imaging system; innovation; men; novel; open source; phase 2 study; public health relevance; spectroscopic imaging; standard of care; success; treatment planning; tumor

 DESCRIPTION (provided by applicant): Prostate cancer (PCA) is the most common non-skin cancer and the second leading cause of cancer death in American men, with over 186,000 new cases diagnosed and over 28,000 PCA deaths annually in the United States. Ultrasound-guided biopsy is the standard of care for confirming cancer, typically following elevated PSA levels; however, it has been estimated that up to 20% of men require three or more biopsy sessions for diagnosis, and biopsies have a high risk of hemorrhage and infection. Furthermore, biopsies are not sufficient for tumor delineation or characterization because they sparsely sample the entire organ. Regretfully, the deficiencies of biopsy have lead to over-treatment of indolent disease with radical prostatectomies, a drastic treatment that has significant risks of infection, hemorrhage, urinary incontinence, and impotence. We are the inventors of Acoustic Radiation Force Impulse (ARFI) imaging and the inventors of Shear Wave Elasticity Imaging (SWEI) methods. We have now combined those methods into ARFI-SWEI imaging sequences that define a new and novel multi-parametric ultrasonic elasticity imaging system. This multi-parametric elasticity imaging approach provides an absolute, quantitative measure of tissue stiffness, at high resolution, in 3D, using ultrasound. We hypothesize that synergistic diagnostic information from B-mode, ARFI-SWEI and multi-parametric MRI (mpMRI, e.g., diffusion weighted imaging and MR spectroscopy imaging) enable (a) the sensitive and specific diagnosis of PCA and (b) the accurate delineation of PCA margins. We propose retrospective studies on existing 3D B-mode, ARFI-SWEI and mpMRI imaging datasets to test this hypothesis. 1

 描述（由申请人提供）：前列腺癌 (PCA) 是最常见的非皮肤癌，也是美国男性癌症死亡的第二大原因，美国每年诊断出超过 186,000 例新病例，并有超过 28,000 例 PCA 死亡。 - 引导活检是确诊癌症的标准治疗方法，通常是在 PSA 水平升高后进行，但据估计，多达 20% 的男性需要进行 3 次或以上的活检来诊断癌症；此外，活检不足以描述肿瘤或表征，因为活检对整个器官的取样很少，遗憾的是，活检的缺陷导致了根治性前列腺切除术对惰性疾病的过度治疗。 ，一种具有感染、出血、尿失禁和阳痿风险的剧烈治疗。我们是声辐射力的发明者。脉冲 (ARFI) 成像和剪切波弹性成像 (SWEI) 方法的发明者现在将这些方法组合到 ARFI-SWEI 成像序列中，定义了一种新颖的多参数超声弹性成像系统。我们利用超声波以高分辨率、3D 方式提供组织硬度的绝对定量测量。 来自 B 模式、ARFI-SWEI 和多参数 MRI（mpMRI，例如弥散加权成像和 MR 光谱成像）的信息能够实现 (a) PCA 的灵敏和特异性诊断以及 (b) PCA 边缘的准确描绘。对现有 3D B 模式、ARFI-SWEI 和 mpMRI 成像数据集进行回顾性提案研究来检验这一假设 1。