Do experiences of early adversity differentially contribute to dynamic fluctuations in dysregulated drinking through their effects on behavioral and emotional dysregulation?

早期逆境经历是否会通过对行为和情绪失调的影响而导致饮酒失调的动态波动？

• 批准号: 10603949
• 负责人: Michele R. Smith
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2024-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10603949
• 关键词: Adolescent and Young Adult; Adverse event; Affect; Age; Alcohol consumption; Alcohols; Behavior; Behavioral; Cessation of life; Development; Ecological momentary assessment; Emotional; Emotions; Ethics; Etiology; Event; Exhibits; Fellowship; Funding; Glean; Health; Health Personnel; Heterogeneity; Individual; Individual Differences; Informal Social Control; Intervention; Lead; Life; Link; Literature; Maintenance; Measures; Mediating; Mediator of activation protein; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Participant; Patient Self-Report; Persons; Prevention; Process; Reflex action; Regulation; Reporting; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Shapes; Strategic Planning; Substance Use Disorder; Testing; The Sun; Time; Training; Variant; alcohol misuse; alcohol misuse prevention; alcohol related problem; alcohol use disorder; base; binge drinking; career development; childhood adversity; deprivation; design; drinking; drinking behavior; early experience; early life adversity; emotion dysregulation; emotion regulation; experience; high risk; improved; innovation; method development; morphogens; novel; pre-doctoral; prospective; recruit; rumination; social; stressor; substance use; theories; trait; young adult

ABSTRACT Up to one-third of young adults report dysregulated drinking behavior each month and alcohol misuse by young adults results in over 1,500 deaths per year. Thus, it is crucial to understand etiologic factors that contribute to the development of dysregulated alcohol use. Most young adults have experienced childhood adversity—and experiences of childhood adversity may account for nearly 1/3 of adolescent and young adult substance use disorders. Inconsistent findings for the relation between adversity and dysregulated drinking may be clarified by examining unique adverse experiences of threat and deprivation. As both potential consequences of adversity and strong predictors of dysregulated drinking, negative urgency and emotion dysregulation may be potential mechanisms for this association. Thus, further exploration into the daily dynamics of these factors is warranted. This study proposes to investigate how experiences of early adversity contribute to dynamic fluctuations in dysregulated drinking through their effects on behavioral and emotional dysregulation. The study will use an ecological momentary assessment (EMA) design in order to characterize how experiences of threat and deprivation contribute to daily processes that may lead to daily dysregulated drinking. Young adults ages 18-22 (N=500) will be recruited for intensive longitudinal assessment of substance use and affect. Participants will provide daily reports of their negative urgency, emotional volatility, reflexive emotion regulation, and daily alcohol intentions and use. Findings from this study could inform prevention efforts by identifying individual difference factors that contribute to dysregulated drinking at a daily level, as well as possible targets for intervention. The proposed study represents innovation over prior research because there has not yet been a study that synthesizes threat and deprivation with fluctuations in behavioral and emotion dysregulation and their links to dysregulated drinking at a daily level. This study is aligned with the strategic plan of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), as it has possible implications for understanding the development and improving prevention of alcohol misuse during the high- risk developmental period of young adulthood. The funding of this project will provide substantial training to an emerging predoctoral researcher in ethics, research methodology, advanced quantitative methods, and career development. Overall, this project will illuminate processes by which early adversity contributes to behavioral and emotional dysregulation, and how these processes relate to dysregulated drinking.

抽象的 多达三分之一的年轻人每月报告饮酒行为失调和酗酒 每年有超过 1,500 名年轻人死亡，因此了解其病因至关重要。 导致酒精使用失调的发展 大多数年轻人都经历过童年。 逆境——童年逆境经历可能占青少年和青年人的近 1/3 物质使用障碍。逆境与饮酒失调之间的关系的研究结果不一致。 可以通过检查威胁和剥夺的独特不良经历来澄清。 逆境的后果以及饮酒失调、消极紧迫感和情绪的强烈预测因素 调节失调可能是这种关联的潜在机制，因此，需要进一步探索日常情况。 这些因素的动态变化是必要的，这项研究旨在调查早期逆境的经历。 通过对行为和情绪的影响，导致饮酒失调的动态波动 该研究将使用生态瞬时评估（EMA）设计来表征。 威胁和剥夺的经历如何影响可能导致日常失调的日常过程 将招募 18-22 岁的年轻人（N = 500）进行物质的强化纵向评估。 参与者将提供关于他们的负面紧迫性、情绪波动、反射性的每日报告。 这项研究的结果可以为预防提供信息。 通过识别导致日常饮酒失调的个体差异因素，以及 拟议的研究代表了先前研究的创新，因为 目前还没有一项研究将威胁和剥夺与行为和行为的波动综合起来。 情绪失调及其与日常饮酒失调的联系这项研究与 国家酒精滥用和酒精中毒研究所 (NIAAA) 的战略计划，因为它有可能 对理解高风险时期滥用酒精的发展和改进预防的影响 该项目的资金将为青年期的风险发展期提供大量培训。 伦理学、研究方法、高级定量方法和职业领域的新兴博士前研究员 总体而言，该项目将阐明早期逆境促进行为的过程。 和情绪失调，以及这些过程与饮酒失调有何关系。