ENDOMETRIOSIS IN RHESUS MACAQUES

恒河猴子宫内膜异位症

• 批准号: 7958748
• 负责人: Stephen B. Kennedy
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958748
• 关键词: Affect; Age; Aging; Animal Model; Animals; Archives; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA; Environmental Risk Factor; Evaluation; Female; Fresh Tissue; Funding; Genetic Predisposition to Disease; Grant; Institution; Location; Macaca mulatta; Menstrual cycle; Mothers; Nuclear Family; Online Systems; Prevalence; Primates; Recurrence; Reporting; Research; Research Personnel; Resources; Risk; Services; Siblings; Source; Surveys; Tissue Sample; United States National Institutes of Health; Wisconsin; endometriosis; genetic pedigree; genome wide association study; nonhuman primate; segregation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate the prevalence and familial aggregation of endometriosis in rhesus macaques. Endometriosis occurs in several non-human primate species that have menstrual cycles. Between 1978 and 2002, we identified 144 rhesus macaques with endometriosis. We established a large multigenerational pedigree and nine nuclear families comprising 1,602 females. Prevalence of endometriosis increased with age. Familial aggregation of endometriosis was strongly suggested by a significantly higher average kinship coefficient among affected animals compared with those unaffected. We saw a higher recurrence risk for full siblings when compared to maternal half siblings and paternal half sibs. The segregation ratio among affected mothers was not significantly higher compared with unaffected mothers. The results support familial aggregation of endometriosis in rhesus macaques and indicate that this is a promising animal model for investigating the mode of inheritance, the location of potential genetic susceptibility loci and the influence of environmental factors. Evaluation of pedigree and genetic information is continuing. In the current report period, we isolated DNA from archived and fresh tissue samples for a genome-wide association study. The project is currently expanding to include additional clinical collaborators through our CTSA (see SPID 0447) and a web-based survey of the prevalence of endometrisosis in the colonies of the other NPRCs. This research used WNPRC Animal Services and Aging Resources. Funded by a supplement to RR000167.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：调查恒河猴子宫内膜异位症的患病率和家族聚集性。 子宫内膜异位症发生在几种有月经周期的非人类灵长类动物身上。 1978 年至 2002 年间，我们发现 144 只恒河猴患有子宫内膜异位症。我们建立了一个庞大的多代谱系和 9 个核心家庭，其中包括 1,602 名女性。子宫内膜异位症的患病率随着年龄的增长而增加。与未受影响的动物相比，受影响动物的平均亲属关系系数显着较高，强烈表明子宫内膜异位症具有家族聚集性。我们发现，与同母异父的兄弟姐妹和同父异母的兄弟姐妹相比，同父异母的兄弟姐妹的复发风险更高。与未受影响的母亲相比，受影响母亲的隔离率并没有显着升高。结果支持恒河猴子宫内膜异位症的家族聚集性，并表明这是研究遗传模式、潜在遗传易感位点的位置和环境因素影响的有前途的动物模型。谱系和遗传信息的评估仍在继续。在本报告期内，我们从存档和新鲜组织样本中分离出 DNA，用于全基因组关联研究。 该项目目前正在扩大范围，通过我们的 CTSA（参见 SPID 0447）以及对其他 NPRC 群体子宫内膜异位症患病率的网络调查来纳入更多临床合作者。 这项研究使用了 WNPRC 动物服务和老龄化资源。由 RR000167 的补充资金资助。