Real-time Asthma and Air Pollution Project (Asthma APP)

实时哮喘与空气污染项目（哮喘APP）

• 批准号: 9077039
• 负责人: FRANK D. GILLILAND
• 金额: $ 214.69万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9077039
• 关键词: 12 year old; Accounting; Acute; Address; Adherence; Air Pollutants; Air Pollution; Asthma; Biomedical Research; Bronchitis; California; Caregivers; Caring; Cations; Cessation of life; Child; Child health care; Childhood; Childhood Asthma; Chronic; Chronic Disease; Clinic; Clinical; Clinical Management; Communities; Coughing; Data; Development; Emergency department visit; Ensure; Environment; Etiology; Evaluation; Event; Exposure to; Family; Feedback; Future; Goals; Health; Hospitalization; Individual; Indoor environment; Intervention; Longitudinal Studies; Los Angeles; Measurement; Measures; Medical; Morbidity - disease rate; Neighborhoods; Outcome; Ozone; Participant; Particulate Matter; Patients; Pattern; Performance; Pharmaceutical Preparations; Physicians; Physiological; Play; Pollen; Pollution; Prevention; Preventive Intervention; Process; Production; Protocols documentation; Psychosocial Factor; Public Health; Quality of life; Recommendation; Recording of previous events; Recruitment Activity; Research Personnel; Risk; Scientific Advances and Accomplishments; Self Management; Sleep; Societies; Stress; Symptoms; System; Testing; Time; Validity and Reliability; abstracting; ambient air pollution; asthmatic patient; base; cost; economic cost; improved; information display; mHealth; meetings; performance tests; personalized intervention; personalized medicine; predictive modeling; prototype; psychosocial; sensor; trafficking; usability

PROJECT 3 ABSTRACT (PROJECT DESCRIPTION) Asthma exacerbations lasting for weeks occur in 25-50% of children with asthma each year in Southern Califor- nia. Remarkably, ozone and particulate matter (PM) may account for as much as 70% of bronchitis-related ex- acerbations in the polluted communities studied in the landmark Children’s Health Study (CHS). Given the clinical and public health burden from asthma exacerbations, there is a clear need for improved prevention and clinical management approaches. The Los Angeles PRISMS Center will develop a system to advance the scientific understanding of asthma symptoms and exacerbations as well as deliver timely, personalized interventions and treatments to support self-management activities, promote adherence, and provide active feedback to patients, caregivers, clinicians, and researchers. In this U54 application, we propose to develop and test an integrated asthma management platform, the Bio- medical REAl-Time Health Evaluation for Pediatric Asthma (BREATHE). The broad objectives of Project 3 are to develop, assess performance, and test field protocols for the integrative BREATHE platform; to improve sci- entific understanding of asthma exacerbations; and to develop risk prediction models using real-time data on determinates of exacerbations. To meet these objectives, we propose the following specific aims for this appli- cation: 1) to evaluate field performance of the BREATHE platform in key microenvironments including accuracy and precision of highly resolved spatial and temporal data for exposure assessment, reliability and validity of asthma outcomes and psychosocial variables (e.g., stress); 2) to develop and test field protocols for use of BREATHE in longitudinal studies of 8-12 year old children with asthma, including potential PRISMS U01 sensors; 3) to assess usability of BREATHE for children with asthma and their caregivers, for clinicians, and for research- ers including iterative refinement of protocols and the user interfaces; 4) to increase scientific understanding of the contextual real-time determinants of asthma exacerbations; and 5) to enhance a risk prediction model by incorporating real-time contextual data and analytics to provide actionable information for personalized self- management and prevention of exacerbations among children with asthma. The participants for Project 3 will be recruited from the UCLA Pediatric Asthma Clinic. Efforts in Project 3 are thus closely coordinated with the tech- nical developments in Projects 1 & 2 to ensure a usable end-to-end platform. Our anticipated outcome is a well- characterized and operational prototype demonstrating BREATHE, with great potential for supporting PRISMS and future pediatric biomedical research.

项目 3 摘要（项目描述） 在南加州，每年 25-50% 的哮喘儿童会出现持续数周的哮喘恶化。 值得注意的是，臭氧和颗粒物 (PM) 可能占支气管炎相关病例的 70%。 具有里程碑意义的儿童健康研究（CHS）研究了受污染社区的恶化情况。 和哮喘恶化带来的公共卫生负担，显然需要改进预防和临床 洛杉矶 PRISMS 中心将开发一个系统来推进科学发展。 了解哮喘症状和恶化情况，并提供及时、个性化的干预措施 支持自我管理活动、促进依从性并向患者提供积极反馈的治疗， 护理人员、居民和研究人员。 在此 U54 应用中，我们建议开发和测试集成哮喘管理平台 Bio- 儿童哮喘医学实时健康评估 (BREATHE) 项目 3 的主要目标是。 开发、评估性能并测试综合 BREATHE 平台的现场协议，以提高科学性； 对哮喘急性发作的深入了解；并利用实时数据开发风险预测模型 为了实现这些目标，我们为此应用提出以下具体目标。 阳离子：1) 评估 BREATHE 平台在关键微环境中的现场性能，包括准确性 用于暴露评估的高分辨率空间和时间数据的精度、可靠性和有效性 哮喘结果和心理社会变量（例如压力）；2) 制定和测试使用的现场方案 BREATHE 对 8-12 岁哮喘儿童的纵向研究，包括潜在的 PRISMS U01 传感器； 3) 评估 BREATHE 对哮喘儿童及其护理人员、教区居民和研究的可用性 - 包括对协议和用户界面的迭代细化；4) 增加对技术的科学理解； 哮喘恶化的实时决定因素；5) 通过以下方式增强风险预测模型： 结合实时上下文数据和分析，为个性化自我管理提供可操作的信息 项目 3 的参与者将是哮喘儿童病情恶化的管理和预防。 因此，项目 3 中的工作人员是从加州大学洛杉矶分校儿科哮喘诊所招募的，并与技术部门密切协调。 项目 1 和 2 中的正常开发确保了可用的端到端平台，我们的预期结果是一个良好的结果。 具有特色且可操作的原型，展示了 BREATHE，具有支持 PRISMS 的巨大潜力 以及未来的儿科生物医学研究。