Genomic Sciences Shared Resource

基因组科学共享资源

• 批准号: 10263979
• 负责人: SIMON Alexander MALLAL
• 金额: $ 36.01万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263979
• 关键词: Automation; Bioinformatics; Biological; Biological Assay; Cancer Center; Cancer Center Support Grant; Chromium; Classification; Communities; DNA; DNA sequencing; Data; Data Analyses; Effectiveness; Ensure; Experimental Designs; Formalin; Gene Expression; Genome; Genomic approach; Genomics; Genotype; Goals; Improve Access; Individual; Informatics; Laboratories; Libraries; Manuals; Mentors; Mentorship; Methods; Mission; Modernization; NCI Center for Cancer Research; Nucleic Acids; Paraffin Embedding; Performance; Phase; Play; Preparation; Process; Quality Control; RNA; Reproducibility; Reproducibility of Results; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Sampling; Science; Services; Somatic Mutation; Students; Technology; Tennessee; Time; Tissue Embedding; Training; Translating; Universities; Variant; Vision; Visualization; Work; biobank; computerized data processing; cost; data integrity; data management; data quality; design; experimental study; flexibility; genome sciences; genomic data; innovation; medical schools; member; nanopore; new technology; next generation sequencing; novel strategies; programs; responsible research conduct; sample collection; single cell sequencing; single cell technology; tool; transcriptome; transcriptome sequencing; whole genome

CORE 009 – GENOMIC SCIENCES SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The mission of the Genomic Sciences Shared Resource (GSSR) is to bring new and powerful genomics approaches to the Vanderbilt-Ingram Cancer Center (VICC) research community, inclusive of our VICC members and partners at Meharry Medical College, Tennessee State University, and other NCI centers. The vision of the GSSR is to rapidly translate the most powerful modern and enabling genomics technologies to practice and make these accessible to investigators. The GSSR seeks to maximize responsiveness to unmet scientific needs and partner with VICC investigators to develop and operationalize new processes, platforms, applications, assays and dry lab pipelines. To support investigators with their important work, the GSSR offers high level scientific concierge support. This includes advice on appropriate technology, sample collection, processing and extraction, biobanking and storage, and quality assessment. The GSSR offers project management and study design to protect sample and data integrity, data management and analysis. The GSSR seeks continuous improvement in quality, cost, scalability, and turn-around time, as well as an increase in the range of assays/applications and sample types across both wet and dry laboratory phases. GSSR has found that the need for genomic data analysis is increasing rapidly for many VICC investigators. Thus, over the next iteration of the CCSG, the shared resource plans to increase bioinformatic support for users, including the processing of data to deliver intermediate results (i.e. count table for RNAseq, variant calls for DNAseq, etc.) as well as provide tools for analysis and visualization with ongoing high-level expertise provided in the GSSR. Importantly, the GSSR supports researchers in the design of rigorous experimental approaches that are transparent and reproducible. The GSSR accomplishes these goals through training, informal mentorship and service provided by the core. The GSSR staff are particularly well suited to facilitating good experimental design and validated methods, providing authentication services for key biological resources and in defining and establishing rigorous methods for acquiring and analyzing genomic datasets.

核心 009 – 基因组科学共享资源 项目概要/摘要 基因组科学共享资源 (GSSR) 的使命是带来新的、强大的基因组学 与范德比尔特-英格拉姆癌症中心 (VICC) 研究社区（包括我们的 VICC 成员）的联系方式 以及梅哈里医学院、田纳西州立大学和其他 NCI 中心的合作伙伴。 GSSR 旨在快速将最强大的现代基因组学技术转化为实践和应用 GSSR 力求最大限度地响应未满足的科学需求。 并与 VICC 研究人员合作开发和实施新流程、平台、应用程序， 为了支持研究人员的重要工作，GSSR 提供​​高水平的服务。 科学礼宾支持包括有关适当技术、样品采集、处理和的建议。 GSSR 提供​​项目管理和研究。 GSSR 旨在保护样本和数据完整性、数据管理和分析。 质量、成本、可扩展性和周转时间的改进，以及范围的增加 GSSR 发现，湿法和干法实验室阶段的测定/应用和样品类型。 因此，在下一次迭代中，许多 VICC 研究人员对基因组数据分析的需求正在迅速增加。 CCSG 的共享资源计划旨在增加对用户的生物信息支持，包括处理 提供中间结果的数据（即 RNAseq 的计数表、DNAseq 的变异调用等）并提供 GSSR 提供​​了持续的高水平专业知识的分析和可视化工具。 GSSR 支持研究人员设计严格的实验方法，这些方法是透明的、 GSSR 通过提供培训、非正式指导和服务来实现这些目标。 GSSR 工作人员特别适合促进良好的实验设计和验证。 方法，为关键生物资源提供认证服务，并定义和建立严格的 获取和分析基因组数据集的方法。