MCRC for Rheumatic Diseases in African Americans

非裔美国人风湿病 MCRC

基本信息

批准号：
9133270
负责人：
Gary S Gilkeson
金额：
$ 115.83万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9133270
关键词：
Address Affect African American Autoimmune Process Biological Biometry Clinical Clinical Research Collaborations Communities Connective Tissue Diseases Consultations Coupled Development Development Plans Diagnosis Disease Disease Progression Education Epigenetic Process Family Fostering Funding Future General Population Genetic Genetic study Goals Government Agencies Health Health Personnel Health Professional Home environment Individual Institution Interdisciplinary Study Island Knowledge Lead Leadership Life Lung diseases Lupus Medical Mentors Methodology Minority Mission Morbidity - disease rate National Institute of Arthritis and Musculoskeletal and Skin Diseases Outcome Outcomes Research Pathogenesis Patient Care Patients Pilot Projects Population Prevalence Public Health Pulmonary Fibrosis Research Research Infrastructure Research Personnel Resources Rheumatism Rheumatology Risk Sampling Scleroderma Sea Severities Sierra Leone Solid South Carolina Staging Strategic Planning Systemic Lupus Erythematosus Systemic Scleroderma Translational Research Trust United States National Institutes of Health Universities Woman Work base clinical care design dissemination research genetic variant health disparity improved innovation interest minority health minority investigator mortality multidisciplinary novel outcome forecast patient population programs

项目摘要

The objective of this Multidisciplinary Clinical Research Center at the Medical University of South Carolina is the advancement of knowledge with respect to African Americans who have, or who are at risk of developing, systemic lupus erythematosus, systemic sclerosis, and other debilitating rheumatic diseases. The Center is built on a solid framework of strong leadership in Rheumatology, Biostatistics and Health Disparities Research coupled with trust and a proven track record of recruitment of African American patients for clinical research. Objectives of the Center are to: 1) conduct and foster translational clinical research leading to improved diagnosis, management and ultimately a reduction or elimination of health disparities with respect to debilitating rheumatic diseases in African Americans; 2) focus on identifying and understanding the underlying reasons for differences in risk profiles and disease progression for African Americans; 3) provide information and education to patients and families, healthcare providers, the general public, investigators and health professionals at other academic health centers and government agencies. We propose two innovative, high impact projects supported by three cores. Project 1 will investigate a genetic variant observed in African American SSc patients likely to be responsible for their higher severity of pulmonary fibrosis. This is highly significant given the morbidity and mortality rates, especially related to lung disease, in these patients. Project 2 addresses another significant health disparity, the increasing prevalence of lupus among African American women. The Sea Island Gullah people of South Carolina and individuals living in the Gullah ancestral home of Sierra Leone provide a novel opportunity to study genetic, environmental and epigenetic differences that might identify key factors associated with the development of SLE in African Americans. These two projects and future pilot projects will be served by three cores: (1) a Methodology Core will provide rigorous methodological and biostatistical support; (2) a Patient Resource Core will assure investigators access to patients and biological samples from SSc and SLE patients enriched with African Americans; (3) an Administrative Core will coordinate the work of the Center through planning, development, coordination and overall administration. With a sustained commitment of strong institutional support and through a robust pilot project program, this MCRC will attract and nurture young investigators with research interests in minority health and rheumatic diseases.

南卡罗来纳州医科大学这个多学科临床研究中心的目的是对有或有发育风险的非洲裔美国人的知识发展，这些人是系统性的红斑狼疮，系统性硬化症，系统性的硬化症和其他虚弱的流变疾病。该中心建立在风湿病学，生物统计学和健康差异研究以及信任以及招募非裔美国人患者进行临床研究方面的稳固框架上。该中心的目标是：1）进行和培养转化临床研究，从而改善诊断，管理，最终减少或消除健康差异，以使非洲裔美国人的风湿病衰弱； 2）专注于确定和理解非裔美国人风险概况和疾病进展差异的根本原因； 3）向其他学术卫生中心和政府机构的患者和家庭，医疗保健提供者，公众，调查人员和卫生专业人员提供信息和教育。我们提出了两个创新的高影响力项目，由三个核心支持。项目1将调查在非裔美国人SSC患者中观察到的一种遗传变异，可能是由于肺纤维化的较高严重程度。考虑到这些患者的发病率和死亡率，特别是与肺部疾病有关的发病率和死亡率，这是非常重要的。项目2解决了另一个重大的健康差异，这是非裔美国妇女中狼疮的越来越多。南卡罗来纳州的海岛古拉人民和居住在塞拉利昂古拉祖先住所的个人为研究遗传，环境和表观遗传学差异提供了新的机会，这些机会可能会发现与非裔美国人SLE发展相关的关键因素。这两个项目和未来的试点项目将由三个核心提供：（1）方法论核心将提供严格的方法论和生物统计支持；（2）患者资源核心将确保研究人员使用SSC的患者和生物样本的访问权限和富含非裔美国人的SLE患者的生物样本；（3）行政核心将通过计划，开发，协调和整体管理来协调中心的工作。通过持续强大的机构支持并通过强大的试点项目计划，该MCRC将吸引和培养年轻的研究人员，具有少数族裔健康和风湿病研究的研究兴趣。