Approaches for Synthesizing Data in Alcohol Research

酒精研究中的数据综合方法

• 批准号: 9065169
• 负责人: Angela Maria Haeny
• 金额: $ 3.51万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9065169
• 关键词: Alcohol abuse; Alcoholism; Area; Characteristics; Child; Competence; Data; Data Analyses; Data Set; Development; Diagnosis; Diagnostic; Discipline; Disease; Educational workshop; Effect Modifiers (Epidemiology); Environmental Risk Factor; Epidemiology; Family history of; Genetic study; Glass; Goals; Health; Impulsivity; Individual; Insurance Carriers; Knowledge; Literature; Low Prevalence; Measures; Mentors; Meta-Analysis; Methods; Nature; Negative Finding; Parents; Patients; Personality; Personality Traits; Policy Maker; Population; Prevalence; Prevention; Provider; Publishing; Reporting; Research; Research Personnel; Research Training; Risk; Science; Techniques; Training; alcohol research; alcohol use disorder; base; children of alcoholics; conditioning; endophenotype; experience; genetic pedigree; genetics of alcoholism; high risk; improved; insight; interest; intervention program; learning strategy; meetings; multilevel analysis; offspring; parental alcoholism; problem drinker; programs; prospective; psychosocial; skills; study characteristics; trait

 DESCRIPTION (provided by applicant): The broad goal of this proposal is to apply different methods for integrating data to alcohol research. Specifically, meta-analysis and integrative data analysis (IDA) will be used to answer to different research questions relating to the assessment of familial of alcoholism. This objective has implications across disciplines given that these methods can be applied to almost any topic within alcohol research and other fields. Specific Aims The first project, a meta-analysis on children of alcoholics (MOCA), consists of synthesizing the literature to further characterize the relationship between parental alcoholism and traits related to impulsivity in offspring and moderators of this relationship. The goal of MOCA is to identify, specifically, which traits related to impulsivity are associated with having a family history of parental alcoholism. Moderators that will be investigated include study characteristics such as the operationalization of parental alcoholism (e.g., child report of parent's alcohol problems versus assessing parent for alcohol problems). These objectives will be met through the utilization of advanced techniques such as meta-analytic multilevel modeling. The second project, an integrative data analysis of studies assessing lifetime alcohol use disorder (IDA-LAUD), will consist of integrating two data sets with multiple assessments of lifetime alcohol use disorder (AUD). The goal of this project is to further characterize reliabilit problems relating to false negatives in the assessment of lifetime AUD in more representative data sets. Although false negatives are a relatively low base rate phenomenon, the ramifications of its occurrence are severe. Utilizing IDA is the logical next step for further research in this area. Significance The results from MOCA will provide valuable information on the relationship between having a family history of parental alcoholism and impulsivity, which could be used to inform personality- tailored intervention programs. Additionally, the results from IDA-LAUD will provide valuable information on limitations in the assessment of lifetime AUD, which can be used to improve methods for assessing this and other related disorders.

 描述（由适用提供）：该提案的广泛目标是应用不同的方法将数据整合到酒精研究中。具体而言，荟萃分析和综合数据分析（IDA）将用于回答与酒精中毒家族有关的不同研究问题。鉴于这些方法可以应用于酒精研究和其他领域的任何主题，因此该目标具有跨学科的含义。具体的目标是第一个项目，是对酗酒儿童（MOCA）的荟萃分析，包括综合文献，以进一步表征父母酒精中毒与与这种关系的后代和主持人相关的与冲动性有关的特质之间的关系。 MOCA的目的是具体识别与冲动有关的特征与具有 父母酗酒的家族史。将进行研究的主持人包括研究特征，例如父母酒精中毒的操作（例如，父母的酒精问题报告与评估父母有关酒精问题的报告）。这些目标将通过利用高级技术（例如元分析多级建模）来实现。第二个项目是评估终身酒精使用障碍（IDA-LAUD）的研究的综合数据分析，将包括将两个数据集与终身酒精使用障碍（AUD）的多次评估相结合。该项目的目的是进一步表征与虚假的数据集评估相关的可靠性问题。尽管假阴性是一种相对较低的基本率现象，但其发生的后果很严重。利用IDA是该领域进一步研究的合理下一步。意义上的MOCA结果将提供有关父母酒精中毒家族史和冲动性之间关系的宝贵信息，这些信息可用于为人格量身定制的干预计划提供信息。此外，IDA-LAUD的结果将提供有关终生AUD评估局限性的宝贵信息，该信息可用于改善评估该疾病和其他相关疾病的方法。

项目成果

A scoping review and meta-analysis of psychosocial and pharmacological treatments for cannabis and tobacco use among African Americans.

• DOI: 10.1037/adb0000326
• 发表时间: 2017-12
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Montgomery L;Robinson C;Seaman EL;Haeny AM
• 通讯作者: Haeny AM