Understanding Race-Related Stress as a Mechanism Associated with Alcohol Craving to Inform Culturally-Adapting Alcohol Treatment for Black Adults

了解与种族相关的压力作为与酒精渴望相关的机制，为黑人成年人进行文化适应的酒精治疗提供信息

• 批准号: 10214970
• 负责人: Angela Maria Haeny
• 金额: $ 19.39万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10214970
• 关键词: Address; Adult; Alcohol consumption; Area; Clinical; Clinical Research; Clinical Trials; Cognitive Therapy; Collaborations; Communities; Coping Skills; Cues; Data; Data Collection; Development; Discrimination; Disease; Dropout; Ethnic group; Event; Future; Goals; Imagery; Individual; Intervention; Interview; Knowledge; Laboratories; Lead; Learning; Legal; Link; Mentorship; Minority; Modeling; Music; Outcome; Participant; Pilot Projects; Police; Population; Procedures; Process; Qualitative Methods; Qualitative Research; Race; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Training; Resources; Severities; Stress; Stressful Event; Syphilis; Taxes; Testing; Training; Trust; Work; acceptability and feasibility; alcohol abuse therapy; alcohol craving; alcohol cue; alcohol misuse; alcohol relapse; alcohol related consequences; alcohol use disorder; base; career; community based participatory research; coping; craving; drinking; experience; follow-up; health disparity; improved; individualized medicine; maltreatment; medical schools; preference; racial and ethnic; racism; satisfaction; skills; stressor; therapy development; treatment disparity; treatment group; treatment research

Abstract Black people (BP) who use alcohol experience among the highest rate of alcohol-related consequences, yet only a small percentage of BP with alcohol use disorder (AUD) receive treatment. This disparity in treatment unmet need among BP highlights the necessity of efficacious alcohol treatments for this group. Among BP who receive alcohol treatment, they tend report lower satisfaction with treatment and have higher dropout rates. Culturally tailoring treatment has been proposed as one approach that might increase treatment satisfaction and retention among BP. Given that extensive research links stress to alcohol craving and relapse, and Minority Stress Models indicate that BP experiences stressors specific to being Black, incorporating race-related stress (RRS) is a reasonable target for adapted alcohol treatments for this group. Although prior research shows RRS such as discrimination predict alcohol misuse among BP, prior research has not investigated alcohol craving as a potential mechanism that links RRS to alcohol misuse among BP. In addition, knowledge of cues associated with drinking may be important for informing alcohol treatment adaptations for BP. Further, knowledge of neutral/relaxing events could inform coping strategies to include in alcohol treatment for BP. The proposed research will: [1) identify specifically which stressors and types of alcohol cues trigger alcohol craving and strategies for coping among BP; 2) provide an in-depth understanding of the impact of race-related stress (RRS) on alcohol craving; 3) identify other factors associated with the Black experience that contribute to AUD and should be included in AUD treatment for this group; and 4) provide evidence of the feasibility and acceptability of culturally-adapting an early CBT session based on these factors.] Completing this research will support my development as an independent alcohol treatment researcher with a focus on priority populations (e.g., Black people) and my career goals to [1) conduct meaningful research with hard to reach populations; 2) investigate coping strategies and mechanisms that maintain AUD among BP, and 3) lead rigorous clinical trials research to develop and test culturally-informed treatments for Black adults with AUD.] I will achieve my research and career goals through training and mentorship by experts in: alcohol treatment research (Dr. Stephanie O’Malley), personalized imagery procedures and stress and craving research (Dr. Rajita Sinha), RRS and treatment adaptations for BP (Dr. Monnica Williams), treatment development and adaptations (Dr. Kathleen Carroll), and community-based participatory and qualitative research methods (Dr. Larry Davidson), and collaboration with a biostatistician with expertise in clinical trials research (Dr. Ralitza Gueorguieva). My research and training will be completed at Yale School of Medicine, which has an abundance of physical and intellectual resources. Receiving this training and completing this research will support my long-term career goal to eliminate treatment health disparities among BP with AUD.

抽象的 黑人（BP）在最高的酒精相关后果中使用酒精经验，但仅 一小部分酒精使用障碍的BP接受治疗。治疗中的这种差异未满足 BP中的需求突出了该组有效的酒精治疗所必需的。在接受的BP中 酒精治疗，他们倾向于报告对治疗的满意度较低，并且辍学率较高。在文化上 裁缝治疗已被认为是一种可能提高治疗满意度和保留率的方法 在BP中。鉴于广泛的研究将压力与酒精渴望和继电器联系起来，以及少数压力模型 表明BP体验特定于黑色的压力源，并纳入与种族相关的压力（RRS）是一个 该组适应性酒精治疗的合理目标。尽管先前的研究表明RR等RR 歧视预测BP滥用酒精，先前的研究并未投资渴望作为一种 将RR与BP之间的酒精滥用联系起来的潜在机制。此外，了解相关的提示知识 喝酒可能对于告知BP的酒精治疗适应至关重要。此外，知识 中性/放松的事件可以为应对策略提供信息，以包括BP的酒精治疗。提议 研究将：[1）具体确定哪些压力源和类型的酒精提示引发酒精渴望和 BP之间应对的策略； 2）深入了解与种族相关压力（RRS）的影响 渴望酒精； 3）确定与黑人体验相关的其他因素，这些因素有助于AUD和 该组应包括在AUD治疗中； 4）提供可行性和可接受性的证据 基于这些因素，对文化适应早期的CBT会议。]完成这项研究将支持我 作为一名独立酒精治疗研究人员的发展，重点是优先人群（例如，黑色 人）和我的职业目标[1）进行有意义的研究，以难以到达人口； 2）调查 应对维持BP的AUD的应对策略和机制，以及3）领导严格的临床试验研究 使用AUD开发和测试黑人成年人的文化知识治疗。]我将实现我的研究和职业 通过专家的培训和心态的目标：酒精治疗研究（Stephanie O'Malley博士）， 个性化的图像程序，压力和渴望研究（Rajita Sinha博士），RRS和治疗 BP（Monnica Williams博士）的适应，治疗开发和适应（Kathleen Carroll博士）和 基于社区的参与和定性研究方法（Larry Davidson博士），并与 生物统计学家具有临床试验研究专业知识（Ralitza Gueorguieva博士）。我的研究和培训将是 在耶鲁大学医学院完成，该学院拥有丰富的物理和智力资源。接收 这项培训并完成这项研究将支持我消除治疗健康的长期职业目标 BP与AUD之间的差异。