Support For Infrastructure of Childhood Leukemia Environmental Research

支持儿童白血病环境研究基础设施

基本信息

批准号：
10588560
负责人：
Catherine Metayer
金额：
$ 38.61万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588560
关键词：
Acceleration Acute Lymphocytic Leukemia Acute Myelocytic Leukemia Address Affect Asian Awareness Birth Weight Breast Feeding California Case/Control Studies Chemical Exposure Chemicals Child Childhood Childhood Leukemia Collaborations Communities Costa Rica Costa Rican Country Data Data Sources Databases Developed Countries Development Diet Disease Disparity Education Education and Outreach Educational workshop Enrollment Environment Environmental Epidemiology Environmental Health Environmental Risk Factor Equipment and supply inventories Ethnic Population Etiology Exposure to FAIR principles Funding Genetic Goals Guatemala Health Health Professional Hispanic Immune Immune response Incidence Individual Infrastructure Institution International Investigation Latin America Latin American Latinx Latinx population Link Maintenance Malignant Childhood Neoplasm Malignant Neoplasms Mexican Mexico Multimedia Myelogenous National Institute of Environmental Health Sciences Neighborhoods Outcome Outcome Study Population Population Heterogeneity Population Study Prevention Procedures Prognosis Public Health Publications R24 Recording of previous events Research Research Personnel Resource Sharing Resources Risk Risk Factors Role Seminal Socioeconomic Status Source Survivors System Translational Research Tumor Biology United States Vitamins Vulnerable Populations bilingualism built environment carcinogenicity case control community engagement data archive data sharing data sharing networks design dietary disorder risk electronic book epidemiology study ethnic diversity genetic risk factor health organization improved interoperability leukemia medical specialties outreach prenatal process improvement public database racial population social social factors stressor survivorship trend webinar

项目摘要

ABSTRACT Leukemia is the most common pediatric cancer affecting more than 40,000 children worldwide each year. During the last decades, childhood leukemia incidence has increased in the US by ~35% overall, with an even larger rise among LatinX. Similar trends are also observed in several Latin American countries. This rapid increase points to the critical role of environmental factors in the development childhood leukemia, possibly in combination with genetic factors. Despite improved prognosis of childhood leukemia overall, there are major differences by subtype, region, racial/ethnic group, and socio-economic status, and leukemia survivors remain at risk for serious lifelong complications. Altogether, these observations highlight the need to support more research and prevention to reduce leukemia burden and disparity. The overall objective of this U24 competing renewal is to expand the support of existing population studies (here case-control design) to accelerate childhood leukemia environmental research and prevention, with a focus on LatinX populations. In the first R24 cycle (2017-22), we maintained and enhanced the resources and data sharing of two NIEHS-funded studies with large numbers of LatinX children in California, United States and Guatemala. To further address childhood leukemia disparity in LatinX, while increasing diversity of the research team, we now propose to (i) include additional childhood leukemia studies with low-resources in Mexico and Costa Rica, (ii) coordinate research translation/prevention among participating countries, and (iii) collaborate with LatinX researchers and health workers in California and Latin America. The four participating studies have enrolled 8,480 childhood leukemia cases and 4,462 controls, and have collected a wealth of environmental/genetic data and biospecimens providing the most comprehensive resources in LatinX populations worldwide. Individually or as part of the Childhood Cancer and Leukemia Consortium (CLIC), these studies have produced seminal findings, documenting the prenatal origin of childhood leukemia and identifying many factors that contribute to the increased or decreased risks of the disease including chemical exposures, diet/vitamins, breastfeeding, immune response, birthweight and genetic factors. The maintenance of these resources and the enhancement of data sharing procedures are needed to efficiently expand ongoing etiologic and tumor-biology studies of childhood leukemia, especially myeloid subtypes which are more common in LatinX, and uncover sources of disparity in leukemia risk and outcomes. To achieve our goals, we plan to (1) use an interoperable management system REDCap to provide unifying support for management, harmonization, storage and sharing of study resources; (2) enrich case-control studies by conducting linkages to population-level databases on exposures to potential carcinogenic agents/mixtures and social/built environments; (3) facilitate broader data use nationally and internationally with the CLIC Consortium, and (4) expand community engagement with the public, lay health workers, and health professionals in the US and Latin American countries to increase awareness about preventable risk factors of childhood leukemia.

抽象的白血病是最常见的儿科癌症，每年影响全球超过 40,000 名儿童。期间过去几十年来，美国儿童白血病发病率总体增加了约 35%，增幅更大在拉丁裔中崛起。一些拉丁美洲国家也观察到类似的趋势。这种快速增长指出环境因素在儿童白血病发展中的关键作用，可能是多种因素共同作用的结果与遗传因素有关。尽管儿童白血病的预后总体上有所改善，但仍存在重大差异亚型、地区、种族/族裔群体和社会经济地位以及白血病幸存者仍然面临严重的风险终生并发症。总而言之，这些观察结果强调需要支持更多的研究和预防以减少白血病负担和差异。此次 U24 竞争续约的总体目标是扩大对现有人口研究（此处为病例对照设计）的支持，以加速儿童白血病的发展环境研究和预防，重点关注拉丁裔人群。在第一个 R24 周期（2017-22）中，我们维护并加强了两项 NIEHS 资助的研究的资源和数据共享加利福尼亚州、美国和危地马拉的拉丁裔儿童。进一步解决儿童白血病的差异 LatinX，在增加研究团队多样性的同时，我们现在建议 (i) 纳入额外的童年墨西哥和哥斯达黎加资源匮乏的白血病研究，(ii) 协调研究转化/预防参与国家之间的合作，以及 (iii) 与加利福尼亚州的拉丁研究人员和卫生工作者合作拉美。四项参与研究共招募了 8,480 名儿童白血病病例和 4,462 名对照者，并收集了大量的环境/遗传数据和生物样本，提供最全面的全球拉丁裔人群的资源。单独或作为儿童癌症和白血病的一部分联盟（CLIC），这些研究产生了开创性的发现，记录了童年的产前起源白血病并确定导致该疾病风险增加或减少的许多因素，包括化学品暴露、饮食/维生素、母乳喂养、免疫反应、出生体重和遗传因素。这需要维护这些资源并加强数据共享程序，以有效地扩大正在进行的儿童白血病的病因学和肿瘤生物学研究，特别是骨髓亚型，在拉丁裔中更为常见，并揭示了白血病风险和结果差异的根源。为了实现我们的目标，我们计划 (1) 使用可互操作的管理系统 REDCap 为管理、协调、存储和共享学习资源； (2) 丰富病例对照研究与有关潜在致癌剂/混合物暴露情况的人口级数据库建立联系，社会/建筑环境； (3) 与 CLIC 联盟一起促进国内和国际更广泛的数据使用， (4) 扩大美国公众、非专业卫生工作者和卫生专业人员的社区参与和拉丁美洲国家提高对儿童白血病可预防危险因素的认识。