Childhood Leukemia International Consortium Scientific Annual Meetings

儿童白血病国际联盟科学年会

• 批准号: 9418611
• 负责人: Catherine Metayer
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9418611
• 关键词: Accidents; Address; Area; Asia; Astrocytoma; Brain Neoplasms; Case-Control Studies; Cause of Death; Central America; Child; Childhood Leukemia; Communication; Country; Data; Data Analyses; Data Coordinating Center; Decision Making; Development; Environment; Environmental Risk Factor; Ependymoma; Epigenetic Process; Etiology; Family; France; Future; Genes; Genetic; Glioma; Goals; Hodgkin Disease; Individual; International; International Agency for Research on Cancer; Intracranial Neoplasms; Knowledge; Literature; Malignant Childhood Neoplasm; Malignant Neoplasms; Manuscripts; Meta-Analysis; Methodology; Non-Hodgkin' s Lymphoma; Persons; Population; Preparation; Principal Investigator; Publications; Request for Proposals; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; South America; Statistical Methods; Teleconferences; Translational Research; United States National Institutes of Health; Work; base; cancer diagnosis; case control; clinical risk; data sharing; data warehouse; epidemiologic data; genetic risk factor; genome wide association study; knowledge base; leukemia; medulloblastoma; meetings; member; public health relevance; research data dissemination; success; validation studies

 DESCRIPTION (provided by applicant): The Childhood Leukemia International Consortium (CLIC), established in 2007, is a group of independent, international researchers who study the role of environmental, genetic, infectious, and clinical risk factors in the etiology of childhood leukemia and who share data from case-control and family-based trio studies. CLIC includes 33 childhood leukemia case-control studies worldwide from 17 countries (25 Principal Investigators) representing approximately 20,000 cases and 200,000 controls. Approximately 90% of the studies have comprehensive epidemiologic data, and about half have biospecimens. CLIC is expanding its research portfolio to include childhood cancers other than leukemia, which will enable the Consortium to pool resources and data across 16 other childhood cancers (e.g., 12 studies on intracranial tumors, 11 studies on astrocytoma, 10 studies on ependymomas, 8 studies on medulloblastomas, 9 studies on other gliomas, and 9 studies on both Hodgkin and non-Hodgkin lymphomas, etc.). Though CLIC members participate in teleconferences throughout the year, the annual in-person meeting for members is essential for planning and evaluating progress on collaborative research projects, and discussing new research directions. The next three CLIC annual meetings (2015-2017) will provide a forum for continuing discussions and increasing the knowledge base of members. It will also achieve the following goals: * Plan and conduct genetic and gene-environment pooled and validation studies in childhood leukemia; discuss future epigenetic studies. * Discuss expanding CLIC to include other childhood cancers, especially brain tumors, which will take advantage of our existing infrastructure, collegial relationships, and knowledge; evaluate current literature to identify gaps in research where CLIC can best contribute. * Identify and address methodological challenges such the impact of possible selection and recall bias, application of statistical methods for causal inference. * Partner with leading national institutes of health to identify potential studies of under-represented children with cancers; encourage participation and increase membership of under-represented populations from Central and South America and Asia. * Discuss and identify research areas most suitable for quantitative research translation, research dissemination and communication to stakeholders.

 描述（由申请人提供）：儿童白血病国际联盟 (CLIC) 成立于 2007 年，是一个由独立的国际研究人员组成的小组，研究环境、遗传、感染和临床危险因素在儿童白血病病因学中的作用以及CLIC 共享病例对照和基于家庭的三项研究的数据，包括来自 17 个国家的 33 项儿童白血病病例对照研究（25 名主要研究者）。 20,000 个病例和 200,000 个对照。大约 90% 的研究拥有全面的流行病学数据，大约一半的研究拥有生物样本。CLIC 正在扩大其研究范围，将儿童癌症纳入其中，这将使联盟能够汇集其他 16 个领域的资源和数据。儿童癌症（例如，12 项颅内肿瘤研究、11 项星形细胞瘤研究、10 项研究室管膜瘤研究、髓母细胞瘤研究 8 项、其他胶质瘤研究 9 项、霍奇金淋巴瘤和非霍奇金淋巴瘤研究 9 项等）。 尽管 CLIC 成员全年都会参加电话会议，但每年一次的面对面会议对于规划和评估合作研究项目的进展以及讨论新的研究方向至关重要。接下来的三届 CLIC 年会（2015-2017 年）将提供一个机会。继续讨论和增加成员知识库的论坛还将实现以下目标： * 规划并开展儿童白血病的遗传和基因环境汇总及验证研究；讨论未来的表观遗传学研究。 * 讨论扩大 CLIC 以包括其他儿童癌症，特别是脑肿瘤，这将利用我们现有的基础设施、同事关系和知识；评估当前文献，以确定 CLIC 可以做出最大贡献的研究空白。 * 识别并解决方法上的挑战，例如可能的选择和回忆偏差的影响、因果推断统计方法的应用。 * 与领先的国家卫生机构合作，确定针对代表性不足的癌症儿童的潜在研究；鼓励中美洲、南美洲和亚洲代表性不足的人群参与并增加其成员数量。 * 讨论并确定最适合定量研究转化、研究传播和与利益相关者沟通的研究领域。