Biomaterials that Promote Infection Immunity

促进感染免疫的生物材料

基本信息

批准号：
7632284
负责人：
James D. Bryers
金额：
$ 49.63万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-07 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7632284
关键词：
2-hydroxyethyl methacrylate Affect Air American Ammonium Anti-Infective Agents Antibiotic Therapy Antibiotics Antibodies Antibody Formation Antigen Presentation Antigen-Presenting Cells Antigens Artificial Heart Artificial cardiac pacemaker B-Cell Activation B-Lymphocytes Bacteria Bacterial Adhesins Binding Biocompatible Materials Biological Blood Vessel Prosthesis Cardiovascular system Catheters Cause of Death Cells Centers for Disease Control and Prevention (U.S.)Cerebrospinal fluid shunts procedure Cessation of life Chimeric Proteins Chlorhexidine Ciprofloxacin Code Communities Contact Lenses Control Groups Coupled Coupling Dendritic Cells Device Removal Devices Dose Drug Formulations Engineering Epitopes Escherichia coli Exhibits Exposure to FCGR3B gene Fibronectins Figs - dietary Generic Drugs Genes Goals Growth Healed Heart Valve Prosthesis Hospitals Human Hydrogels Immune response Immunity Immunization Implant In Vitro Indwelling Catheter Infection Inflammatory Intrauterine Devices Invaded Left Liquid substance MHC Class I Genes MHC Class II Genes Mechanics Medical Medical Device Memory B-Lymphocyte Messenger RNA Methods Microbial Biofilms Modeling Monoclonal Antibodies Mus Nosocomial Infections Ocular Prosthesis Opsonin Organism Orthopedics Particulate Patients Performance Phagocytosis Pharmaceutical Preparations Polymers Prosthesis Recombinants Research Project Grants Residual state Series Silver Skin Staging Staphylococcus epidermidis Surface System T-Lymphocyte Therapeutic Time Transfection United States National Institutes of Health Vaccines Virulence Factors antimicrobial base controlled release cost design healing implantable device implantation in vivo killer T cell killings macrophage meetings microbial monocyte monomer novel particle poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer prevent protein complex public health relevance receptor receptor binding response scaffold stressor success trafficking uptake urinary vector vector vaccine ventricular assist device

项目摘要

DESCRIPTION (provided by applicant): Nosocomial infections are the fourth leading cause of death in the U.S. with >2 million cases annually (or ~10% of American hospital patients). About 60% of these infections are associated with an implanted medical device causing >$4.5 billion medical costs in 1992 and ~80,000 deaths annually. It is estimated that over 5 million artificial or prosthetic parts are implanted per annum in the U.S. alone. Our goal, with NIH support, is to engineer biomaterials that will solicit a short- and long-term immune response to specific bacterial colonization. For short-term immediate defense, model biomaterials will release fusion protein complexes - artificial opsonins - designed to enhance the coupling of invading bacteria to monocyte/macrophage (MO); thus promoting phagocytosis. For long-term protection, the biomaterial will transfect antigen-presenting cells (specifically dendritic cells - DCs) to produce T- and B-cell memory and antibody expression, and potentially stimulate direct native killer T-cell responses. PUBLIC HEALTH RELEVANCE: It is estimated that over 5 million artificial or prosthetic devices are implanted per annum in the U.S. alone. However, 70% of hospital-acquired infections are associated with implants or indwelling medical devices, with the case-to-fatality ratio between 5-50%. In this 5-yr NIH RO1 research grant, we will develop a novel class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections.

描述（由申请人提供）：医院感染是美国的第四大死亡原因，每年约200万例（约占美国医院患者的10％）。这些感染中约有60％与植入的医疗装置有关，1992年造成45亿美元的医疗费用，每年约80,000例死亡。据估计，仅在美国，每年就会植入超过500万个人造或假肢零件。在NIH支持的情况下，我们的目标是设计生物材料，该材料将征求对特定细菌定植的短期和长期免疫反应。对于短期立即防御，模型生物材料将释放融合蛋白复合物 - 人造opsonins-旨在增强入侵细菌与单核细胞/巨噬细胞（MO）的偶联；从而促进吞噬作用。为了长期保护，生物材料将转染抗原呈递细胞（特异性树突状细胞-DC），以产生T-和B细胞记忆和抗体表达，并可能刺激直接的天然杀手T细胞反应。公共卫生相关性：据估计，仅在美国，每年就会植入超过500万个人工或假体设备。然而，70％的医院获得感染与植入物或留置医疗设备有关，病例与美国的病情比率在5-50％之间。在这项5年的NIH RO1研究赠款中，我们将开发一类新型的生物材料，这些生物材料可以促进愈合，同时预防细菌定殖和随后的感染。