Basic Science Core - Biosafety & Biocontainment Core (BBC)

基础科学核心 - 生物安全

• 批准号: 10588216
• 负责人: Jordi B Torrelles
• 金额: $ 17.38万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588216
• 关键词: Accidents; Address; Aerosols; Antibiotics; Basic Science; Bioenergetics; Biomedical Research; Blood; Cell Separation; Clinical; Containment; Decontamination; Drug resistant Mycobacteria Tuberculosis; Educational Curriculum; Electron Spin Resonance Spectroscopy; Emergency Situation; Emergency response; Emerging Technologies; Ensure; Environment; Equipment; Genomics; Genus Hippocampus; Goals; Immunohistochemistry; In Vitro; Infection; Infectious Agent; Knowledge; Laboratories; Learning; Maintenance; Measures; Medical emergency; Metabolic; Methods; Mycobacterium tuberculosis; Mycobacterium tuberculosis complex; Oral; PET/CT scan; Participant; Phase; Predisposition; Procedures; Research; Research Institute; Research Personnel; Resource-limited setting; Risk; Risk Assessment; Rodent; Safety; Source; Techniques; Texas; Training; Training Programs; Training Technics; Tuberculosis; Work; Writing; X-Ray Computed Tomography; biocontainment facility; biosafety level 3 facility; career; cellular imaging; co-infection; cytate; design; experience; experimental study; hazard; in vivo; in vivo imaging system; innovation; knowledgebase; laboratory experience; man-made disasters; microscopic imaging; multidisciplinary; new technology; next generation; nonhuman primate; operation; personal protective equipment; programs; response; risk mitigation; skills; success

Texas Biomed IN-TRAC Biosafety & Biocontainment Core (BBC) – ABSTRACT The goal of this core is to establish a personalized Biosafety & Biocontainment training curriculum for the next generation of tuberculosis (TB) researchers in order to prepare them to work and excel within the biocontainment environment performing studies to advance the field. For a new investigator pursuing TB research as well as for well-established investigators who want to enter the TB research field, it is critical for them to understand biosafety and the biocontainment environment, including knowledge of the strengths and limitations of working in biocontainment, in order for them to achieve their career goals. The ability to properly conduct risk assessment including a thorough understanding of equipment and procedures in biocontainment, will further ensure innovations in TB research, especially in resource limited areas. Our Aims are to: Aim 1. Establish and manage a personalized Biosafety & Biocontainment curriculum. In this Aim a phased approach (assessment and didactic phases) will be implemented to provide comprehensive and customized training. Aim 2. Execute a Biosafety & Biocontainment training program for IN-TRAC participants. In this aim, a personalized Biocontainment training program established for each IN-TRAC participant will be executed. Participants will learn how to function safely and effectively in a high-containment BSL3 facility. We will divide this into three segments: Biocontainment facility operations, General Procedures and Emergency Response Drills. Aim 3. Apply risk assessment and mitigation strategies to emerging technology and multi-hazard scenarios. New technology often introduces unforeseeable biosafety risks. Equipped with general biocontainment and M.tb procedure-specific knowledge, participants will be able to properly evaluate and implement procedures when encountering emerging technology and develop procedures to safety achieve their research goals. Upon completion of this core curriculum, new TB researchers will be prepared/proficient in working in a biocontainment environment, including general and specialized techniques required for success in the TB field. Importantly, IN-TRAC participants will prepare a written and oral summary about the strengths and weaknesses of experience for the IN-TRAC program.

Texas Biomed IN-TRAC 生物安全和生物防护核心 (BBC) – 摘要 该核心的目标是为未来建立个性化的生物安全和生物防护培训课程 培养结核病 (TB) 研究人员，帮助他们做好在生物遏制领域工作并取得优异成绩的准备 对于从事结核病研究的新研究者以及为了推进该领域的研究环境。 对于想要进入结核病研究领域的知名研究人员来说，了解这一点至关重要 生物安全和生物防护环境，包括工作优势和局限性的知识 生物防护领域，以便他们能够正确进行风险评估。 包括对生物防护中的设备和程序的透彻了解，将进一步确保 结核病研究的创新，特别是在资源有限的领域，我们的目标是： 目标 1. 建立和管理。 个性化的生物安全和生物防护课程在此目标中采用分阶段的方法（评估和实施）。 将实施教学阶段）以提供全面和定制的培训。 目标 2. 执行 为此，我们为 IN-TRAC 参与者提供了个性化的生物安全和生物防护培训计划。 将执行为每个 IN-TRAC 参与者制定的生物防护培训计划。 了解如何在高度封闭的 BSL3 设施中安全有效地运作我们将其分为三部分。 部分：生物防护设施运营、一般程序和应急响应演习目标 3。 将风险评估和缓解策略应用于新兴技术和多灾害场景。 新技术往往会带来不可预见的生物安全风险。 程序特定的知识，参与者将能够正确评估和实施程序 遇到新兴技术并开发程序以安全地实现其研究目标。 完成本核心课程后，新的结核病研究人员将做好准备/熟练地工作 生物防护环境，包括结核病领域成功所需的通用和专业技术。 重要的是，IN-TRAC 参与者将准备一份关于优势和劣势的书面和口头总结 IN-TRAC 计划的经验。