Clinical Research Design, Epidemiology, and Biostatistics Core

临床研究设计、流行病学和生物统计学核心

• 批准号: 8948611
• 负责人: CHRISTOPHER H. SCHMID
• 金额: $ 79.59万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8948611
• 关键词: Academic Training; Applications Grants; Award; Biometry; Biostatistics Core; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Collection; Consultations; Data; Development; Devices; Diagnosis; Discipline; Education; Ensure; Environment; Epidemiologic Methods; Epidemiology; Goals; Grant; Health Services; Healthcare Systems; Hospitals; Institution; Interdisciplinary Study; Laboratories; Mentors; Methodology; Methods; Pathway interactions; Patients; Pharmacy facility; Play; Procedures; Process; Public Health Schools; Quality Control; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Rhode Island; Role; Services; Statistical Methods; Students; Techniques; Testing; Training; Translating; Translational Research; Universities; Work; abstracting; base; career; collaborative environment; college; design; disorder prevention; experience; high standard; improved; innovation; medical schools; method development; multidisciplinary; programs; tool

ABSTRACT – CLINICAL RESEARCH DESIGN, EPIDEMIOLOGY AND BIOSTATISTICS CORE Use of robust study design with modern statistical and epidemiologic methods plays an essential role in integrated, multidisciplinary research teams created to optimize the pathway from the development of new treatments, techniques and devices in the laboratory to their application for improved diagnosis, treatment, and prevention of disease of patients. We propose to develop the Clinical Research Design, Epidemiology, and Biostatistics Key Component of the RI-CCTS to provide expertise and resources to facilitate research across institutional boundaries that will increase the capacity, sophistication, and application of contemporary analytical approaches to transform clinical and translational research in Rhode Island. The Key Component will connect strong but isolated research units scattered throughout Brown University Alpert Medical School and its seven affiliated hospitals, Brown School of Public Health and University of Rhode Island College of Pharmacy. Current collaboration among these entities has relied on ad hoc analytic teams that do not interface and study design mentoring with no unified core. As a result, methods expertise has failed to reach a broad clinical audience, existing teams have not benefited from others' experience and new methods and tools are not widely distributed. We aim to create a central “storefront” through which investigators could access all of the research tools available throughout the state and research training from its renowned academic affiliates. In order to develop this program, we propose the following three Specific Aims: Specific Aim 1: Services & Resources: Develop an easily accessible multidisciplinary, integrated center that provides support to clinical and translational investigators in study design as well as collection, management, analysis, interpretation and presentation of data using procedures that ensure quality control and reproducibility of all analyses Specific Aim 2: Education & Mentoring: Develop and offer training materials in study design, epidemiology and biostatistics for early and mid-career investigators as well as provide training in statistical collaboration and consultation for core statistical staff and student consultants Specific Aim 3: Tools & Method Development: Provide a supportive environment to enable clinical investigators and statistical analysts to develop, validate and disseminate innovative design and analytical methodology arising from clinical and translational research problems The proposed Key Component will transform clinical and translational research in Rhode Island by creating universal access to critical expertise, tools and resources. This access will reach young investigators receiving Pilot Awards and clinicians in isolated environments. It will train young methodologists in research collaboration and provide young and old with a wider range of problems on which to develop and test innovative solutions.

摘要 - 临床研究设计，流行病学和生物统计学核心 使用现代统计和流行病学方法的强大研究设计在 创建的综合，多学科研究团队是为了优化新开发的途径 实验室中的治疗，技术和设备，以改善诊断，治疗和 预防患者疾病。我们建议开发临床研究设计，流行病学和 RI-CCT的生物统计学关键组成部分提供专业知识和资源，以促进研究 机构边界将增加当代的能力，复杂和应用 转化罗德岛州临床和翻译研究的分析方法。关键组件将 连接散布在布朗大学Alpert医学院及其的强大但孤立的研究单位及其 七家会员医院，布朗公共卫生学院和罗德岛大学药学院。 这些实体之间的当前合作依赖于不接口和研究的临时分析团队 设计心理，没有统一的核心。结果，方法专家未能达到广泛的临床 受众，现有团队并未从他人的经验中受益，新的方法和工具不是 分布广泛。我们旨在创建一个中心的“店面”，调查人员可以通过该中心 全州可用的研究工具以及其著名学术分支机构的研究培训。在 为了制定此程序，我们提出以下三个具体目标： 特定目标1：服务与资源：开发一个易于访问的多学科，集成中心 为临床和翻译的研究设计师提供支持以及收集，管理， 使用程序来分析，解释和呈现数据，以确保质量控制和 所有分析的可重复性 特定目的2：教育与指导：开发和提供研究设计，流行病学的培训材料 以及早期和中期研究人员的生物统计学，以及提供统计合作的培训 核心统计人员和学生顾问咨询 特定目的3：工具和方法开发：提供支持的环境以实现临床 研究人员和统计分析师开发，验证和传播创新设计和分析 临床和翻译研究问题引起的方法论 拟议的关键组件将通过创建罗德岛的临床和翻译研究 普遍获取关键专业知识，工具和资源。此访问将吸引年轻的调查人员接收 在孤立环境中的飞行员奖和临床医生。它将在研究合作中培训年轻的方法论家 并为年轻人提供各种各样的问题，以开发和测试创新的解决方案。