Pilot and Feasibility Program

试点和可行性计划

• 批准号: 10612975
• 负责人: Utpal Pajvani
• 金额: $ 11.38万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612975
• 关键词: Academic Medical Centers; Achievement; Adult; Applications Grants; Award; Categories; Childhood; Clinical; Collaborations; Data; Development; Digestive System Disorders; Doctor of Philosophy; Education; Educational workshop; Eligibility Determination; Extramural Activities; Faculty; FarGo; Funding; Funding Mechanisms; Future; Goals; Grant; Grant Review; Growth; Institution; Investments; Liver diseases; Medical center; Mentors; Mentorship; Mission; Monitor; Outcome; Peer Review; Publications; Qualifying; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Science; Scientist; Services; Talents; Training; United States National Institutes of Health; Universities; career; career development; clinical center; equity, diversity, and inclusion; experience; falls; high reward; high risk; innovation; member; next generation; operation; programs; scientific organization; success

SUMMARY The Pilot/Feasibility (P/F) Program represents a central component of the Columbia University Digestive and Liver Disease Research Center (CU-DLDRC). Its primary objectives will be the promotion of highly innovative research and the expansion of digestive disease-related research opportunities to new investigators. The P/F Program is built on a long history of successful pilot funding and career building of junior PIs within Columbia University Medical Center (CUIMC). We successfully established this program in 2019 and have funded seven investigators thus far, who have enjoyed a high rate of success in obtaining NIH or equivalent funding, providing a >25-fold rate of return. The P/F is led by two directors with outstanding expertise in adult and pediatric digestive disease research and administration, Drs. Kara Margolis and Dr. Utpal Pajvani. The P/F Program will provide three grants of $25k each year, two from CU-DLDRCC funds and another from institutional support, that will enable eligible investigators to explore hypotheses related to one of the two central themes of the CU-DLDRCC, in order to gather sufficient data to develop research programs and grant applications for peer-reviewed extramural funding. The P/F awards fund different tracks, in prioritized order. Track 1: New investigators seeking initial support. Track 2: New or established investigators aiming to pursue innovative high-risk, high-reward projects in digestive disease. Track 3: Established investigators from other fields who seek to apply their expertise to research in digestive disease. The P/F Program will be highly synergistic with other translationally and clinically focused intramural internal funding mechanisms at CUIMC. P/F awardees will enjoy additional benefits that will substantially promote their research, including Biomedical Core subsidies that go far beyond the funding duration; integration into our comprehensive academic mentorship program via the Enrichment Program integration as well as into CU-DLDRC activities in research and education such as clinical-basic teams, workshops and seminars. The P/F program will contribute to the mission of the CU-DLRDC through three Specific Aims: To solicit and rigorously peer review applications, thereby supporting highly innovative research as well as rising stars in digestive research (Aim 1); to maximize the success of P/F-funded researchers through opportunities for scientific interactions, education, training and mentorship as well as CU-DLDRC core subsidies (Aim 2); and to provide efficient oversight of P/F program outcomes through long-term tracking of awardees publications and grants (Aim 3). We anticipate the P/F program to enhance the development of the highly diverse basic and clinical talent and to promote innovative impactful science beyond the horizon of current digestive research. These three Aims will be under the goal of increasing Diversity, Equity and Inclusion (DEI), through collaboration with the Enrichment Program, its DEI delegate and the wide range of DEI resources at Columbia. We have achieved initial success already, leveraging CU-DLDRC and institutional collaborations and resources.

概括 试点/可行性（P/F）计划代表哥伦比亚大学消化道的核心组成部分 肝病研究中心（CU-DLDRC）。它的主要目标是促进高度创新的目标 研究与消化疾病相关的研究机会的扩展向新研究者。 P/f 计划建立在哥伦比亚境内成功的飞行员资金和职业生涯的悠久历史上 大学医学中心（CUIMC）。我们在2019年成功建立了该计划，并资助了七个计划 迄今为止，调查人员在获得NIH或同等资金方面取得了很高的成功率 回报率> 25倍。 P/F由两位董事领导，在成人和小儿消化方面具有出色的专业知识 疾病研究与管理，博士。卡拉·玛格利斯（Kara Margolis）和Utpal Pajvani博士。 P/F计划将提供 每年的三项赠款为25,000美元，两支来自Cu-dldrcc资金，另一项来自机构支持，这将 使符合条件的研究人员能够探索与Cu-dldrcc的两个中心主题之一有关的假设， 为了收集足够的数据以制定研究计划并授予同行评审的应用程序 壁外资金。 P/F奖项以优先顺序为不同的曲目提供了资金。曲目1：新的调查人员寻求 初始支持。曲目2：旨在追求创新的高风险，高回报的新的或已建立的调查员 消化疾病的项目。轨道3：来自其他领域的既定调查员 研究消化疾病研究的专业知识。 P/F计划将与其他翻译相同 以及CUIMC的临床室内内部资助机制。 P/F获奖者将享受更多 将大大促进其研究的好处，包括生物医学核心补贴远远超出 资金持续时间；通过丰富纳入我们全面的学术指导计划 计划集成以及研究和教育中的CU-DLDRC活动，例如临床基础团队， 讲习班和研讨会。 P/F计划将通过三个 具体目的：征求和严格的同行评审申请，从而支持高度创新的研究 以及消化研究中的新星（AIM 1）；通过通过P/F资助的研究人员的成功来最大化 科学互动，教育，培训和指导以及CU-DLDRC核心补贴的机会 （目标2）;并通过长期跟踪获奖者来高效监督P/F计划成果 出版物和赠款（目标3）。我们预计P/F计划将增强高度多样性的发展 基本和临床人才，并促进创新的有影响力的科学超越当前消化 研究。通过 与丰富计划，其DEI代表和哥伦比亚的广泛资源合作。 我们已经取得了最初的成功，利用Cu-dldrc以及机构的合作和资源。