Characterization of hippocampal sclerosis in individuals with calcified Neurocysticercosis

钙化神经囊尾蚴病个体海马硬化的特征

• 批准号: 9181363
• 负责人: Hector Hugo Garcia
• 金额: $ 21.75万
• 依托单位: UNIVERSIDAD PERUANA CAYETANO HEREDIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9181363
• 关键词: Antigens; Atrophic; Bilateral; Brain; Calcified; Cerebrum; Characteristics; Chronic; Clinical; Collaborations; Control Groups; Cysticercosis; Developed Countries; Developing Countries; Diffuse; Ecuador; Electroencephalography; Epilepsy; Epileptogenesis; Focal Seizure; Frequencies; Future; General Population; Goals; Health; Hippocampus (Brain); Human; Individual; Infection; Inflammatory; Intervention; Intractable Epilepsy; Larva; Latino; Lesion; Location; Magnetic Resonance Imaging; Measures; Modeling; Neurocysticercosis; Parasites; Participant; Pathology; Patients; Pattern; Perinatal Brain Injury; Peru; Prevalence; Recording of previous events; Refractory; Research Design; Risk Factors; Seizures; Site; Spinal; Suggestion; Taenia solium; Temporal Lobe Epilepsy; Thick; Time; Traumatic Brain Injury; Visual; Work; calcification; cohort; computational morphometry; hippocampal sclerosis; morphometry; neocortical; nervous system infection; neuroimaging; neurophysiology; patient population; population based; working group

Characterization of Hippocampal Sclerosis in Individuals With Calcified Neurocysticercosis ABSTRACT Most of the global burden of epilepsy occurs in poor regions of the world, reflecting increased prevalence of risk factors such as perinatal brain damage, traumatic brain injury, and infections of the nervous system including neurocysticercosis (NCC). NCC is endemic in most developing countries, and the prevalence of seizures and epilepsy is consistently increased in individuals with NCC when compared to the general population. Epilepsy is more prevalent in cysticercosis-endemic regions, and cases of chronic focal seizures semiologically related to the localization of a parasitic lesion are frequent. Perhaps more interestingly, information from patients with refractory epilepsy and NCC suggests that in some patients parasites might be involved in epileptogenesis by inducing hippocampal damage, which can become the site of seizure onset. We propose to take advantage of an existing cohort of 228 patients with calcified cerebral cysticercosis lesions as well as 50 control patients with spinal pathologies without cerebral involvement, to demonstrate the association between NCC and hippocampal sclerosis, and to characterize the clinical, neurophysiological, and neuroimaging characteristics associated with hippocampal sclerosis in these individuals. Participants will have hippocampal assessment by non-contrasted brain MRI, and computational morphometry analysis of MRI will be used to characterize specific neocortical and subcortical patterns of atrophy (with the use of volumetric MRI and cortical thickness measures) and to determine whether HS in these patients has the specific pattern of CA2 sparing found in mesial temporal lobe epilepsy or another, non-specific pattern. EEG and Video EEG will be performed to determine whether the location of the epileptogenic region correlates with the location of the HS or a calcified lesion elsewhere. The frequencies of all factors potentially associated with HS (including but not restricted to time with seizures, cumulative number of previous seizures, type of seizures, number and localization of brain calcifications, and EEG abnormalities) will be compared between individuals with and without HS. If NCC-associated HS is the epileptogenic region, and is similar to the HS in MTLE it would provide an opportunity to study epileptogenesis clinically for the most common form of intractable epilepsy.

钙化神经囊肿的个体海马硬化的表征 抽象的 全球癫痫的大部分负担发生在世界贫困地区，反映 诸如围产期脑损伤，脑外伤和神经系统感染等危险因素 包括神经囊肿（NCC）。 NCC在大多数发展中国家是地方性的，并且 与一般相比，NCC的个体的癫痫发作和癫痫始终增加 人口。癫痫在囊肿 - 流行区域和慢性局灶性癫痫病例中更为普遍 与寄生病变的定位在半学上相关。也许更有趣的是 难治性癫痫患者和NCC患者的信息表明，在某些患者中，寄生虫可能是 通过诱导海马损伤参与癫痫发生，这可能成为癫痫发作的部位。我们 提议利用现有的228例钙化脑囊肿性病变患者的队列 以及50例无脑介入的脊柱病理的患者，以证明该关联 在NCC和海马硬化症之间，并表征临床，神经生理学和 这些个体中与海马硬化有关的神经影像特征。参与者会有 通过非对抗的脑MRI评估海马评估，MRI的计算形态计算分析将 用于表征萎缩的特定新皮质和皮质下模式（使用体积MRI 和皮质厚度措施），并确定这些患者中的HS是否具有特定模式 Ca2在中腔颞叶癫痫或另一种非特异性模式中发现。脑电图和视频脑电图将 进行以确定癫痫发作区域的位置是否与 HS或其他地方的钙化病变。所有可能与HS相关的因素的频率（包括 不限于癫痫发作，先前癫痫发作的累积数量，癫痫发作类型，数字和 将比较有和 没有HS。如果与NCC相关的HS是癫痫病区域，并且与MTLE中的HS相似 提供了一个机会，可以在临床上研究癫痫发生的最常见形式的顽固性癫痫。