Population Assessment of Alzheimer's and Related Dementias in Rural Northern Peru

秘鲁北部农村地区阿尔茨海默病和相关痴呆症的人口评估

• 批准号: 9817141
• 负责人: Hector Hugo Garcia
• 金额: $ 16.3万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9817141
• 关键词: Adult; Age-Years; Aliquot; Alzheimer' s Disease; Alzheimer' s disease related dementia; Biological Markers; Blood; Central Nervous System Infections; Clinical Research; Cognition; Cognitive; Cohort Studies; Collaborations; Communities; Consensus; Consent; Country; Data; Dementia; Development; Diabetes Mellitus; Epilepsy; Exhibits; Funding; Future; Goals; Grant; Hypertension; Impaired cognition; Incidence Study; Income; Individual; Inflammatory; Intervention; Latin America; Latin American; Longitudinal Studies; Low income; Metabolic; Metabolic syndrome; Metabolism; Nested Case-Control Study; Neurologic; Participant; Pathogenesis; Peru; Peruvian; Population; Population Research; Population Study; Prevalence; Prevention; Quality of life; Research; Research Personnel; Risk Factors; Rivers; Running; Rural; Rural Community; Rural Population; Sampling; Sleep; Standardization; Structure; Surveys; Symptoms; Teniasis; Time; Urine; biobank; cardiovascular health; cardiovascular risk factor; cognitive performance; cognitive testing; cohort; community planning; dementia risk; demographics; design; disability; edentulism; experience; global health; high risk; illiteracy; low and middle-income countries; meetings; member; modifiable risk; neuroimaging; novel; novel marker; population based; population health; prevent; programs; repository; symposium; therapeutic target; tool; willingness

The overarching goal of this proposed R21 application is to better understand cognitive impairment and dementia in the LMIC setting of Tumbes, Peru through establishing a baseline of cognitive status for population-based studies of cognitive impairment and dementia in rural communities. Fifty-nine communities in this region have participated in prior research conducted by co-investigators on this application. To attain this goal, we propose the following specific aims: AIM 1: Define the spectrum, type and prevalence of cognitive impairment in Peruvians 60 years of age or older living in rural Northern Peru; AIM 2a: Initiate a population-based cohort of adults with and without cognitive impairment in rural Latin America to facilitate future longitudinal studies of incidence and prevention of cognitive decline and dementia; and Aim 2b: Establish a biomarker and biobanking core, containing information and samples from a large rural population-based cohort of Latin American adults with varying levels of cognitive impairment. This proposal would establish a new collaboration for population-based and clinical research in cognitive impairment, dementia and Alzheimer's disease in a well-established research population in northern Peru with a team of highly experienced investigators in dementia and population health. Although the research tools proposed for this study are well known, they would provide novel information regarding the prevalence of dementia and risk factors for cognitive impairment and dementia at a population-level in a unique rural Latin American population of Northern Peru. We will establish a novel biomarker core in this region with exciting opportunities for future studies of cognitive decline and dementia. Identification of modifiable risk factors could provide therapeutic targets and future opportunities to better understand the influence of metabolism upon cognition over time. In addition, through obtaining information regarding disabilities and quality of life, we will be able to better characterize the impact of cognitive impairment and dementia upon rural Latin American communities - information that currently is not available.

该提议的R21应用的总体目标是更好地了解认知障碍和痴呆症 在Tumbes的LMIC环境中，秘鲁通过建立基于人群的认知状况的基准 农村社区认知障碍和痴呆症的研究。该地区的五十九个社区有 参与了共同评估者对此应用的先前研究。为了实现这一目标，我们建议 以下具体目的：目标1：定义秘鲁人认知障碍的频谱，类型和流行率 居住在秘鲁北部农村的60岁或以上； AIM 2A：启动基于人群的成年人队列 并且没有在拉丁美洲农村的认知障碍，以促进未来的发病率研究和 预防认知能力下降和痴呆；和目标2b：建立一个生物标志物和生物库核心，其中包含 来自大型农村人口的拉丁美洲成年人队列的信息和样本，水平不同 认知障碍。该建议将建立针对基于人群和临床的新合作 认知障碍，痴呆症和阿尔茨海默氏病的研究在公认的研究人群中 在北部秘鲁，有一支经验丰富的痴呆症和人口健康调查员团队。虽然 该研究提出的研究工具是众所周知的，他们将提供有关有关的新信息 痴呆症的患病率和认知障碍和痴呆症的危险因素在人群级别的独特之处 北部北部的拉丁美洲人口。我们将在该地区建立一个新颖的生物标志物核心 未来研究认知能力下降和痴呆症的激动人心的机会。识别可修改风险因素 可以提供治疗目标和未来的机会，以更好地了解代谢对 认知随着时间的流逝。此外，通过获取有关残疾和生活质量的信息，我们将 能够更好地表征认知障碍和痴呆对农村拉丁美洲的影响 社区 - 目前尚无可用的信息。