Improving Diagnostic and Management Tools for Neurocysticercosis (Peru-JHU TMRC Program)

改进神经囊尾蚴病的诊断和管理工具（秘鲁-JHU TMRC 计划）

• 批准号: 9913450
• 负责人: Hector Hugo Garcia
• 金额: $ 53.61万
• 依托单位: UNIVERSIDAD PERUANA CAYETANO HEREDIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913450
• 关键词: Animal Model; Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Biological Markers; Biostatistics Core; Brain; Brain Injuries; Cessation of life; Clinical Trials; Code; Cyst; Cysticercosis; Development; Diagnosis; Diagnostic; Diagnostic tests; Early Diagnosis; Encephalitis; Endemic Diseases; Enhancing Lesion; Ensure; Epilepsy; Ethics; Foundations; Frequencies; General Population; Human; In Vitro; Individual; Inflammation; International; Libraries; Modeling; Molecular Biology Techniques; Monitor; Morbidity - disease rate; Neurocysticercosis; Parasites; Peru; Peruvian; Predictive Value; Principal Investigator; Process; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scheme; Secondary to; Seizures; Sensitivity and Specificity; Solid; Taenia solium; Technology; Testing; Translating; Treatment Efficacy; Work; animal care; data management; diagnostic assay; genomic data; improved; in vitro Model; nanoparticle; novel diagnostics; programs; screening; tool

Improving Diagnostic and Management Tools for Human Cysticercosis / Perú-JHU TMRC PROGRAM OVERVIEW Principal Investigator / Program Director (last, middle, first): GARCIA, Héctor H. Improving Diagnostic and Management Tools for Neurocysticercosis (Perú-JHU TMRC Program) PROJECT SUMMARY Taenia solium neurocysticercosis continues to be a major cause of seizures and epilepsy in most of the world. Our group has continuously worked in NCC for the last 25 years and has provided landmark contributions to its study, diagnosis, and treatment. This TMRC application builds on a recent ICIDR application and uses resources developed and acquired over this period including sample libraries, in vitro and animal models (including three new models recently developed in our settings) and recently available nanoparticle diagnostics and genomic data. Our objective is to provide improved diagnostics and monitoring as well as more efficient antiparasitic and antiinflammatory therapies in order to minimize brain damage which follows parasite death. Early diagnosis and improved treatment should result in reduced frequency of epilepsy secondary to NCC. The Perú-JHU TMRC application frames three component Research Projects and three Cores to provide a fully functional research network and take advantage of the endemicity of the disease and our existing, highly successful research network in Perú. The scientific core will serve as the foundation to be used by the two research projects, and will include capacities for in vitro and animal models, molecular biology techniques, and analytic processes, and will be supported by the Data Management and Biostatistics Core. An Administrative Core including Ethics and Animal Care units will ensure full compliance with local and international research codes and regulations. Three projects comprise the program: The three research projects are Component 1 - Improved Diagnostics Assays for Viable or Degenerating Neurocysticercosis; Component 2 - Biomarkers for Monitoring Treatment Efficacy in Human Neurocysticercosis, and Component 3 - Improving the Understanding and Treatment of Brain Inflammation in Neurocysticercosis. The Program will take advantage of the specific objectives of these research projects to provide a unified set of promising tools ready to be tested in clinical trials and translated to human use.

改善人类囊肿的诊断和管理工具 /佩鲁-JHU TMRC计划概述 首席调查员 /计划总监（最后，中，第一）：加西亚，HéctorH。 改善神经囊肿的诊断和管理工具 （Perú-Jhu TMRC计划） 项目摘要 在大多数 世界。在过去的25年中，我们的小组一直在NCC不断工作，并提供了地标 对其研究，诊断和治疗的贡献。此TMRC应用程序建立在最近的ICIDR上 应用和使用此期间开发和获取的资源，包括样本库，体外 和动物模型（包括最近在我们的设置中开发的三个新型号），最近可用 纳米颗粒诊断和基因组数据。我们的目标是提供改进的诊断和监测 以及更有效的抗寄生虫和抗炎疗法，以最大程度地减少脑损伤 寄生虫死亡。早期诊断和改善治疗应导致频率降低 继发于NCC的癫痫。 秘密jhu tmrc应用程序将三个组件研究项目和三个核心框架构架 提供功能齐全的研究网络，并利用疾病的内在性和我们 现有的，非常成功的研究网络。科学核心将作为基础 两个研究项目使用，并将包括体外和动物模型的能力，分子 生物学技术和分析过程，并将得到数据管理和 生物统计学核心。包括道德和动物护理部门在内的行政核心将确保完全合规 与本地和国际研究法规有关。三个项目包括该计划： 这三个研究项目是1-改进可行或可行的诊断测定法 退化神经囊肿；组件2-用于监测人类治疗功效的生物标志物 神经囊肿和成分3-改善对脑炎症的理解和治疗 在神经囊肿中。该计划将利用这些研究项目的具体目标 提供一组统一的承诺工具，准备在临床试验中进行测试并转化为人类使用。