PILOT/EXPLORATORY STUDIES CORE

试点/探索性研究核心

基本信息

批准号：
8688860
负责人：
ANDREW P GOLDBERG
金额：
$ 21.84万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8688860
关键词：
Adherence Advisory Committees Aerobic Exercise Aging American Applications Grants Award Blood Vessels Cancer Survivor Chronic Chronic Disease Clinical Clinical Trials Collaborations Community Practice Data Development Disabled Persons Discipline Elderly Electroencephalography Enrollment Ensure Environment Ethics Exercise Extramural Activities Faculty Fatigue Funding Future Gait Goals Grant Health Hip Fractures Human Individual Inflammation Instruction Interdisciplinary Study Intervention Leadership Life Style Maintenance Maps Maryland Mentors Mentorship Metabolic syndrome Metabolism Mission Monitor Muscle Muscle function Neuropsychology Non-Insulin-Dependent Diabetes Mellitus Peer Review Physiology Pilot Projects Prevention Preventive Medicine Privacy Process Productivity Proteins Publications Recording of previous events Recovery Regulation Rehabilitation Outcome Rehabilitation Research Rehabilitation therapy Research Research Personnel Resources Safety Simulate Stem cells Stroke Supplementation Survivors Training Translating Universities Vitamin D Walking Work base density design disability disabling disease functional decline functional disability glucose metabolism human subject protection improved innovation interdisciplinary collaboration malignant breast neoplasm meetings motor learning multidisciplinary novel prevent programs rehabilitation science relating to nervous system research study response restoration strength training success translational approach treadmill training working group

项目摘要

The goal of the Pilot/Exploratory Studies Core (PESC) is to promote innovative multidisciplinary research focused on the mechanisms underlying disability, recovery and prevention in older persons and the functional and clinical responses to rehabilitation. The PESC manages the process of promotion, application, review, award and monitoring for Pilot and Exploratory Studies (PES). Priorities for awards include relevance to the OAIC theme, potential for independent funding, new multidisciplinary collaboration and translational potential. The priori 5-year history of outstanding research productivity and academic accomplishments of pilot investigators attests to our excellent environment, mentors and academic resources in support of PES. This OAIC has made 58 pilot grant awards since its inception in 1994. Success of PESC is demonstrated by the 23 pilots funded in the 2000-2005 OAIC for $460,000 that have yielded over $2.8 million in extramural funding. During the last 5 years, PESC invested $371,000 in 16 pilot studies that have to date generated 25 publications and ~ $2.9 million in extramural funding. PESC funding and mentorship of junior faculty and others in the conduct of PES's is essential to improve the rehabilitation outcomes and recovery of older people with chronic disabling diseases and advance the field of exercisebased rehabilitation with new academic leaders. Proposed first year pilot studies include PES-1: Improving walking symmetry and functional mobility in stroke survivors with split-belt treadmill training; PES-2: Aerobic exercise to improve regulation of EPCs and vascular function in T2DM; PES-3: Effects of Vitamin D Repletion (D) with and without Multicomponent Lifestyle Exercise Training (MLife) on Muscle Function, Inflammation and Glucose Metabolism in D Deficient OlderAdults; PES-4: Resistance Training (RT) and Protein (Pro) Supplementation to Improve Muscle Physiology and Reduce Fatigue in Breast Cancer Survivors; PES-5: A High-Density Electroencephalography (EEG) Neural Decoding Study of Dynamical Cortical Mapping of Gait in Humans After Stroke.

试点/探索性研究核心（PESC）的目标是促进创新的多学科研究，重点是老年人的残疾，康复和预防机制以及对康复的功能和临床反应。 PESC管理试点和探索性研究（PES）的促进，应用，审查，奖励和监测过程。奖项的优先事项包括与OAIC主题，独立资金的潜力，新的多学科合作和翻译潜力的相关性。杰出的研究生产力和试点研究人员的学术成就的五年历史证明了我们的出色环境，导师和学术支持PES的资源。自1994年成立以来，这项OAIC已获得了58个飞行员授予奖。 PESC的成功得到了2000 - 2005年OAIC资助的23名飞行员的成功，其460,000美元收益超过280万美元。在过去的5年中，PESC在16项试点研究中投资了371,000美元，这些研究迄今为止已经产生了25个出版物，造成了290万美元的校外资金。 PESC资金初级教师和其他人对PES进行的指导对于改善慢性残疾疾病的老年人的康复结果和恢复至关重要，并促进与新的学术领导者进行基于运动的康复领域。拟议的第一年试点研究包括PES-1：通过脱离皮带跑步机训练，改善中风幸存者中的步行对称性和功能流动性； PES-2：有氧运动以改善T2DM中EPC和血管功能的调节； PES-3：具有和不具有多组分生活方式运动训练（MLIFE）的维生素D补充（D）对D不足的老年人的肌肉功能，炎症和葡萄糖代谢的影响； PES-4：补充耐药性训练（RT）和蛋白质（Pro），以改善肌肉生理和减轻乳腺癌幸存者的疲劳； PES-5：中风后人类步态动力学皮质图的高密度脑电图（EEG）神经解码研究。