Epidemiology and Biostatisctics

流行病学和生物统计学

• 批准号: 8708445
• 负责人: Dennis M Black
• 金额: $ 15.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708445
• 关键词: Address; Basic Science; Biological; Biology; Biometry; Biostatistics Core; Clinical; Clinical Data; Clinical Research; Clinical/Radiologic; Collaborations; Communities; Consult; Consultations; Data; Data Analyses; Data Set; Degenerative polyarthritis; Diagnosis; Doctor of Philosophy; Education; Endocrinology; Epidemiology; Funding; Genetic; Genomics; Grant; Image; Joints; Medicine; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Orthopedic Surgery procedures; Osteoporosis; Pathogenesis; Persons; Pilot Projects; Radiology Specialty; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk Factors; Sampling; Scientist; Services; Source; Techniques; Testing; Training; Training Technics; Translational Research; United States National Institutes of Health; Woman; Work; bone; cost; design; longitudinal database; member; men

We propose an Epidemiology and Biostatistics Core that will make available to CCMBM investigators data from a large number of studies that are supported by NIAMS and other sources. These studies include clinical data, images, and biological samples on over 100,000 men and women followed for over 1,000,000 person years. The Core currently receives about $20,000,000 per year in total costs for bone and joint projects of which about 60% in from NIAMS. The EB Core would also provide consulting on study design and biostatistics and education of design and implementation of clinical research projects. The specific aims of the Core are as follows: 1). To make available to the UCSF osteoporosis and osteoarthritis research community large, longitudinal databases including associated biological and imaging data that will be used to test hypotheses and techniques regarding the pathogenesis, risk factors, and diagnosis of osteoporosis and osteoarthritis. 2). To train UCSF bone and joint researchers in good study design and execution practices to maximize the rigor and validity of their work. 3). To provide data analysis services and consultation for genetics and genomics data sets. 4). To provide to the CCMBM community at UCSF consulting in the design and analysis of NIH-funded projects and proposals as well as pilot studies funded by CCMBM. 5). To encourage stronger ties and to serve as a conduit for collaborations between basic, translational, and clinical research in bone and joints at UCSF. The Core will be Co-Directed by Dennis Black, PhD and Michael Nevitt, PhD, and will build on existing collaborations with CCMBM members, (e.g. radiology, orthopaedic surgery, and endocrinology) to design new studies that enhance the value of existing NIAMS fund resources. The proposed CCMBM will have high clinical impact by stimulating collaborations between basic and clinical scientists that would not otherwise exist. This is an exciting and unique opportunity to leverage the vast osteoporosis and osteoarthritis resources, at UCSF to address new questions and expand the bone and joint research community.

我们提出了一个流行病学和生物统计学核心，该核心将为CCMBM研究者提供数据 来自NIAMS和其他来源支持的大量研究。这些研究包括 超过100,000多名男女的临床数据，图像和生物样本超过100万 人年。目前的核心每年收到约20,000,000美元的骨头和联合成本 该项目大约有60％来自Niams。 EB核心还将提供有关研究设计的咨询 以及临床研究项目设计和实施的生物统计学和教育。具体目标 核心的内容如下：1）。为了向UCSF骨质疏松症和骨关节炎研究社区提供，大型纵向数据库，包括相关的生物学和成像数据，这些数据将用于检验假设和 有关骨质疏松和骨关节炎的发病机理，危险因素和诊断的技术。 2）。培训UCSF骨骼和联合研究人员，以良好的研究设计和执行实践来最大程度地提高其工作的严格性和有效性。 3）。为遗传学和基因组学数据集提供数据分析服务和咨询。 4）。在UCSF咨询公司的CCMBM社区中，在NIH资助的项目和建议以及CCMBM资助的试点研究方面提供了咨询。 5）。为了鼓励更牢固的联系并作为UCSF骨骼和关节基本，转化和临床研究之间合作的渠道。核心将由丹尼斯·布莱克（Dennis Black），博士和迈克尔·尼维特（Michael Nevitt）博士共同指导，并将基于与CCMBM成员（例如放射学，骨科外科和内分泌学）的现有合作，以设计新的研究，以增强现有NIAMS基金资源的价值。拟议的CCMBM将通过刺激基本科学家和临床科学家之间的合作，从而产生很大的临床影响，而这些临床将不存在。这是一个令人兴奋而独特的机会，可以利用巨大的骨质疏松和骨关节炎 在UCSF的资源，以解决新问题并扩大骨骼和联合研究社区。