Total Synthesis of Bioactive Natural Products

生物活性天然产物的全合成

• 批准号: 9054864
• 负责人: Richmond Sarpong
• 金额: $ 31.19万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9054864
• 关键词: Address; Alkaloids; Anabolism; Architecture; Biogenesis; Biological; Collaborations; Complex; Development; Family; Foundations; Goals; Grant; Health; Human; Indole Alkaloids; Intention; Laboratories; Lead; Malignant Neoplasms; Medicine; Methodology; Methods; Michigan; Molecular; Natural Products; Outcome; Pharmacologic Substance; Preparation; Proline; Pyrrolidines; Reporting; Research; Route; Staging; Time; Variant; anticancer activity; base; bioactive natural products; cancer therapy; chemical synthesis; combat; expectation; insight; interest; lycopodium alkaloid; member; novel; paraherquamide; piperidine; programs; pyridine; small molecule; stephacidin A

 DESCRIPTION (provided by applicant): The goal of this program is to develop new strategies for the synthesis of bioactive molecules in the prenylated indole alkaloid family. The complex natural products that we construct, and their unique derivatives which are only accessible using our strategies, will provide small molecules that will serve as a starting point to identify anticancer compounds that function via novel mechanisms. Our synthetic studies should also lead to insights into the biosynthesis of a subset of the prenylated indole alkaloids for which the biogenesis is not established. Specifically, we intend to develop strategies to synthesize different structural classes of prenylated indole alkaloids including the citrinalins, cyclopiamine, citrinadins and the stephacidins.

 描述（由适用提供）：该计划的目的是制定新的策略，以合成原型吲哚生物碱家族中生物活性分子。我们构建的复杂天然产物及其独特的衍生物只能使用我们的策略访问，它将提供小分子，这些分子将作为识别通过新机制起作用的抗癌化合物的起点。我们的合成研究也应导致对一部分的吲哚基生物碱子集的生物合成的见解。 未建立生物发生。具体而言，我们打算制定策略，以合成不同结构类别的吲哚吲哚生物碱的不同结构类别类别，包括瓜醇蛋白，环孢胺，瓜霉素和斯蒂芬蛋白。