Kansas PKD Research and Translation Core Center

堪萨斯 PKD 研究与翻译核心中心

基本信息

批准号：
9264648
负责人：
JAMES P CALVET
金额：
$ 4.43万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9264648
关键词：
Affect Aortic Aneurysm Automobile Driving Basic Science Biochemistry Biological Markers Biomedical Research Blood Cardiovascular system Caring Cell Culture Techniques Cell physiology Cells Cellular biology Cerebral Aneurysm Clinical Clinical Research Clinical Trials Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Cyclic AMP Cyst Data Databases Defect Development Dialysis procedure Disease Disease Pathway Educational process of instructing Effectiveness Environment Epigenetic Process Evaluation Fluids and Secretions Foundations Gene Targeting Genes Goals Grant Growth Heart Valves High Prevalence Human Resources Hypertension Inherited Institution Interdisciplinary Study Intracellular Second Messenger Investigation Kansas Kidney Kidney Failure Liquid substance Medical center Mission Morbidity - disease rate Observational Study Pathogenesis Pathway interactions Patient-Focused Outcomes Patients Pharmaceutical Preparations Physicians Physiology Polycystic Kidney Diseases Population Process Public Health Reagent Recording of previous events Renal tubule structure Research Research Infrastructure Research Personnel Research Project Grants Resource Sharing Resources Role Sampling Scientist Second Messenger Systems Serum Services Signal Pathway Signaling Protein Site Staging Technology Testing Therapeutic Training Translational Research Transplantation United States National Institutes of Health Universities Urine base cohort cost drug development early childhood epigenetic marker exosome follow-up improved in vivo innovation insight meetings mortality multidisciplinary new technology novel novel therapeutics patient oriented patient registry programs repository research and development specific biomarkers success symposium targeted treatment therapy development tolvaptan tool transcription activator-like effector nucleases translational medicine urinary user-friendly

项目摘要

DESCRIPTION (provided by applicant): The Kansas PKD Research and Translation Core Center (Director: James Calvet) is comprised of an Administrative Core, Pilot & Feasibility Program, Educational Enrichment Program, and four Biomedical Research Cores: Gene Targeting, Epigenetics, Biomarkers, and Clinical Research. At its foundation, the Center has an active and growing research base of outstanding PKD investigators on which it proposes to build innovative cores and a robust P&F program providing opportunities for new investigators to enter the PKD field and to conduct cutting-edge research. The mission of the PKD Center is "The promotion of research leading to a better understanding of polycystic kidney disease and the discovery of targets for therapy and development of clinical trials ultimately for improved patient outcomes." The central theme of this proposal is "Target identification for PKD therapy development." The Kansas PKD Research and Translation Core Center will achieve the broad goals and objectives articulated by the center's mission and central theme by accomplishing these four specific aims: 1) To support PKD researchers locally and nationally by developing innovative biomedical research cores. 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical research investigator base. 3) To develop partnerships within the institution, with shared support facilities, and with cooperating institutions. 4) To enhance the research environment to support ongoing projects and to develop new research directions.

描述（由应用程序提供）：堪萨斯州PKD研究与翻译核心中心（主任：James Calvet）完成了行政核心，飞行员和可行性计划，教育丰富计划和四个生物医学研究核心：基因靶向，表观遗传学，生物标志物，生物标志物和临床研究。该中心在其基础上拥有一个积极且不断增长的研究基础，其中包括杰出的PKD调查人员，它提议建立创新的核心和强大的P＆F计划，为新研究人员提供了进入PKD领域并进行尖端研究的机会。 PKD中心的任务是“促进研究，从而更好地了解多囊性肾脏疾病，并发现最终用于改善患者结果的临床试验的治疗和开发目标。”该提案的中心主题是“ PKD疗法开发的目标识别”。堪萨斯州PKD研究和翻译核心中心将通过完成这四个具体目标来实现由中心的使命和中心主题所阐明的广泛目标：1）通过开发创新的生物医学研究核心来支持本地和全国范围内的PKD研究人员。 2）开发一个熟练的，合作的，多学科的基础科学和临床研究研究者基础。 3）在机构内建立合作伙伴关系，并通过共享的支持设施以及与合作机构建立合作伙伴关系。 4）增强研究环境，以支持正在进行的项目并开发新的研究方向。