Kansas PKD Research and Translation Core Center

堪萨斯 PKD 研究与翻译核心中心

• 批准号: 10059764
• 负责人: JAMES P CALVET
• 金额: $ 90.57万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10059764
• 关键词: Autosomal Dominant Polycystic Kidney; Basic Science; Biochemistry; Biocompatible Materials; Biological Markers; Biomedical Research; Cancer Center; Cell model; Cell physiology; Cellular biology; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Cyst; Development; Disease; Drug Targeting; Educational workshop; Effectiveness; Environment; Foundations; Goals; Grant; Growth; Infrastructure; Institutes; Institution; Interdisciplinary Study; Kansas; Kidney; Medical center; Methods; Mission; Pathogenesis; Patient-Focused Outcomes; Patients; Polycystic Kidney Diseases; Reagent; Recording of previous events; Research; Research Methodology; Research Personnel; Research Support; Resource Sharing; Resources; Rodent Model; Series; Services; Site; Technology; Testing; Translations; Universities; base; biomarker discovery; clinical development; drug testing; educational atmosphere; improved; innovation; insight; inter-institutional; meetings; multidisciplinary; new technology; novel therapeutic intervention; novel therapeutics; patient oriented; programs; recruit; summer student; symposium; therapeutic target; tool; translational medicine

Project Summary – Overall The Kansas PKD Research and Translation Core Center (RTCC) is comprised of an Administrative Core and three innovative Biomedical Research Cores: Core 1: Biomarkers, Biomaterials, and Cellular Models; Core 2: Rodent Models & Drug Testing; and Core 3: Clinical Research. The Kansas RTCC also offers an Educational Enrichment Program and an internal Pilot Grant Program in partnership with the KU Cancer Center. The mission of the PKD Center is to promote PKD research by providing both innovative and essential reagents, biomaterials, and service to the national PKD research community for the advancement of our understanding of disease mechanisms, the discovery of biomarkers and therapeutic targets and the development of clinical trials to improve patient outcomes. The Specific Aims of the Kansas PKD RTCC are: Aim 1) To support PKD researchers nationally by developing innovative biomedical research cores. This will be accomplished by developing the expertise, reagents and resources required to bring the best new technologies to PKD research to meet the needs of the greater PKD research community; by leveraging existing institutional shared resources to expand our capability, efficiency, and effectiveness; and by developing tools to support clinical research and establish collaborations both regionally and nationally to develop a multi-institutional ADPKD clinical trials network. Aim 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical PKD research investigator base. This will be accomplished by building on our broad multidisciplinary research base and continuing to recruit new investigators from outside the PKD field by offering an innovative pilot grant program that will attract new investigators to the field, and by providing new investigators, nationally, with research support for core services, new technologies, educational opportunities, and an open and collaborative research environment that will help them succeed. Aim 3) To enhance the PKD research environment with educational programs to support ongoing projects and to develop new research directions. The research environment will be enhanced through a seminar program, Summer Student Enrichment Program, PKD lab meetings, PKD methods workshops, Research Methods and Advanced Technologies Program, professional development seminar series, patient-oriented activities, and by participating in the consortium-wide annual symposium. Aim 4) To develop partnerships regionally and nationally and to build teams to serve as a resource for the greater PKD research community. Inter-institutional partnerships will provide local and national infrastructure support, new research technologies, increased numbers of patients involved in clinical trials, and research collaborators for the development of new research opportunities by attracting investigators from other fields into PKD research from collaborating sites within the PKD Research Consortium and with cooperating institutions nationwide, broadening opportunities beyond what any single institution can provide.

项目摘要 - 总体 堪萨斯州PKD研究与翻译核心中心（RTCC）完成了行政核心， 三个创新的生物医学研究核心：核心1：生物标志物，生物材料和细胞模型；核心2： 啮齿动物模型和药物测试；和核心3：临床研究。堪萨斯州RTCC还提供教育 与KU癌症中心合作的丰富计划和内部试点赠款计划。这 PKD中心的使命是通过提供创新和基本试剂来促进PKD研究， 生物材料和为国家PKD研究界的服务，以提高我们的理解 疾病机制，生物标志物和治疗靶标的发现以及临床的发展 试验以改善患者预后。堪萨斯州PKD RTCC的具体目的是：目标1）支持PKD 通过开发创新的生物医学研究核心，全国研究人员。这将通过 开发将最佳新技术带入PKD研究所需的专业知识，试剂和资源 满足大型PKD研究社区的需求；通过利用现有的机构共享 扩大我们的能力，效率和有效性的资源；并开发支持临床的工具 研究并在区域和全国建立合作，以开发多机构的ADPKD 临床试验网络。目标2）开发熟练的，协作的，多学科的基础科学和临床 PKD研究调查员基础。这将通过我们的广泛的多学科研究来实现 基地并继续通过提供创新的飞行员赠款来从PKD领域招募新的调查员 将吸引新调查人员进入该领域的计划，并通过在全国范围内提供新的调查人员 研究核心服务，新技术，教育机会以及开放与协作的研究支持 将帮助他们成功的研究环境。目标3）用 教育计划，以支持正在进行的项目并开发新的研究方向。研究 通过开创性计划，夏季学生丰富计划，PKD实验室，将增强环境 会议，PKD方法研讨会，研究方法和高级技术计划，专业 开发节目系列，面向患者的活动，并参加整个财团的年度 座谈会。目标4）在区域和全国建立伙伴关系，并建立团队作为一个 大PKD研究社区的资源。机构间合作伙伴关系将提供地方和国家 基础设施支持，新的研究技术，参与临床试验的患者数量增加以及 通过吸引其他其他研究人员的研究人员的研究合作者 从PKD研究联盟内的协作站点和合作的领域进行PKD研究 在全国范围内的机构，扩大了任何单个机构所能提供的机会。