Kansas PKD Research and Translation Core Center

堪萨斯 PKD 研究与翻译核心中心

基本信息

批准号：
9754118
负责人：
JAMES P CALVET
金额：
$ 107.53万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-07-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9754118
关键词：
Affect Aortic Aneurysm Automobile Driving Basic Science Biochemistry Biological Markers Biomedical Research Blood Cardiovascular system Caring Cell Culture Techniques Cell physiology Cells Cellular biology Cerebral Aneurysm Clinical Clinical Research Clinical Trials Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Consultations Cyclic AMP Cyst Data Databases Defect Development Dialysis procedure Disease Disease Pathway Drug Targeting Educational process of instructing Effectiveness Environment Epigenetic Process Evaluation Fluids and Secretions Foundations Gene Targeting Genes Goals Grant Growth Heart Valves Hereditary Disease High Prevalence Human Resources Hypertension Infrastructure Institution Interdisciplinary Study Investigation Kansas Kidney Kidney Failure Liquid substance Longterm Follow-up Medical center Mission Morbidity - disease rate Observational Study Pathogenesis Pathway interactions Patient-Focused Outcomes Patients Pharmaceutical Preparations Physicians Physiology Polycystic Kidney Diseases Population Process Proteins Reagent Recording of previous events Renal tubule structure Research Research Personnel Research Project Grants Resource Sharing Resources Role Sampling Scientist Second Messenger Systems Serum Services Signal Pathway Signal Transduction Site Technology Testing Therapeutic Training Translational Research Translations Transplantation United States National Institutes of Health Universities Urine base clinical development cohort cost drug development early childhood epigenetic marker exosome improved in vivo innovation insight meetings mortality multidisciplinary new technology new therapeutic target novel novel therapeutics patient oriented patient/disease registry programs repository research and development specific biomarkers success symposium targeted treatment therapy development tolvaptan tool transcription activator-like effector nucleases translational medicine urinary user-friendly

项目摘要

DESCRIPTION (provided by applicant): The Kansas PKD Research and Translation Core Center (Director: James Calvet) is comprised of an Administrative Core, Pilot & Feasibility Program, Educational Enrichment Program, and four Biomedical Research Cores: Gene Targeting, Epigenetics, Biomarkers, and Clinical Research. At its foundation, the Center has an active and growing research base of outstanding PKD investigators on which it proposes to build innovative cores and a robust P&F program providing opportunities for new investigators to enter the PKD field and to conduct cutting-edge research. The mission of the PKD Center is "The promotion of research leading to a better understanding of polycystic kidney disease and the discovery of targets for therapy and development of clinical trials ultimately for improved patient outcomes." The central theme of this proposal is "Target identification for PKD therapy development." The Kansas PKD Research and Translation Core Center will achieve the broad goals and objectives articulated by the center's mission and central theme by accomplishing these four specific aims: 1) To support PKD researchers locally and nationally by developing innovative biomedical research cores. 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical research investigator base. 3) To develop partnerships within the institution, with shared support facilities, and with cooperating institutions. 4) To enhance the research environment to support ongoing projects and to develop new research directions.

描述（由申请人提供）：堪萨斯 PKD 研究和翻译核心中心（主任：James Calvet）由行政核心、试点和可行性计划、教育丰富计划和四个生物医学研究核心组成：基因靶向、表观遗传学、生物标志物、和临床研究。成立之初，该中心拥有一个由优秀 PKD 研究人员组成的活跃且不断增长的研究基地，并建议在此基础上建立创新核心和强大的 P&F 计划，为新研究人员进入 PKD 领域并进行前沿研究提供机会。 PKD 中心的使命是“促进研究，以更好地了解多囊肾病并发现治疗靶点和开发临床试验，最终改善患者的治疗结果。”该提案的中心主题是“PKD 疗法开发的目标确定”。堪萨斯 PKD 研究和翻译核心中心将通过实现以下四个具体目标来实现该中心的使命和中心主题所阐明的广泛目标和目标： 1) 通过开发创新的生物医学研究核心来支持本地和全国的 PKD 研究人员。 2）发展技术精湛、协作性强、多学科的基础科学和临床研究研究者基地。 3) 在机构内部发展伙伴关系，共享支持设施，并与合作机构建立伙伴关系。 4) 改善研究环境以支持正在进行的项目并开发新的研究方向。