UT-Houston Regional Stroke Center

UT-休斯顿地区中风中心

基本信息

批准号：
9122511
负责人：
Sean I Savitz
金额：
$ 38万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9122511
关键词：
Adult Agreement Alteplase Area Attention Behavior Brain hemorrhage Clinical Trials Collaborations Communication Conduct Clinical Trials Development Emergency medical service Enrollment Ethics Fire - disasters Funding Health Lead Leadership Link Louisiana Minority Recruitment National Institute of Neurological Disorders and Stroke Nicardipine Patients Performance Physician Executives Physicians Pilot Projects Principal Investigator Randomized Recording of previous events Research Scientist Site South Texas Stroke Stroke prevention System Testing Training Training Programs United States National Institutes of Health Woman acute stroke base bench to bedside career clinical research site design disability efficacy trial ethnic diversity experience gulf coast high standard medical schools multidisciplinary neuroprotection novel novel marker pediatric patients prevent programs stroke recovery stroke therapy stroke treatment

项目摘要

DESCRIPTION (provided by applicant): Our center for 25 years has been a leader in clinical trials testing new treatments for stroke and brain hemorrhage. In this application, we aim to serve as a leading regional stroke coordinating center in the NINDS clinical trials stroke network and have assembled a well-organized group of connected clinical sites linked by a history of productive collaboration and led by a multidisciplinary and ethnically diverse team. In Specific Aim 1, we intend to lead a regional stroke coordinating center (RCC) consisting of multidisciplinary teams to conduct clinical trials testing novel stroke therapies in acute stroke, stroke prevention, and stroke recovery. The UT-Houston RCC will conduct clinical trials within a network of inter-connected sites in the greater Houston area, San Antonio, and New Orleans involving both adult and pediatric patients with attention to the recruitment of minorities and women. In specific Aim 2, we will provide expertise and leadership for the design of novel trials and propose trials testing new stroke therapies in acute stroke, stroke prevention, and stroke recovery. We will also provide translational expertise for the development of new stroke therapies from bench to bedside and for the development and testing of novel biomarkers. In specific Aim 3, we will establish a training program within our network for clinician-scientists wih high potential for independent research careers in stroke.

描述（由申请人提供）：我们的中心已有25年了，一直是临床试验测试中风和脑出血的新疗法的领导者。在此应用程序中，我们旨在在Ninds临床试验中风网络中充当领先的区域中风协调中心，并组建了一个组织良好的连接临床站点组，该临床站点由生产性合作的历史相关，并由多学科和种族多元化的团队领导。在特定目标1中，我们打算领导由多学科团队组成的区域中风协调中心（RCC），以进行临床试验，测试急性中风，预防中风和中风恢复中新型中风疗法。 UT-Houston RCC将在大休斯顿地区，圣安东尼奥市和新奥尔良的相互连接地点网络中进行临床试验，并涉及成人和儿科患者，并关注少数民族和妇女的招募。在特定目标2中，我们将为设计新颖的试验设计提供专业知识和领导能力，并提出试验测试急性中风，预防和中风恢复中的新中风疗法。我们还将提供转化专业知识，以开发从长凳到床边的新中风疗法以及开发和测试新型生物标志物。在特定的目标3中，我们将在我们的临床医生网络中建立一个培训计划，以实现中风独立研究职业的高潜力。