UT-Houston Regional Stroke Center

UT-休斯顿地区中风中心

基本信息

批准号：
8890903
负责人：
Sean I Savitz
金额：
$ 33.93万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8890903
关键词：
Adult Agreement Alteplase Area Attention Behavior Biological Markers Brain hemorrhage Clinical Trials Collaborations Communication Conduct Clinical Trials Development Emergency medical service Enrollment Ethics Fire - disasters Funding Health Lead Leadership Link Louisiana Minority National Institute of Neurological Disorders and Stroke Nicardipine Patients Performance Physician Executives Physicians Pilot Projects Principal Investigator Randomized Recording of previous events Research Scientist Site South Texas Stroke Stroke prevention System Testing Training Training Programs United States National Institutes of Health Woman acute stroke base bench to bedside career clinical research site design disability efficacy trial experience gulf coast high standard medical schools multidisciplinary neuroprotection novel pediatric patients prevent programs stroke recovery stroke therapy

项目摘要

DESCRIPTION (provided by applicant): Our center for 25 years has been a leader in clinical trials testing new treatments for stroke and brain hemorrhage. In this application, we aim to serve as a leading regional stroke coordinating center in the NINDS clinical trials stroke network and have assembled a well-organized group of connected clinical sites linked by a history of productive collaboration and led by a multidisciplinary and ethnically diverse team. In Specific Aim 1, we intend to lead a regional stroke coordinating center (RCC) consisting of multidisciplinary teams to conduct clinical trials testing novel stroke therapies in acute stroke, stroke prevention, and stroke recovery. The UT-Houston RCC will conduct clinical trials within a network of inter-connected sites in the greater Houston area, San Antonio, and New Orleans involving both adult and pediatric patients with attention to the recruitment of minorities and women. In specific Aim 2, we will provide expertise and leadership for the design of novel trials and propose trials testing new stroke therapies in acute stroke, stroke prevention, and stroke recovery. We will also provide translational expertise for the development of new stroke therapies from bench to bedside and for the development and testing of novel biomarkers. In specific Aim 3, we will establish a training program within our network for clinician-scientists wih high potential for independent research careers in stroke.

描述（由申请人提供）：25 年来，我们的中心一直在测试中风和脑出血新疗法的临床试验方面处于领先地位。在此应用中，我们的目标是成为 NINDS 临床试验卒中网络中领先的区域卒中协调中心，并组建了一组组织良好的相互关联的临床站点，这些站点通过富有成效的合作历史联系在一起，并由多学科和种族多元化的团队领导。在具体目标 1 中，我们打算领导一个由多学科团队组成的区域卒中协调中心 (RCC)，开展临床试验，测试急性卒中、卒中预防和卒中恢复方面的新型卒中疗法。 UT-休斯顿 RCC 将在大休斯顿地区、圣安东尼奥和新奥尔良的互连站点网络内开展临床试验，涉及成人和儿童患者，并关注少数族裔和女性的招募。在具体目标 2 中，我们将为新试验的设计提供专业知识和领导力，并提出在急性中风、中风预防和中风恢复方面测试新中风疗法的试验。我们还将为从实验室到临床的新型中风疗法的开发以及新型生物标志物的开发和测试提供转化专业知识。在具体目标 3 中，我们将在我们的网络内为具有中风独立研究职业潜力的临床医生科学家建立一个培训计划。