Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy

项目 4：用于粒子闪光放射治疗的笔形束扫描方法的开发和验证

• 批准号: 10573298
• 负责人: Rodney Wiersma
• 金额: $ 32.12万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573298
• 关键词: Algorithms; Animal Experiments; Animals; Biological; Biological Models; Biology; Blood capillaries; Canis familiaris; Clinical; Complex; Computer software; Development; Diffusion; Dose; Dose Rate; Ensure; Future; Gamma Rays; Goals; Investigation; Ions; Linear Energy Transfer; Location; Measurement; Measures; Methodology; Methods; Modeling; Modernization; Monitor; Mus; Nature; Normal tissue morphology; Outcome; Outcome Measure; Outcome Study; Overdose; Oxygen; Patients; Phase I Clinical Trials; Physiologic pulse; Plug-in; Positioning Attribute; Procedures; Protons; Radiation; Radiation therapy; Radiobiology; Reactive Oxygen Species; Research; Resolution; Robotics; Safety; Scanning; Speed; Structure; System; Tail; Techniques; Technology; Testing; Time; Tissues; Translations; Validation; Variant; Vascular blood supply; Vendor; beamline; clinical implementation; design; experience; experimental study; image guided; instrumentation; irradiation; particle; particle beam; preclinical study; prevent; proton therapy; quality assurance; spatial temporal variation; spatiotemporal; success; tool; translational study; transmission process; treatment planning; tumor

Project Summary This project will investigate spatio-temporal delivery of FLASH radiation using pencil beam scanning technology. Modern Pencil Beam Scanning (PBS) technology can deliver spatially non-uniform (Gaussian-like) pencil beam in very high instantaneous dose rate to both shallow and deep-seated tumors; however, the low dose tail of a pencil beam and the relatively slow volume scanning speed for large targets generate a variable dose rate at selected target or normal tissue locations. The impact of this spatial-temporal variation is still unknown for FLASH. Even at the same (averaged) dose rate, degeneracy exists that the FLASH treatment can be delivered by different time-dose sequences. There is a need to study the timing structure of dose delivery in the context of FLASH treatment, as well as measuring and documenting each FLASH treatment so that the outcome can be better understood. Our central hypothesis is that proton PBS can be optimized to deliver FLASH enhanced radiotherapy with existing accelerator technology. The aims of the proposal are: Aim 1 - Investigation of spatio-temporal variations and SOBP versus shoot through PBS beams. Aim 2 - Development of a spatial-temporal biological effective dose model for PBS-based FLASH proton therapy. Aim 3 - Development of fast dose recording instrumentation, image guided positional systems, quality assurance procedures, and end-to-end validation. Success of this project will demonstrate the ability to deliver FLASH to large treatment volumes using proton PBS for the first time. Combined with the ability of proton therapy to accurately deliver dose to deep targets, this will allow translation of PBS FLASH proton therapy to early stage clinical trial studies.

项目概要 该项目将利用笔形束扫描技术研究 FLASH 辐射的时空传递。 现代笔形光束扫描 (PBS) 技术可以提供空间不均匀（类高斯）笔形光束 对浅层和深层肿瘤的瞬时剂量率非常高；然而，低剂量尾部 笔形射束和大型目标相对较慢的体积扫描速度会产生可变剂量率 选定的目标或正常组织位置。这种时空变化的影响对于 闪光。即使在相同（平均）剂量率下，也存在 FLASH 治疗可进行的简并性 通过不同的时间剂量顺序。有必要在以下背景下研究剂量输送的时间结构： FLASH 治疗，以及测量和记录每次 FLASH 治疗，以便可以了解结果 更好理解。我们的中心假设是质子 PBS 可以经过优化以提供 FLASH 增强 使用现有加速器技术进行放射治疗。该提案的目的是： 目标 1 - 研究时空变化和 SOBP 与通过 PBS 光束的射击。 目标 2 - 开发基于 PBS 的 FLASH 的时空生物有效剂量模型 质子治疗。 目标 3 - 开发快速剂量记录仪器、图像引导定位系统、质量 保证程序和端到端验证。 该项目的成功将展示使用质子将 FLASH 传输到大治疗量的能力 PBS 首次。结合质子治疗能够准确地将剂量输送到深层目标的能力， 这将使 PBS FLASH 质子治疗转化为早期临床试验研究。