Quantitative Measurements of Cortical Excitability in Neurodevelopmental Disorder

神经发育障碍中皮质兴奋性的定量测量

• 批准号: 9110300
• 负责人: ANTONIO HARDAN
• 金额: $ 19.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110300
• 关键词: Achievement; Age; Attention deficit hyperactivity disorder; Auditory; Auditory Evoked Potentials; Auditory Threshold; Behavior; Behavioral; Caregivers; Child; Childhood; Classification; Clinical; Data; Development; Diagnosis; Dimensions; Disease; Electroencephalography; Electrophysiology (science); Epilepsy; Equilibrium; Evaluation; Evoked Potentials; Fragile X Syndrome; Frequencies; Goals; Health; High Prevalence; In complete remission; Individual; Investigation; Judgment; Lead; Link; Machine Learning; Measurement; Measures; Modeling; Monitor; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Participant; Patients; Pattern; Performance; Phenotype; Population; Prevalence; Psychopathology; Questionnaires; Research; Rest; Sensory; Sensory Process; Specificity; Stimulus; Strategic Planning; Subgroup; System; Techniques; Variant; Visual; Williams Syndrome; auditory stimulus; autism spectrum disorder; base; endophenotype; indexing; infancy; neuromechanism; programs; response; sensory stimulus; sensory system; somatosensory; therapy design; tool; visual stimulus; visual threshold

 DESCRIPTION (provided by applicant): Neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), are characterized by abnormalities in baseline cortical excitability that are believed to be caused by an abnormal, system-wide balance between excitation and inhibition. Mounting evidence has linked baseline cortical excitability to abnormalities in the sensory systems. as manifested by both over- and hypo- reactivity to sensory stimuli and by the high prevalence of epileptiform EEG activity in the majority of neurodevelopmental disorders including ASD and ADHD. Sensory systems rely on a set of well-characterized network of mechanisms whose functioning directly depends on a precise balancing of excitation and inhibition. The aim of this investigation is to use sensory evoked responses as a means to quantitatively assess baseline cortical excitability in two common neurodevelopmental disorders, ASD and ADHD. These measurements will be made via Steady-State Visual and Auditory Evoked Potentials. Patterns sensory responses measured electrophysiologically will be compared to patterns of behavioral hyper/hyposensitivity measured via a well- characterized parental questionnaire and examiner-administered performance evaluations. These measurements will be obtained from 40 children with ASD, 40 children with ADHD and 40 matched controls. The immediate goal of the project is to determine whether specific patterns of sensory evoked potentials are associated with behavioral indices of disturbed sensory processing. The long-term goal of this proposal is to develop sensitive and objective measures of cortical excitability for use in classifying neurodevelopmental disorders. An ability to detect and quantify underlying alterations in cortical excitability in infancy and ealy childhood would be of significant value in the diagnosis, classification and treatment management of common neurodevelopmental disorders. The present proposal is a fundamental step toward the achievement of this purpose and this approach is consistent with the NIMH Strategic Plan for the development of new ways of classifying psychopathology based on dimensions of observable behavior and neurobiological measures.

 描述（由适用提供）：神经发育障碍，例如自闭症谱系障碍（ASD）和注意力不足多动障碍（ADHD），其特征是基线皮质兴奋性异常，这些兴奋性被认为是由异常的，系统范围的平衡和兴奋和抑制之间引起的。越来越多的证据将基线皮质令人兴奋与感觉系统中的异常联系起来。正如对感觉刺激的过度反应性和性能不反应所表现的，以及在包括ASD和ADHD在内的大多数神经发育障碍中癫痫样脑电图活性的高流行。感觉系统依赖于一组特征良好的机制网络，其功能直接取决于精确的兴奋和抑制平衡。这项研究的目的是使用感官诱发的反应作为定量评估两种常见神经发育疾病的基线皮质刺激性ASD和ADHD的手段。这些测量将通过稳态的视觉和听觉引起的电位进行。在电生理学上测量的感官反应将与通过表征良好的父母问卷调查和审查员管理的绩效评估测量的行为超敏性模式进行比较。这些测量值将从40名ASD，40名ADHD儿童和40个匹配对照的儿童中获得。该项目的直接目标是确定感官诱发电位的特定模式是否与不受欢迎的感觉处理的行为指数有关。该提案的长期目标是开发对神经发育障碍进行分类的皮质兴奋的敏感和客观度量。检测和量化婴儿期皮质兴奋和认真童年的潜在改变的能力在常见神经发育障碍的诊断，分类和治疗管理中具有重要价值。本提案是实现此目的的基本一步，这种方法与基于可观察到的行为和神经生物学测量的维度制定新方法的NIMH战略计划一致。

项目成果

A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.

• DOI: 10.1167/jov.21.4.5
• 发表时间: 2021-04-01
• 期刊: Journal of vision
• 影响因子: 1.8
• 作者: Norcia AM;Lee A;Meredith WJ;Kohler PJ;Pei F;Ghassan SA;Libove RA;Phillips JM;Hardan AY
• 通讯作者: Hardan AY