Developing a Quantitative Assessment Tool for Characterizing Social Domains

开发用于表征社会领域的定量评估工具

• 批准号: 10586621
• 负责人: ANTONIO HARDAN
• 金额: $ 56.64万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586621
• 关键词: 3-Dimensional; Accounting; Adoption; Adult; Age; Assessment tool; Brain; Categories; Child; Clinical; Cognitive; Collection; Companions; Development; Diagnosis; Diagnostic; Dimensions; Disease; Equation; Ethnic Origin; Etiology; Face; Feedback; Focus Groups; Foundations; Future; Goals; Health Care Costs; Impairment; Individual; Information Systems; Information Theory; Interview; Investigation; Language; Measurement; Measures; Methodology; Methods; Modeling; Motivation; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Outcome; Parents; Participant; Patient Outcomes Assessments; Perception; Persons; Population; Process; Protocols documentation; Psychometrics; Public Health; Race; Reporting; Research; Research Domain Criteria; Research Personnel; Risk; Sampling; Social Functioning; Social Processes; Source; Standardization; Structure; Surveys; Testing; Time; Translations; United States National Institutes of Health; Update; Youth; age group; aged; autism spectrum disorder; base; clinical outcome measures; clinical practice; clinically relevant; computerized; design; diagnostic platform; follow-up; functional MRI scan; indexing; individualized medicine; instrument; mental state; neural network; neurobiological mechanism; neuropsychiatry; personalized medicine; recruit; response; sex; social; social communication; social deficits; theories; 3-Dimensional; Accounting; Adoption; Adult; Age; Assessment tool; Brain; Categories; Child; Clinical; Cognitive; Collection; Companions; Development; Diagnosis; Diagnostic; Dimensions; Disease; Equation; Ethnic Origin; Etiology; Face; Feedback; Focus Groups; Foundations; Future; Goals; Health Care Costs; Impairment; Individual; Information Systems; Information Theory; Interview; Investigation; Language; Measurement; Measures; Methodology; Methods; Modeling; Motivation; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Outcome; Parents; Participant; Patient Outcomes Assessments; Perception; Persons; Population; Process; Protocols documentation; Psychometrics; Public Health; Race; Reporting; Research; Research Domain Criteria; Research Personnel; Risk; Sampling; Social Functioning; Social Processes; Source; Standardization; Structure; Surveys; Testing; Time; Translations; United States National Institutes of Health; Update; Youth; age group; aged; autism spectrum disorder; base; clinical outcome measures; clinical practice; clinically relevant; computerized; design; diagnostic platform; follow-up; functional MRI scan; indexing; individualized medicine; instrument; mental state; neural network; neurobiological mechanism; neuropsychiatry; personalized medicine; recruit; response; sex; social; social communication; social deficits; theories

Project Summary/Abstract Social deficits occur across a wide array of neuropsychiatric (NPD) and neurodevelopmental (NDD) disorders and contribute to poor outcomes and sizable public health costs. However, the lack of adequate characterization of mechanisms underpinning social impairments by the current categorical diagnostic systems has significantly stifled the development of etiologically based, individually tailored treatments. A fully dimensional alternative to the categorical frameworks offered by the National Institute of Mental Health’s Research Domain Criteria (RDoC) holds particular promise for a better understanding of mechanisms behind social deficits. More specifically, the RDoC initiative operationalizes an initial set of basic, biologically meaningful components that underpin social functioning, and if disrupted, can impede one’s ability to navigate the complexities of the social world. These processes can therefore be used to better understand social deficits seen across NPD/NDD and inform personalization of treatments. However, we currently lack dedicated measures able to comprehensively capture components of social functioning across clinical, at risk and normative populations which has significantly impeded the translation and adoption of this potentially promising framework. Therefore, the overarching aim of this project is to further expand a recently developed RDoC-based social processes scale: The Stanford Social Dimensions Scale (SSDS). The goal is to refine, factorize, validate and establish regression-based norms of the updated SSDS (SSDS-2). We will also aim to construct a preliminary computerized adaptive testing (CAT) version of the SSDS-2 that will enable individually tailored item selection and administration. These objectives will be achieved by: 1) obtaining feedback on a preliminary item bank from experts and parents of children from normative and clinical groups in order to evaluate the content validity, developmental appropriateness and clinical relevance of the items and to guide the item refinement (Specific Aim 1); 2) utilizing advanced psychometric approaches including exploratory structural equation modeling and item response theory on a large online recruited clinically diverse and normative sample to establish the factor structure (Specific Aim 2); 3) confirming factor structure of the SSDS-2, establishing regression based and standardized change norms and constructing a preliminary CAT version (Specific Aim 3); and further validating the SSDS-2 through an in-person multi-method assessment protocol encompassing interview, observational and experimental methodology with a transdiagnostic sample of youth with a range of social abilities and typically developing youth and their parents. An additional goal is to examine the association between the SSDS-2 subdomains with the neural networks subserving corresponding social processes in a transdiagnostic subsample of youth (Specific Aim 4). This project will lay the foundation for future investigations aimed at: (i) extending the new measure to different age groups (2-5 years and adulthood); (ii) developing a companion clinician-rated structured interview, and (iii) testing its utility as a clinical outcome measure.

项目摘要/摘要 社会缺陷发生在各种神经精神病学（NPD）和神经发育（NDD）疾病中 并促进不良结果和相当大的公共卫生费用。但是，缺乏足够的 通过当前的分类诊断系统的社会障碍的机制表征 已经显着维护了基于病因的，单独量身定制的治疗的发展。一个 国家心理健康研究所提供的分类框架的维度替代方案 研究领域标准（RDOC）具有特别的希望，以更好地理解背后的机制 社会缺陷。更具体地说，RDOC初始运行一组基本，生物学上有意义的一组 支撑社会功能且如果受到干扰的组成部分可能会阻碍人们导航的能力 社会世界的复杂性。因此，这些过程可用于更好地了解社会缺陷 请参阅NPD/NDD，并告知治疗的个性化。但是，我们目前缺乏专用 措施可以全面捕获整个临床，有风险和 正常人口极大地阻碍了这种潜在诺言的翻译和采用 框架。因此，该项目的总体目的是进一步扩展最近开发的基于RDOC 社会过程规模：斯坦福大学社会维度量表（SSD）。目标是完善，分解，验证 并建立更新的SSD（SSDS-2）的基于回归的规范。我们还将旨在构建 SSDS-2的初步计算机化自适应测试（CAT）版本将启用单独量身定制的项目 选择和管理。这些目标将通过：1）获得初步项目的反馈 来自正常和临床组的专家和父母的银行，以评估内容 项目的有效性，发育适当性和临床相关性，并指导项目的完善 （特定目标1）; 2）使用高级心理测量方法，包括探索性结构方程 大型在线招募临床多样化和正常样本的建模和项目响应理论 建立因子结构（特定目标2）； 3）确认SSD-2的因素结构，建立 基于回归和标准化的变更规范并构建初步的CAT版本（特定AIM 3）； 并通过面对面的多方法评估协议进一步验证SSDS-2 访谈，观察和实验方法学，与一系列范围的经诊断样本 社会能力，通常发展青年及其父母。另一个目标是检查协会 在SSDS-2子域之间与神经网络之间的联系 青年的转诊子样本（特定目标4）。该项目将为未来的调查奠定基础 针对：（i）将新的测量值扩展到不同年龄段（2-5岁和成年）； （ii）开发 伴侣临床评级的结构化访谈，以及（iii）测试其效用作为临床结果度量。