Developing a Quantitative Assessment Tool for Characterizing Social Domains

开发用于表征社会领域的定量评估工具

• 批准号: 10586621
• 负责人: ANTONIO HARDAN
• 金额: $ 56.64万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586621
• 关键词: 3-Dimensional; Accounting; Adoption; Adult; Age; Assessment tool; Brain; Categories; Child; Clinical; Cognitive; Collection; Companions; Development; Diagnosis; Diagnostic; Dimensions; Disease; Equation; Ethnic Origin; Etiology; Face; Feedback; Focus Groups; Foundations; Future; Goals; Health Care Costs; Impairment; Individual; Information Systems; Information Theory; Interview; Investigation; Language; Measurement; Measures; Methodology; Methods; Modeling; Motivation; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Outcome; Parents; Participant; Patient Outcomes Assessments; Perception; Persons; Population; Process; Protocols documentation; Psychometrics; Public Health; Race; Reporting; Research; Research Domain Criteria; Research Personnel; Risk; Sampling; Social Functioning; Social Processes; Source; Standardization; Structure; Surveys; Testing; Time; Translations; United States National Institutes of Health; Update; Youth; age group; aged; autism spectrum disorder; base; clinical outcome measures; clinical practice; clinically relevant; computerized; design; diagnostic platform; follow-up; functional MRI scan; indexing; individualized medicine; instrument; mental state; neural network; neurobiological mechanism; neuropsychiatry; personalized medicine; recruit; response; sex; social; social communication; social deficits; theories

Project Summary/Abstract Social deficits occur across a wide array of neuropsychiatric (NPD) and neurodevelopmental (NDD) disorders and contribute to poor outcomes and sizable public health costs. However, the lack of adequate characterization of mechanisms underpinning social impairments by the current categorical diagnostic systems has significantly stifled the development of etiologically based, individually tailored treatments. A fully dimensional alternative to the categorical frameworks offered by the National Institute of Mental Health’s Research Domain Criteria (RDoC) holds particular promise for a better understanding of mechanisms behind social deficits. More specifically, the RDoC initiative operationalizes an initial set of basic, biologically meaningful components that underpin social functioning, and if disrupted, can impede one’s ability to navigate the complexities of the social world. These processes can therefore be used to better understand social deficits seen across NPD/NDD and inform personalization of treatments. However, we currently lack dedicated measures able to comprehensively capture components of social functioning across clinical, at risk and normative populations which has significantly impeded the translation and adoption of this potentially promising framework. Therefore, the overarching aim of this project is to further expand a recently developed RDoC-based social processes scale: The Stanford Social Dimensions Scale (SSDS). The goal is to refine, factorize, validate and establish regression-based norms of the updated SSDS (SSDS-2). We will also aim to construct a preliminary computerized adaptive testing (CAT) version of the SSDS-2 that will enable individually tailored item selection and administration. These objectives will be achieved by: 1) obtaining feedback on a preliminary item bank from experts and parents of children from normative and clinical groups in order to evaluate the content validity, developmental appropriateness and clinical relevance of the items and to guide the item refinement (Specific Aim 1); 2) utilizing advanced psychometric approaches including exploratory structural equation modeling and item response theory on a large online recruited clinically diverse and normative sample to establish the factor structure (Specific Aim 2); 3) confirming factor structure of the SSDS-2, establishing regression based and standardized change norms and constructing a preliminary CAT version (Specific Aim 3); and further validating the SSDS-2 through an in-person multi-method assessment protocol encompassing interview, observational and experimental methodology with a transdiagnostic sample of youth with a range of social abilities and typically developing youth and their parents. An additional goal is to examine the association between the SSDS-2 subdomains with the neural networks subserving corresponding social processes in a transdiagnostic subsample of youth (Specific Aim 4). This project will lay the foundation for future investigations aimed at: (i) extending the new measure to different age groups (2-5 years and adulthood); (ii) developing a companion clinician-rated structured interview, and (iii) testing its utility as a clinical outcome measure.

项目概要/摘要 社交缺陷发生在多种神经精神 (NPD) 和神经发育 (NDD) 疾病中 并导致不良结果和巨大的公共卫生成本。 当前分类诊断系统对社会损害机制的表征 严重抑制了基于病因的个体化治疗的发展。 国家心理健康研究所提供的分类框架的维度替代 研究领域标准 (RDoC) 为更好地理解背后的机制提供了特别的希望 更具体地说，RDoC 倡议实施了一套初步的、具有生物学意义的基本措施。 支撑社会功能的组成部分，如果受到干扰，可能会妨碍一个人驾驭社会的能力 因此，这些过程可以用来更好地理解社会缺陷。 跨 NPD/NDD 并为个性化治疗提供信息然而，我们目前缺乏专门的方法。 能够全面捕捉临床、风险和社会功能组成部分的措施 规范人群严重阻碍了这一潜在前景的翻译和采用 因此，该项目的首要目标是进一步扩展最近开发的基于 RDoC 的 社会过程量表：斯坦福社会维度量表 (SSDS) 的目标是精炼、分解和验证。 并建立更新的 SSDS (SSDS-2) 的基于回归的规范。 SSDS-2 的初步计算机化自适应测试 (CAT) 版本将支持单独定制项目 选择和管理将通过以下方式实现：1) 获得对初步项目的反馈。 来自规范组和临床组的专家和儿童家长的资料库，以评估内容 项目的有效性、发展适当性和临床相关性，并指导项目细化 （具体目标 1）；2）高级利用心理测量方法，包括探索性结构方程 对大量在线招募的临床多样化和规范样本进行建模和项目反应理论 建立因子结构（具体目标2）；3）确认SSDS-2的因子结构，建立 基于回归和标准化的变更规范并构建初步的 CAT 版本（具体目标 3）； 并通过现场多方法评估协议进一步验证 SSDS-2，其中包括 访谈、观察和实验方法，对具有一系列疾病的青少年进行跨诊断样本 社交能力和典型发展的青少年及其父母的另一个目标是检查该协会。 SSDS-2 子域与神经网络之间的关系，支持相应的社会过程 青年跨诊断子样本（具体目标 4）。该项目将为未来的调查奠定基础。 旨在：(i) 将新措施扩展到不同年龄组（2-5 岁和成年）；(ii) 制定一项新措施 陪同临床医生评价的结构化访谈，以及 (iii) 测试其作为临床结果衡量标准的效用。